Abstract
Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin (1), citflavanone (2), erythrisenegalone (3), lonchocarpol A (4), liquiritigenin (5), and 8-prenyldaidzein (6), were isolated from the extract. Diprenylated flavanone 4 showed a notable antimalarial activity (IC50; 1.6 μg/mL); however 1 and 3 did not show the activity, even though these compounds possessed prenylated substitution.
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Acknowledgments
This work was supported, in part, by funds from the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (grants ID A10124), and a grant of the 21st Century COE program, the Ministry of Education, Culture, Sports, Science and Technology, Japan. Part of the work was also supported by the grant for All Kitasato Project Study (AKPS). The authors thank to Ms. N. Sato for NMR spectroscopy and Ms. A. Nakagawa and C. Sakabe (Kitasato University) for MS measurements.
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Khaomek, P., Ichino, C., Ishiyama, A. et al. In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca . J Nat Med 62, 217–220 (2008). https://doi.org/10.1007/s11418-007-0214-z
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DOI: https://doi.org/10.1007/s11418-007-0214-z