Zusammenfassung
Eine endoskopische Untersuchung muss effektiv, sicher und für den Patienten so angenehm wie möglich sein. Eine adäquate Sedierung des Patienten während der Untersuchung leistet hierzu einen wesentlichen Beitrag. Adipöse Patienten weisen ein erhöhtes Risiko während der Sedierung auf, wenn gleichzeitig kardiopulmonale Begleiterkrankungen vorliegen. Es ist dementsprechend auf ein adäquates Monitoring zu achten. Insbesondere im Hinblick auf eventuelle Schwierigkeiten bei einer Intubation muss in ausgewählten Fällen ein weiterer, intensivmedizinisch oder anästhesiologisch erfahrener Arzt hinzugezogen werden. Dosisanpassungen bei Sedativa und Opiaten sind erforderlich. Propofol weist hinsichtlich seiner pharmakologischen Eigenschaften Vorteile für die Sedierung von adipösen Patienten auf.
Abstract
An endoscopic examination must be effective, safe, and as comfortable as possible for the patient. Adequate sedation of the patient during the examination makes a considerable contribution toward achieving this goal. Obese patients are at increased risk during sedation in the presence of concomitant cardiopulmonary diseases. Attention should therefore be given to ensuring adequate monitoring. Particularly with regard to potential difficulties in intubation, another physician experienced in intensive medicine or anesthesiology should be consulted in selected cases. Sedative and opiate doses have to be adjusted accordingly. With respect to its pharmacological properties, propofol exhibits advantages in the sedation of obese patients.
Literatur
Cheymol G (2000) Effects of obesity on pharmacokinetics implications for drug therapy. Clin Pharmacokinet 39(3): 215–231
Riphaus A, Rabofski M, Wehrmann T (2007) Zeitschrift für Gastroenterologie 08 (Endoskopie) P131
Delius von S, Hollweck R, Schmid RM, Frimberger E (2007) Midazolam-pain, but one cannot remember it: a survey among Southern German endoscopists. Eur J Gastroenterol Hepatol 19(6): 465–470
Casati A, Putzu M (2005) Anesthesia in the obese patient: pharmacokinetic considerations. J Clin Anesth 17(2): 134–145
Greenblatt DJ, Abernethy DR, Locniskar A et al. (1984) Effect of age, gender and obesity on midazolam kinetics. Anesthesiolo 61(1): 27–35
Yi SY, Shin JE (2005) Midazolam for patients undergoing upper gastrointestinal endoscopy: a prospective, single-blind and randomized study to determine the appropriate amount and time of initiation of endoscopy. J Gastroenterol Hepatol 20(12): 1873–1879
Roche Fachinformation zu Dormicum® Injektionslösung, Stand Juni 2006
Bell GD, Morden A, Coady T et al. (1988) A comparison of diazepam and midazolam as endoscopy premedication assessing changes in ventilation and oxygen saturation. Br J Clin Pharmacol 26(5): 595–600
von Delius S, Hollweck R, Schmid RM, Frimberger E (2007) Midazolam-pain, but one cannot remember it: a survey among Southern German endoscopists. Eur J Gastroenterol Hepatol 19(6): 465–470
Sprigge JS, East DS, Fox GS et al. (1982) Meperidine infusion for postoperative analgesia in grossly obese patients. Can Anaesth Soc J 29(2): 142–147
http://www.merck.com/mmpe/lexicomp/meperidine.html Stand: 22.5.08
Shibutani K, Inchiosa MA jr, Sawada K, Bairamian M (2005) Pharmacokinetic mass of fentanyl for postoperative analgesia in lean and obese patients. Br J Anaesth 95(3): 377–383
Nelson DB, Barkun AN, Block KP et al. (2001) American society for gastrointestinal endoscopy. technology committee. Propofol use during gastrointestinal endoscopy. Gastrointest Endosc 53(7): 876–879
Riphaus A, Gstettenbauer T, Frenz MB, Wehrmann T (2006) Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study. Endosc 38(7): 677–683
Sieg A (2007) Propofol sedation in outpatient colonoscopy by trained practice nurses supervised by the gastroenterologist: a prospective evaluation of over 3000 cases. Z Gastroenterol 45(8): 697–701
Rex DK, Heuss LT, Walker JA et al. (2007) Propofol sedation during endoscopic procedures: how much staff and monitoring are necessary? Gastrointest Endosc 66(3): 443–449
Qadeer MA, Vargo JJ, Khandwala F et al. (2005) Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. Clin Gastroenterol Hepatol 3(11): 1049–1056
Servin F, Farinotti R, Haberer JP, Desmonts JM (1993) Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study. Anesthesiol 78(4): 657–665
Weaver JM (2004) Increased anesthetic risk for patients with obesity and obstructive sleep apnea. Anesth Prog 51(3): 75
von Delius S, Karagianni A, Henke J et al. (2007) Changes in intra-abdominal pressure, hemodynamics, and peak inspiratory pressure during gastroscopy in a porcine model. Endosc 39(11): 962–968
Dhariwal A, Plevris JN, Lo NT et al. (1992) Age, anemia, and obesity-associated oxygen desaturation during upper gastrointestinal endoscopy. Gastrointest Endosc 38(6): 684–688
Biddle C (1996) Comparative aspects of the airway during general anesthesia in obese sufferers of sleep apnea and matched normals. Adv Pract Nurs Q Winter 2(3): 14–19
Schröder T, Nolte M, Kox WJ, Spies C (2001) Anesthesia in extreme obesity Herz 26(3): 222–228
Schälte G, Rex S, Henzler D (2007) Airway management. Anaesthesist 56(8): 837–855
Cappell MS (2004) Safety and efficacy of colonoscopy after myocardial infarction: an analysis of 100 study patients and 100 control patients at two tertiary cardiac referral hospitals. Gastrointest Endosc 60(6): 901–909
Cappell MS, Iacovone FM jr (1999) Safety and efficacy of esophagogastroduodenoscopy after myocardial infarction. Am J Med 106(1): 29–35
Subramanian S, Liangpunsakul S, Rex DK (2005) Preprocedure patient values regarding sedation for colonoscopy. J Clin Gastroenterol 39(6): 516–519
Alami RS, Schuster R, Friedland S et al. (2007) Transnasal small-caliber esophagogastroduodenoscopy for preoperative evaluation of the high-risk morbidly obese patient. Surg Endosc 21(5): 758–760
Külling D, Orlandi M, Inauen W (2007) Propofol sedation during endoscopic procedures: how much staff and monitoring are necessary? Gastrointest Endosc 66(3): 443–449
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von Delius, S., Schmid, R. & Frimberger, E. Sedierung adipöser Patienten für die Endoskopie. Gastroenterologe 3, 378–382 (2008). https://doi.org/10.1007/s11377-008-0202-1
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DOI: https://doi.org/10.1007/s11377-008-0202-1