Healthcare Cost Reductions Associated with the Use of LAI Formulations of Antipsychotic Medications Versus Oral Among Patients with Schizophrenia

  • Jay LinEmail author
  • Bruce Wong
  • Steve Offord
  • Dario Mirski


Real-world medication adherence and healthcare costs of patients with schizophrenia initiating long-acting injectable (LAI) vs. oral antipsychotics were compared. Patients with schizophrenia initiating LAI or oral antipsychotics (index event) were identified from MarketScan Commercial and Medicare claims databases and their medication possession ratios (MPR), pre- and post-index costs for inpatient/outpatient care were compared. Of 3,004 patients, 394 initiated LAI antipsychotics and 2,610 oral antipsychotics. Post-index, the mean MPR was greater for the LAI cohort (0.67 ± 0.34 vs. 0.56 ± 0.35; p < 0.001). Schizophrenia-related hospital costs for LAI users were reduced during the follow-up period in comparison to the pre-index period, but were increased for patients using oral antipsychotics (-$5,981 ± $16,554 vs. 758 ± 14,328, p < 0.001). The change in costs of outpatient care also favored LAI medications ($134 ± 8,280 vs. 658 ± 3,260, p = 0.023). Drug costs of LAI antipsychotics were higher ($4,132 ± 4,533 vs. 2,562 ± 2,714, p < 0.001). Schizophrenia patients initiating LAI antipsychotics incur less healthcare costs in comparison to patients initiating oral antipsychotics.


Schizophrenia Antipsychotic Medication Medication Possession Ratio Antipsychotic Therapy Prescription Drug Coverage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of Interest

Declaration of funding—this research was supported by Otsuka America Pharmaceutical, Inc. and H. Lundbeck A/S. Declaration of financial/other relationships—Jay Lin is an employee of Novosys Health, which has received research funds from Otsuka America Pharmaceutical, Inc. in connection with conducting this study and development of this manuscript. Bruce Wong is a paid consultant for Otsuka America Pharmaceutical, Inc. in connection with conducting this study and development of this manuscript. Steve Offord and Dario Mirski are employees of Otsuka America Pharmaceutical, Inc.


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Copyright information

© National Council for Community Behavioral Healthcare 2013

Authors and Affiliations

  • Jay Lin
    • 1
    Email author
  • Bruce Wong
    • 2
  • Steve Offord
    • 3
    • 4
  • Dario Mirski
    • 3
    • 4
  1. 1.Novosys HealthFlemingtonUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA
  3. 3.Otsuka America Pharmaceutical, IncPrincetonUSA
  4. 4.Otsuka America Pharmaceutical, IncPrincetonUSA

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