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Journal of Natural Medicines

, Volume 61, Issue 3, pp 269–279 | Cite as

The chemical constituents of fresh Gentian Root

  • Hidehiro Ando
  • Yasuaki Hirai
  • Mikio Fujii
  • Yumiko Hori
  • Motonori Fukumura
  • Yujiro Niiho
  • Yoshijiro Nakajima
  • Toshiro Shibata
  • Kazuo Toriizuka
  • Yoshiteru Ida
Original Paper

Abstract

We isolated and characterized 23 compounds, including a new iridoid named gentiolutelin and its dimethyl acetal, and a new lignan named gentioluteol from fresh roots (including small amounts of rhizome) of Gentiana lutea cultivated in Japan (Hokkaido). The structures of gentiolutelin and gentioluteol were determined as (1S,2R,3S,5R)-3-hydroxy-2-methyl-5-(2-oxoethyl)-cyclopentanecarboxylic acid methyl ester and (7R,8S,8′S)-4,4′,8,9-tetrahydroxy-3,3′,5-trimethoxy-7,9′-epoxylignan, respectively, on the basis of chemical and spectroscopic evidence. It was noteworthy that gentiopicroside, known to be a major secoiridoid glycoside in Gentian root, was not detected from the fresh roots of 3-year-old G. lutea.

Keywords

Gentiolutelin Gentioluteol Iridoid Lignan Gentiana lutea Gentian root 

Notes

Acknowledgment

We thank Ms. Kimiko Shiohara for measurement of MS spectra and Dr. Masayuki Watanabe for measurement of CD spectra at JASCO corporation.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2007

Authors and Affiliations

  • Hidehiro Ando
    • 1
  • Yasuaki Hirai
    • 1
  • Mikio Fujii
    • 1
  • Yumiko Hori
    • 1
  • Motonori Fukumura
    • 1
  • Yujiro Niiho
    • 2
  • Yoshijiro Nakajima
    • 2
  • Toshiro Shibata
    • 3
  • Kazuo Toriizuka
    • 1
  • Yoshiteru Ida
    • 1
    • 4
  1. 1.School of Pharmaceutical SciencesShowa UniversityTokyoJapan
  2. 2.Tsukuba Research InstituteOhta’s Isan Co. Ltd.IbarakiJapan
  3. 3.Hokkaido Division, Research Center for Medicinal Plant ResourcesNational Institute of Biomedical InnovationHokkaidoJapan
  4. 4.Yokohama College of PharmacyYokohamaJapan

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