Abstract
The marine-derived cembranoid sarcophine (1) and its sulfur-containing semisynthetic derivatives (2–6) were evaluated for anticancer potential using cell cycle progression markers. No effect on MCF-7 cell viability or apoptosis was seen with these derivatives at concentrations of up to 100 μM after 72 h of incubation. At 100 μM, sarcophine and its derivatives 2–5 arrested the MCF-7 cells in G0/G1 phase, with concomitant decrease in the cell populations at S and G2+M phases. MDA-MB-231 cells were not responsive to any of the derivatives. Our preliminary results suggest that the sulfur-containing derivatives of sarcophine, especially 2 and 3, show potent and cell-specific antiproliferative activity.
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Acknowledgments
The authors are thankful to Dr. Khaled Y. Orabi, Kuwait University, Kuwait, for help in the procurement of the marine compounds. Dr. R. A. Hill, Dr. A. M. Crider, and Dr. M. E. Arant are acknowledged for their valuable discussions. This publication was made possible by NIH grant no. P20 PR16456 from the BRIN Program of the National Center for Research Resources. Philip Morris USA Inc., Richmond, VA, is also acknowledged for financial support.
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Arif, J.M., Sawant, S.S., El Sayed, K.A. et al. Antiproliferative potential of sarcophine and its semisynthetic sulfur-containing derivatives against human mammary carcinoma cell lines. J Nat Med 61, 154–158 (2007). https://doi.org/10.1007/s11418-006-0113-8
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DOI: https://doi.org/10.1007/s11418-006-0113-8