Two fucoidans in the holdfast of cultivated Laminaria japonica
- 223 Downloads
Two fucoidans have been isolated from the holdfast of cultivated Laminaira japonica. One (L-fucoidan) is rich in fucose and sulfate; the other (GA-fucoidan) is rich in uronate. L-fucoidan was found in the fronds of L. japonica (cultivated and wild), L. angustata, and Kjellmaniella crassifolia whereas GA-fucoidan was not detected in these fronds and may be a fucoidan specific to the holdfast. These two fucoidans were proved to have anti-tumor activity against Adenocarcinoma 755-transplanted mice by i.p. and p.o. administration.
KeywordsLaminaira japonica Cultivated Holdfast Fucoidan Anti-tumor activity
- 1.Chuyaku Daijiten (1985) Shanhai Kagaku-gijutsu shuppansha and Shogakkan, pp 218–219Google Scholar
- 6.Usui T, Asari K, Mizuno T (1980) Isolation of highly purified “fucoidan” from Eisenia bicyclis and its anticoagulant and antitumor activities. Agric Biol Chem 44:1965–1966Google Scholar
- 12.Kitamura K, Matsuo M, Yasui T (1991) Fucoidan from brown seaweed Laminaria angustata var. longissima. Agric Biol Chem 55:615–616Google Scholar
- 13.Takahashi M (1983) Studies on the mechanism of host-mediated antitumor action of crude fucoidan from a brown alga Eisenia bicylis (in Japanese). J Jpn Soc Reticuloendothel Sys 22:269–283Google Scholar