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Journal of Biomedical Science

, Volume 15, Issue 5, pp 565–576 | Cite as

Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond

  • Jin-Ying Lu
  • Kuo-Chin Huang
  • Lin-Chau Chang
  • Ying-Shing Huang
  • Yu-Chiao Chi
  • Ta-Chan Su
  • Chi-Ling Chen
  • Wei-Shiung YangEmail author
Review

Abstract

Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many other human diseases. From animal experiments and human studies, adiponectin has been shown to be a key regulator of insulin sensitivity. In this article, we review the evidence and propose that hypo-adiponectinemia is not a major cause of obesity. Instead, it is the result of obesity-induced insulin resistance in the adipose tissue. Hypo-adiponectinemia then mediates the metabolic effects of obesity on the other peripheral tissues, such as liver and skeletal muscle and may also exert some direct effects on end-organ damage. We propose that deciphering the molecular details governing the adiponectin gene expression and protein secretion will lead us to more comprehensive understanding of the mechanisms of insulin resistance in the adipose tissue and provide us new avenues for the therapeutic intervention of obesity and insulin resistance-related human disorders

Keywords

Adiponectin Obesity Insulin resistance Adipcytokines Metabolic syndrome 

Abbreviations

DM

Diabetes mellitus

MetS

Metabolic syndrome

TNF

Tumor necrosis factor

IL

Interleukin

POMC

Pro-opiomelanocortin

NP-Y

Neuropeptide-Y

AMPK

AMP-activated protein kinase

PPAR

Peroxisome proliferators-activated receptor

KO

Knockout

HIV

Human immunodeficiency virus

WT

Wild-type

CCl4

Carbon tetrachloride

TGF

Transforming growth factor

CAD

Coronary artery disease

PCOS

Polycystic ovary syndrome

BMD

Bone mineral density

PPRE

PPAR response element

mTOR

Mammalian target of rapamycin

DAG

Diacylglycerol

PKC

Protein kinase C

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Copyright information

© National Science Council Taipei 2008

Authors and Affiliations

  • Jin-Ying Lu
    • 1
    • 2
    • 3
  • Kuo-Chin Huang
    • 4
  • Lin-Chau Chang
    • 3
  • Ying-Shing Huang
    • 3
  • Yu-Chiao Chi
    • 3
  • Ta-Chan Su
    • 2
  • Chi-Ling Chen
    • 3
  • Wei-Shiung Yang
    • 2
    • 3
    • 4
    Email author
  1. 1.Department of Laboratory MedicineNational Taiwan University HospitalTaipeiTaiwan, ROC
  2. 2.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan, ROC
  3. 3.Graduate Institute of Clinical Medicine, College of MedicineNational Taiwan UniversityTaipeiTaiwan, ROC
  4. 4.Department of Family MedicineNational Taiwan University HospitalTaipeiTaiwan, ROC

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