From the fruits of Phaleria macrocarpa, icariside C3 (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C3 (1) showed a slow vasorelaxant activity against noradrenaline-induced contraction of isolated rat aorta. The structure of phalerin (2) was revised as 2,4′,6-trihydroxy-4-methoxybenzophenone-2-O-β-d-glucoside.
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This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant by the Open Research Center Project. We gratefully acknowledge the financial support provided by Assessment Service Unit, Faculty of Pharmacy, Airlangga University.
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Oshimi, S., Zaima, K., Matsuno, Y. et al. Studies on the constituents from the fruits of Phaleria macrocarpa . J Nat Med 62, 207–210 (2008). https://doi.org/10.1007/s11418-007-0209-9
- Phaleria macrocarpa
- Vasorelaxant activity
- Icariside C3