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Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis


Ent-kaurane-type diterpenpoids 111, isolated from the dried leaves of the endemic Vietnamese medicinal plant Croton tonkinensis Gagnep. (Euphorbiaceae), were evaluated for inhibitory activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains. The most active diterpenoids, 2, 3, and 8, exhibited minimum inhibitory concentrations (MICs) of 32, 500, and 125 μg/ml, respectively, against MRSA strains.

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This work was supported by a Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS). P.M.G. is grateful to acknowledge the International Foundation for Science (Stockholm, Sweden) for the financial support. We thank Professor Sugiyama M (Graduate School of Biomedical Sciences, Hiroshima University) for the generous gift of methicillin-resistant Staphylococcus aureus B-26 strain.

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Correspondence to Hideaki Otsuka.

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Giang, P.M., Son, P.T., Matsunami, K. et al. Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis. J Nat Med 60, 93–95 (2006).

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  • Ent-kaurane
  • Diterpenoid
  • Croton tonkinensis
  • Euphorbiaceae
  • Staphylococcus aureus
  • MRSA