Journal of Natural Medicines

, Volume 60, Issue 3, pp 236–239 | Cite as

Two fucoidans in the holdfast of cultivated Laminaria japonica

  • Tomohiro Ozawa
  • Jynji Yamamoto
  • Takashi Yamagishi
  • Noriyuki Yamazaki
  • Makoto Nishizawa
Original Paper


Two fucoidans have been isolated from the holdfast of cultivated Laminaira japonica. One (L-fucoidan) is rich in fucose and sulfate; the other (GA-fucoidan) is rich in uronate. L-fucoidan was found in the fronds of L. japonica (cultivated and wild), L. angustata, and Kjellmaniella crassifolia whereas GA-fucoidan was not detected in these fronds and may be a fucoidan specific to the holdfast. These two fucoidans were proved to have anti-tumor activity against Adenocarcinoma 755-transplanted mice by i.p. and p.o. administration.


Laminaira japonica Cultivated Holdfast Fucoidan Anti-tumor activity 


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2006

Authors and Affiliations

  • Tomohiro Ozawa
    • 1
  • Jynji Yamamoto
    • 2
  • Takashi Yamagishi
    • 3
  • Noriyuki Yamazaki
    • 4
  • Makoto Nishizawa
    • 5
  1. 1.Kyosei Pharmaceutical Co. Ltd.EniwaJapan
  2. 2.Sakai Chemical Industries Co. Ltd.KawachinaganoJapan
  3. 3.Kitami Institute of TechnologyKitamiJapan
  4. 4.New Drug Development Research Center Inc.EniwaJapan
  5. 5.Tokyo University of AgricultureAbashiriJapan

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