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Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children

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Journal of Biomedical Science

Abstract

This study tested whether there were different expressions of gastric Lewis antigens between children and adults with Helicobacter pylori infection, and whether the difference was related to the infection outcome. About 68 dyspeptic children and 110 dyspeptic adults were enrolled to check H. pylori infection, its colonization density, and the related histology. Gastric Lewis antigens b (Leb), x (Lex), and sialyl-Lewis x (sialyl-Lex) were immunohistochemically stained and scored for the intensity. The H. pylori-infected adults, but not the children, had a lower Leb intensity over the antrum (p = 0.019) but higher Leb intensity over the corpus (p = 0.001) than the non-infected ones. Over the antrum, both the H. pylori-infected children and adults had a lower Lex and higher sialyl-Lex intensity than those non-infected ones (p < 0.05). The H. pylori-infected adults had a higher bacterial density (p = 0.004) and Leb intensity (p = 0.016) over the corpus than the H. pylori-infected children. For the H. pylori-infected adults, but not children, the corpus had a higher Leb (p = 0.038) and lower Lex (p = 0.005) intensity than the antrum. Furthermore, the H. pylori-infected adults expressed a higher Leb and had a higher bacterial density than those with weak Leb (antrum, p < 0.001; corpus, p = 0.001). In conclusion, H. pylori infection is associated with the intensity change of Lewis antigen expressions in the stomach. The changes of gastric Lewis antigen expressions are different between adults and children with H. pylori infection, which may exert different H. pylori colonization over the corpus between adults and children.

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Acknowledgements

The study was supported by grants NSC93–2314-B-006-064, NSC94-2314-B-006-001, NSC94-2314-B-006-013 and NSC94-2314-B-006-062 from the National Science Council, and NCKUH 95-064 from National Cheng Kung University Hospital, Taiwan.

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Authors and Affiliations

  1. Department of Pediatrics, National Cheng Kung University, Tainan, Taiwan

    Yao-Jong Yang

  2. Institutes of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan

    Yao-Jong Yang & Bor-Shyang Sheu

  3. Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan

    Jiunn-Jong Wu

  4. Institutes of Basic Medical Science, Medical College, National Cheng Kung University, Tainan, Taiwan

    Jiunn-Jong Wu

  5. Department of Internal Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan

    Bor-Shyang Sheu

  6. Department of Pathology, National Cheng Kung University, Tainan, Taiwan

    Chia-Ru Chen, Cheng-Chang Lu & Hsiao-Bai Yang

  7. Department of Pathology, Private To-Yen Hospital, Hsin-Chu, Taiwan

    Hsiao-Bai Yang

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  1. Yao-Jong Yang
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  2. Jiunn-Jong Wu
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  6. Hsiao-Bai Yang
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Correspondence to Bor-Shyang Sheu.

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Yang, YJ., Wu, JJ., Sheu, BS. et al. Helicobacter pylori infection can change the intensity of gastric Lewis antigen expressions differently between adults and children. J Biomed Sci 15, 29–36 (2008). https://doi.org/10.1007/s11373-007-9202-2

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  • DOI: https://doi.org/10.1007/s11373-007-9202-2

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