Journal of Natural Medicines

, Volume 60, Issue 3, pp 185–190 | Cite as

New penicillide derivatives isolated from Penicillium simplicissimum

  • Shin-ichirou Komai
  • Tomoo Hosoe
  • Takeshi Itabashi
  • Koohei Nozawa
  • Takashi Yaguchi
  • Kazutaka Fukushima
  • Ken-ichi Kawai
Original Paper

Abstract

Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.

Keywords

Penicillium simplicissimum Penicillide Secopenicillide A Secopenicillide B Purpactin A Antifungal activity 

Notes

Acknowledgements

We are grateful to Dr. H. Kasai and Miss N. Kobayashi of Hoshi University for NMR and MS spectral measurements. This study was supported in part by Hoshi University Science/Technology Frontier Research Base from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by a cooperative research program of the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University (2004-22).

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2006

Authors and Affiliations

  • Shin-ichirou Komai
    • 1
  • Tomoo Hosoe
    • 1
  • Takeshi Itabashi
    • 1
  • Koohei Nozawa
    • 2
  • Takashi Yaguchi
    • 3
  • Kazutaka Fukushima
    • 3
  • Ken-ichi Kawai
    • 1
  1. 1.Faculty of Pharmaceutical SciencesHoshi UniversityTokyo 142-8501Japan
  2. 2.School of Pharmaceutical SciencesOhu UniversityFukushima 963-8611Japan
  3. 3.Research Center for Pathogenic Fungi and Microbial ToxicosesChiba University Chiba 260-8673Japan

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