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Gastrointestinale Nebenwirkungen von Zytostatika

Gastrointestinal side effects of cytostatics

  • Schwerpunkt: Medikamentöse Nebenwirkungen im Gastrointestinaltrakt
  • Published:
Der Gastroenterologe Aims and scope

Zusammenfassung

Gastrointestinale Nebenwirkungen gehören zu den häufigsten und für den Patienten besonders belastenden Folgen einer zytostatischen Chemotherapie. Zu den wichtigen Nebenwirkungen gehören Nausea, Emesis, Mukositis und Diarrhö. Sie können schwerwiegende klinische Folgen haben und gefährden den Erfolg einer Chemotherapie. Die Prophylaxe und Therapie gastrointestinaler Nebenwirkungen sind integraler Bestandteil einer Tumortherapie und sollten gemäß den aktuellen Leitlinien erfolgen. Die vorliegende Arbeit fasst den aktuellen Stand zur Prophylaxe und Therapie der häufigen gastrointestinalen Chemotherapie-Nebenwirkungen zusammen.

Abstract

Gastrointestinal (GI) side effects are among the most frequent consequences of antineoplastic chemotherapy and may seriously impair patients quality of life. These side effects include nausea, emesis, mucositis and diarrhoea and may lead to hazardous clinical disturbances and jeopardize the goals of chemotherapy.

Prophylaxis and therapy of GI side effects according to clinical guidelines must therefore be an integral part of any chemotherapy. This review summarizes the current concepts on the therapy of GI side effects.

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Literatur

  1. Ballatori E, Roila F (2003) Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy. Health Qual Life Outcomes 1: 46

    Article  PubMed  Google Scholar 

  2. Clarkson J (2005) Palifermin improves oral mucositis after high dose chemotherapy and radiotherapy plus stem cell transplantation in people with haematological cancers. Cancer Treat Rev 31: 413–416

    Article  PubMed  Google Scholar 

  3. Clarkson JE, Worthington HV, Eden OB (2003) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev CD000978

  4. Epstein JB, Klasser GD (2006) Emerging approaches for prophylaxis and management of oropharyngeal mucositis in cancer therapy. Expert Opin Emerg Drugs 11: 353–373

    Article  PubMed  Google Scholar 

  5. Gibson RJ, Keefe DM (2006) Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Support Care Cancer

  6. Herrstedt J, Koeller JM, Roila F et al. (2005) Acute emesis: moderately emetogenic chemotherapy. Support Care Cancer 13: 97–103

    Article  PubMed  Google Scholar 

  7. Kris MG, Hesketh PJ, Herrstedt J et al. (2005) Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy. Support Care Cancer 13: 85–96

    Article  PubMed  Google Scholar 

  8. McGuire DB, Correa ME, Johnson J, Wienandts P (2006) The role of basic oral care and good clinical practice principles in the management of oral mucositis. Support Care Cancer

  9. Roila F, Fatigoni S (2006) New antiemetic drugs. Ann Oncol 17 [Suppl 2]: ii96–ii100

    Article  PubMed  Google Scholar 

  10. Roila F, Hesketh PJ, Herrstedt J (2006) Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference. Ann Oncol 17: 20–28

    Article  PubMed  Google Scholar 

  11. Roila F, Warr D, Clark-Snow RA et al. (2005) Delayed emesis: moderately emetogenic chemotherapy. Support Care Cancer 13: 104–108

    Article  PubMed  Google Scholar 

  12. Rubenstein EB, Peterson DE, Schubert M et al. (2004) Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100: 2026–2046

    Article  PubMed  Google Scholar 

  13. Seegenschmiedt MH (1998) Interdisciplinary documentation of treatment side effects in oncology. Present status and perspectives. Strahlenther Onkol 174 [Suppl 3]: 25–29

    Google Scholar 

  14. Seegenschmiedt MH et al. (1999) Dokumentation von Nebenwirkungen in der Onkologie. Dtsch Arztebl 96(8): 384–389

    Google Scholar 

  15. Sonis ST, Elting LS, Keefe D et al. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100: 1995–2025

    Article  PubMed  Google Scholar 

  16. Spielberger R, Stiff P, Bensinger W et al. (2004) Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 351: 2590–2598

    Article  PubMed  Google Scholar 

  17. Tonato M, Clark-Snow RA, Osoba D et al. (2005) Emesis induced by low or minimal emetic risk chemotherapy. Support Care Cancer 13: 109–111

    Article  PubMed  Google Scholar 

  18. Worthington H, Clarkson J, Eden O (2006) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev CD000978

  19. Seegenschmiedt MH (1998) Nebenwirkungen in der Onkologie. Springer, Berlin Heidelberg New York

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Rost, D., Riemann, J.F. Gastrointestinale Nebenwirkungen von Zytostatika. Gastroenterologe 1, 209–214 (2006). https://doi.org/10.1007/s11377-006-0027-8

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  • DOI: https://doi.org/10.1007/s11377-006-0027-8

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