New penicillide derivatives isolated from Penicillium simplicissimum
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Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.
KeywordsPenicillium simplicissimum Penicillide Secopenicillide A Secopenicillide B Purpactin A Antifungal activity
We are grateful to Dr. H. Kasai and Miss N. Kobayashi of Hoshi University for NMR and MS spectral measurements. This study was supported in part by Hoshi University Science/Technology Frontier Research Base from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by a cooperative research program of the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University (2004-22).
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