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Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

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Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi, Sakyo-ku, Kyoto, 606-8501, Japan

    Toru Yagura, Tomoko Motomiya & Michiho Ito

  2. Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji, Hyogo, 670-8524, Japan

    Gisho Honda

  3. Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaoruimachi, Takasaki, Gunma, 370-0033, Japan

    Akira Iida

  4. Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, 1-2 Hachiman-dai, Tsukuba, Ibaraki, 305-0843, Japan

    Fumiyuki Kiuchi

  5. Department of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kawaramachi-hirokoji, Kyoto, 602-0841, Japan

    Harukuni Tokuda & Hoyoku Nishino

Authors
  1. Toru Yagura
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  2. Tomoko Motomiya
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  3. Michiho Ito
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  4. Gisho Honda
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  5. Akira Iida
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  6. Fumiyuki Kiuchi
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  7. Harukuni Tokuda
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  8. Hoyoku Nishino
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Correspondence to Michiho Ito.

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Yagura, T., Motomiya, T., Ito, M. et al. Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum . J Nat Med 62, 174–178 (2008). https://doi.org/10.1007/s11418-007-0223-y

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  • DOI: https://doi.org/10.1007/s11418-007-0223-y

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