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Journal of Natural Medicines

, Volume 60, Issue 3, pp 231–235 | Cite as

Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells

  • Shunji Aoki
  • Seok-hwan Cho
  • Atsushi Hiramatsu
  • Naoyuki Kotoku
  • Motomasa Kobayashi
Original Paper

Abstract

Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a bastarane-type skeleton was important for the selective activity of these bastadins against endothelial cells. A conformational analysis of the bastadins was also carried out by molecular mechanics calculation.

Keywords

Anti-proliferation Bastadins Endothelial cell Marine sponge 

Notes

Acknowledgements

The authors are grateful to the Takeda Science Foundation and the Ministry of Education, Culture, Sports, Science, and Technology of Japan for financial support.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2006

Authors and Affiliations

  • Shunji Aoki
    • 1
  • Seok-hwan Cho
    • 1
  • Atsushi Hiramatsu
    • 1
  • Naoyuki Kotoku
    • 1
  • Motomasa Kobayashi
    • 1
  1. 1.Graduate School of Pharmaceutical SciencesOsaka UniversityOsakaJapan

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