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Kolonpolypen – Nomenklatur, Histologie und Molekularpathologie

Colon polyps—nomenclature, histology, and molecular pathology

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Zusammenfassung

Polypen sind makroskopisch sichtbare Ausstülpungen der Mukosa in Hohlorganen. Im Kolon dominieren epitheliale Neubildungen, die sich von der Mukosa ableiten. Diese lassen sich nach ihrer Morphologie in klassische und serratierte Adenome klassifizieren und zeigen unterschiedliche Grade an Epitheldysplasie. Die histologischen Subtypen weisen verschiedene molekulare Alterationen auf und können so unterschiedlichen Karzinogenesewegen zugeordnet werden. Davon abzugrenzen sind hamartomatöse Polypen der Kolonschleimhaut, die sporadisch oder im Rahmen von erblichen Syndromen auftreten können.

Abstract

Polyps are macroscopically visible protrusions of the mucosa in hollow organs. In the colon, epithelial neoplasms deriving from the mucosa dominate. These can be classified based on their morphology into classic and serrated adenomas and show different degrees of epithelial dysplasia. The histological subtypes show various molecular alterations and can be assigned to different pathways of carcinogenesis. These must be separated from hamartomatous polyps of the colon mucosa, which can occur sporadically or as part of hereditary syndromes.

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Authors and Affiliations

  1. Pathologisches Institut, Medizinische Fakultät, Ludwig-Maximilians-Universität München, Thalkirchner Straße 36, 80337, München, Deutschland

    Jens Neumann

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  1. Jens Neumann
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Correspondence to Jens Neumann.

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Interessenkonflikt

J. Neumann hat für Agilent, Astrellas, BMS, Falk, MSD, Pierre Fabre, Pfizer und Roche Beratungstätigkeiten ausgeübt und Honorare für Vorträge erhalten.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Irene Esposito, Düsseldorf

Andrea Tannapfel, Bochum

Eva Wardelmann, Münster

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Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral.

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Neumann, J. Kolonpolypen – Nomenklatur, Histologie und Molekularpathologie. Gastroenterologie (2024). https://doi.org/10.1007/s11377-024-00776-w

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  • DOI: https://doi.org/10.1007/s11377-024-00776-w

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