Skip to main content

Studies on the constituents from the fruits of Phaleria macrocarpa

Journal of Natural Medicines volume 62, pages 207–210 (2008)Cite this article

Abstract

From the fruits of Phaleria macrocarpa, icariside C3 (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C3 (1) showed a slow vasorelaxant activity against noradrenaline-induced contraction of isolated rat aorta. The structure of phalerin (2) was revised as 2,4′,6-trihydroxy-4-methoxybenzophenone-2-O-β-d-glucoside.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  1. Harmanto N (1998) Makutodewa Obat Pusaka Para Dewa. Agro Media Pustaka, Jakarta, pp 7–13

    Google Scholar 

  2. Hartati WMS, Mubarika S, Gandjar IG, Hamann MT, Rao KV, Wahyuono S (2005) Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa (Phaleria macrocarpa) leaves. Majalah Farmasi Indones 16:51–57

    CAS  Google Scholar 

  3. Morita H, Eda M, Iizuka T, Hirasawa Y, Sekiguchi M, Yun YS, Itokawa H, Takeya K (2006) Structure of a new cyclic nonapeptide, segetalin F and vasorelaxant activity of segetalins from Vaccaria segetalis. Bioorg Med Chem Lett 17:4458–4461

    Article  Google Scholar 

  4. Morita H, Iizuka T, Choo CY, Chan KL, Takeya K, Kobayashi J (2006) Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa. Bioorg Med Chem Lett 16:4609–4611

    Article  PubMed  CAS  Google Scholar 

  5. Miyase T, Ueno A, Takizawa N, Kobayashi H, Karasawa H (1987) Studies on the glycosides of Epimedium grandiflorum Morr. var. thunbergianum (Miq.) Nakai. I. Chem Pharm Bull 35:1109–1117

    CAS  Google Scholar 

  6. Ferrari J, Terreaux C, Sahpaz SD, Msonthi J, Wolfender JL, Hostettmann K (2000) Benzophenone glycosides from Gnidia involucrata. Phytochemistry 54:883–889

    Article  PubMed  CAS  Google Scholar 

  7. Fujita M, Inoue T (1982) Studies on the constituents of Iris flo-. rentina L. II. C-glucosides of xanthones and flavones from the leaves. Chem Pharm Bull 30:2342–2348

    CAS  Google Scholar 

  8. Nagai M, Noguchi M, Iizuka T, Otani K, Kamata K (1996) Vasodilator effects of des(α-carboxy-3,4-dihydroxyphenethyl)lithospermic acid (8-epiblechnic acid), a derivative of lithospermic acids in salviae miltiorrhizae radix. Biol Pharm Bull 19:228–233

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant by the Open Research Center Project. We gratefully acknowledge the financial support provided by Assessment Service Unit, Faculty of Pharmacy, Airlangga University.

Author information

Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, 142-8501, Japan

    Shiori Oshimi, Kazumasa Zaima, Yosuke Matsuno, Yusuke Hirasawa, Toru Iizuka & Hiroshi Morita

  2. Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, Indonesia

    Herra Studiawan, Gunawan Indrayanto & Noor Cholies Zaini

Authors
  1. Shiori Oshimi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazumasa Zaima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yosuke Matsuno
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yusuke Hirasawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Toru Iizuka
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Herra Studiawan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gunawan Indrayanto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Noor Cholies Zaini
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroshi Morita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroshi Morita.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Oshimi, S., Zaima, K., Matsuno, Y. et al. Studies on the constituents from the fruits of Phaleria macrocarpa . J Nat Med 62, 207–210 (2008). https://doi.org/10.1007/s11418-007-0209-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11418-007-0209-9

Keywords

  • Phaleria macrocarpa
  • Vasorelaxant activity
  • Icariside C3
  • Phalerin
  • Mangiferin