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New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro

Abstract

Two new prenylated flavones, artocarpones A and B (1 and 2), and seven known isoprenylated flavonoids, artonin A (3), cycloheterophyllin (4), artoindonesianin E (5), artoindonesianin R (6), heterophyllin (7), heteroflavanone C (8), and artoindonesianin A-2 (9), have been isolated from the stem bark of Artocarpus champeden. Their structures were determined by spectroscopic analysis. Among the compounds isolated, 8 had the most potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with an IC50 value of 1 nmol L−1.

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Acknowledgments

Parts of this work were supported by Grant for Hibah Pascasarjana (no. 748/JO3.2/PG/2005) from The Ministry of Education, Indonesia, and by Grant-in-Aid for International Scientific Research (no. 16406002) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Correspondence to Shigetoshi Kadota.

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Widyawaruyanti, A., Subehan, Kalauni, S.K. et al. New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro. J Nat Med 61, 410–413 (2007). https://doi.org/10.1007/s11418-007-0153-8

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  • DOI: https://doi.org/10.1007/s11418-007-0153-8

Keywords

  • Artocarpus champeden
  • Moraceae
  • Prenylated flavones
  • Antimalarial activity
  • Plasmodium falciparum