Skip to main content
Log in

Blähungen und Reizdarmsyndrom (RDS)

Bloating and irritable bowel syndrome (IBS)

  • Schwerpunkt
  • Published:
Der Gastroenterologe Aims and scope

Zusammenfassung

Patienten mit funktionellen Verdauungsbeschwerden wie dem Reizdarmsyndrom (RDS) beklagen häufig Blähungen und ein aufgetriebenes Abdomen. Das subjektive Gefühl eines aufgeblähten Bauches, welches nicht zwangsläufig mit einer objektiven Zunahme des Abdomenumfangs einhergehen muss, wird als Blähungen oder Meteorismus bezeichnet. Bei Patienten mit RDS konnten Störungen der intestinalen Gasdynamik bei gleichzeitiger viszeraler Hypersensibilität als eine wesentliche Ursache für Blähungen nachgewiesen werden. Eine weitere Ursache könnte die Abdomenumfangszunahme auch ohne Erhöhung des Darmvolumens sein. Dies kann durch eine abnorme Relaxation der anterioren Bauchmuskulatur oder eine Fehlregulation des Tonus der Zwerchfellmuskulatur verursacht werden. Die Vielschichtigkeit der Problematik bedingt individuelle Strategien und komplexe Therapieansätze mit dem Ziel einer Normalisierung der Darmtätigkeit und -empfindung.

Abstract

Complaints such as abdominal bloating and distension are frequent in patients with functional intestinal diseases, including irritable bowel syndrome (IBS). Bloating or meteorism is defined as the subjective perception of abdominal distension and does not necessarily accompany objective abdominal distension. Disturbances of intestinal gas dynamics with hypersensitivity has been detected as a significant cause of bloating in IBS patients. Abdominal distension with no increase in bowel contents (e. g., by abnormal relaxation of the anterior abdominal muscles or phrenic dysregulation) is another important mechanism of bloating. The multilayered problem of abdominal bloating and distension, especially in IBS patients, requires individual strategies and complex therapies with the goal of normalizing intestinal activity and patient perception.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Lembo T, Naliboff B, Munakata J et al. (1999) Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome. Am J Gastroenterol 94: 1320–1326

    Article  PubMed  CAS  Google Scholar 

  2. Chang L, Lee OY, Naliboff B et al. (2001) Sensation of bloating and visible abdominal distension in patients with irritable bowel syndrome. Am J Gastroenterol 96: 3341–3347

    Article  PubMed  CAS  Google Scholar 

  3. Hasler WL (2007) Irritable bowel syndrome and bloating. Best Pract Res Clin Gastroenterol 21: 689–707

    Article  PubMed  Google Scholar 

  4. Houghton LA, Whorwell PJ (2005) Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders. Neurogastroenterol Motil 17: 500–511

    Article  PubMed  CAS  Google Scholar 

  5. Talley NJ, Quan C, Jones MP, Horowitz M (2004) Association of upper and lower gastrointestinal tract symptoms with body mass index in an australian cohort. Neurogastroenterol Motil 16: 413–419

    Article  PubMed  CAS  Google Scholar 

  6. Serra J, Azpiroz F, Malagelada JR (2001) Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome. Gut 48: 14–19

    Article  PubMed  CAS  Google Scholar 

  7. Salvioli B, Serra J, Azpiroz F et al. (2005) Origin of gas retention and symptoms in patients with bloating. Gastroenterology 128: 574–579

    Article  PubMed  Google Scholar 

  8. Pérez FAA, Azpíroz F, Quiroga S, Malagelada JR (2007) Where does bloating come from: abdominal walls or content? Gastroenterology 132: A 460

    Google Scholar 

  9. Harder H, Serra J, Azpiroz F et al. (2003) Intestinal gas distribution determines abdominal symptoms. Gut 52: 1708–1713

    Article  PubMed  CAS  Google Scholar 

  10. Galati JS, McKee DP, Quigley EM (1995) Response to intraluminal gas in irritable bowel syndrome. Motility versus perception. Dig Dis Sci 40: 1381–1387

    Article  PubMed  CAS  Google Scholar 

  11. Harder H, Hernando-Harder AC, Franke A et al. (2006) Role of the jejunum versus ileum on intestinal gas dynamics during a balanced meal in healthy subjects. Dig Dis Sci 51: 996–1002

    Article  PubMed  Google Scholar 

  12. Houghton LA, Lea R, Agrawal A et al. (2006) Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit. Gastroenterology 131: 1003–1010

    Article  PubMed  Google Scholar 

  13. Tremolaterra F, Villoria A, Azpiroz F et al. (2006) Impaired viscerosomatic reflexes and abdominal-wall dystony associated with bloating. Gastroenterology 130: 1062–1068

    Article  PubMed  Google Scholar 

  14. Palsson OS, Drossman DA (2005) Psychiatric and psychological dysfunction in irritable bowel syndrome and the role of psychological treatments. Gastroenterol Clin North Am 34: 281–303

    Article  PubMed  Google Scholar 

  15. Van der Veek PP, Steenvoorden M, Steens J et al. (2007) Recto-colonic reflex is impaired in patients with irritable bowel syndrome. Neurogastroenterol Motil 19: 653–659

    Article  Google Scholar 

  16. Trowell HC, Burkitt DP (1987) The development of the concept of dietary fibre. Mol Aspects Med 9: 7–15

    Article  PubMed  CAS  Google Scholar 

  17. Hills JM, Aaronson PI (1991) The mechanism of action of peppermint oil on gastrointestinal smooth muscle. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig. Gastroenterology 101: 55–65

    PubMed  CAS  Google Scholar 

  18. Krammer HJ, Schlieger F, Harder H et al. (2005) Probiotics as therapeutic agents in irritable bowel syndrome. Z Gastroenterol 43: 467–471

    Article  PubMed  Google Scholar 

  19. Fumi AL, Trexler K (2008) Rifaximin treatment for symptoms of irritable bowel syndrome. Ann Pharmacother 42: 408–412

    Article  PubMed  CAS  Google Scholar 

  20. Galinsky D, Mimidis K, Zicherman Y, Oreopoulos D (2004) The use of an electromechanical device for treatment of constipation in the elderly. J Am Geriatr Soc 52: 475–476

    Article  PubMed  Google Scholar 

  21. Meyers NL, Hickling RI (2008) Pharmacology and metabolism of renzapride: a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs RD 9: 37–63

    Article  CAS  Google Scholar 

  22. Camilleri M, Vazquez-Roque MI, Burton D et al. (2007) Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans. Neurogastroenterol Motil 19: 30–38

    Article  PubMed  CAS  Google Scholar 

  23. Andresen V, Camilleri M, Busciglio IA et al. (2007) Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology 133: 761–768

    Article  PubMed  CAS  Google Scholar 

  24. Sanger GJ, Alpers DH (2008) Development of drugs for gastrointestinal motor disorders: translating science to clinical need. Neurogastroenterol Motil 20: 177–184

    Article  PubMed  CAS  Google Scholar 

  25. Morgan V, Pickens D, Gautam S et al. (2005) Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 54: 601–607

    Article  PubMed  CAS  Google Scholar 

  26. Delvaux M, Beck A, Jacob J et al. (2004) Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 20: 237–246

    Article  PubMed  CAS  Google Scholar 

  27. Castiglione F, Daniele B, Mazzacca G (1991) Therapeutic strategy for the irritable bowel syndrome. Ital J Gastroenterol 23: 53–55

    PubMed  CAS  Google Scholar 

  28. Lembo AJ, Olden KW, Ameen VZ et al. (2004) Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials. Clin Gastroenterol Hepatol 2: 675–682

    Article  PubMed  CAS  Google Scholar 

  29. Camilleri M, Kim DY, McKinzie S et al. (2003) A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 1: 111–121

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenskonflikt

Der korrespondierende Autor gibt an, dass kein Interessenskonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H. Harder.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hernando-Harder, A., Singer, M. & Harder, H. Blähungen und Reizdarmsyndrom (RDS). Gastroenterologe 3, 480–487 (2008). https://doi.org/10.1007/s11377-008-0212-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11377-008-0212-z

Schlüsselwörter

Keywords

Navigation