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Gastroösophageale Refluxerkrankung und geschlechtsspezifische Unterschiede

Gastroesophageal reflux disease and gender-specific differences

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Zusammenfassung

Die gastroösophageale Refluxerkrankung (GERD) stellt eines der häufigsten gastroenterologischen Krankheitsbilder dar und zeigt einen deutlichen Anstieg der Prävalenz in den letzten Jahren. In der Krankheitsausprägung und -entstehung existieren geschlechtsspezifische Unterschiede, die differenziert betrachtet werden sollten. Männer haben eine stärkere Ausbildung der GERD in Hinblick auf den Grad der Entzündung und den Säurereflux. Wahrscheinlich ist aus diesem Grund das Risiko für die Entwicklung eines Barrett-Ösophagus bei Männern etwa 2‑ bis  3-fach und für ein ösophageales Adenokarzinom sogar 3‑ bis  6-mal höher als bei Frauen. Dies unterstreicht die Notwendigkeit, geschlechtsspezifische Unterschiede der GERD besser zu verstehen, um Diagnostik, Therapie und Prävention zu optimieren.

Abstract

Gastroesophageal reflux disease (GERD) represents one of the most common gastrointestinal diseases and has shown a significant increase in prevalence in recent years. There are gender-specific differences in GERD both for disease characteristics and development of the disease. Men suffer from more severe reflux with a higher grade of inflammation and acid reflux. Most probably, this seems to be the underlying reason why men have a higher risk for the development of disease-associated complications like Barrett’s esophagus (approximately 2- to 3‑fold) and esophageal adenocarcinoma (3 to 6 times higher). This underlines the importance of better understanding the gender-specific differences of GERD in order to optimize patient care including prevention, diagnosis and treatment.

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  1. Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland

    M. Selgrad,  M. Müller-Schilling &  A. Kandulski

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  1. M. Selgrad
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M. Müller-Schilling, Regensburg

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Selgrad, M., Müller-Schilling, M. & Kandulski, A. Gastroösophageale Refluxerkrankung und geschlechtsspezifische Unterschiede. Gastroenterologe 14, 96–101 (2019). https://doi.org/10.1007/s11377-019-0322-9

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