Journal of Natural Medicines

, Volume 60, Issue 3, pp 231–235 | Cite as

Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells

  • Shunji Aoki
  • Seok-hwan Cho
  • Atsushi Hiramatsu
  • Naoyuki Kotoku
  • Motomasa Kobayashi
Original Paper


Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a bastarane-type skeleton was important for the selective activity of these bastadins against endothelial cells. A conformational analysis of the bastadins was also carried out by molecular mechanics calculation.


Anti-proliferation Bastadins Endothelial cell Marine sponge 



The authors are grateful to the Takeda Science Foundation and the Ministry of Education, Culture, Sports, Science, and Technology of Japan for financial support.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2006

Authors and Affiliations

  • Shunji Aoki
    • 1
  • Seok-hwan Cho
    • 1
  • Atsushi Hiramatsu
    • 1
  • Naoyuki Kotoku
    • 1
  • Motomasa Kobayashi
    • 1
  1. 1.Graduate School of Pharmaceutical SciencesOsaka UniversityOsakaJapan

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