The present study was carried out to elucidate the potential of aqueous extract of Muntingia calabura leaves aqueous extract (MCAE) as antinociceptive, anti-inflammatory and antipyretic agents using the formalin-, carrageenan-induced paw edema- and brewer’s yeast-induced pyrexia tests in rats. The extract was prepared by soaking the dried powdered leaves of M. calabura in distilled water (dH2O) overnight. The supernatant obtained, considered as a stock solution (100% concentration/strength), was then diluted to concentrations of 10% and 50% and used together in all experimental models. The MCAE, at concentrations of 10%, 50% and 100%, were found to show significant antinociceptive, anti-inflammatory and antipyretic activities in all tests. However, all of the activities occurred in a concentration-independent manner. The 50% and 100% concentrations of MCAE produced insignificant antinociceptive and antipyretic activities, respectively. Although the 100% concentration of MCAE produced significant (P<0.05) anti-inflammatory activity, the activity was lower than that of the 10% and 50% concentrations of MCAE. Based on the results, we conclude that the M. calabura leaves possessed antinociceptive, anti-inflammatory and antipyretic activities and, thus, justifies the Peruvian folklore claims of its medicinal values.
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This study was supported by a research grant of the Universiti Industri Selangor, Malaysia (project code number: 03013; project vote number: 3090103013). The authors would like to thank the Universiti Putra Malaysia for the use of their facilities.
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Zakaria, Z.A., Nor Hazalin, N.A.M., Zaid, S.N.H.M. et al. Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models. J Nat Med 61, 443–448 (2007). https://doi.org/10.1007/s11418-007-0167-2
- Muntingia calabura
- Aqueous extract