Summary
Smokeless tobacco (ST) is widely used as chewing tobacco and as oral snuff in the world. Also, in Kahramanmaraş, a city in Southern Turkey, ST used as ‘oral powder’ or ‘Maraş Powder’ is consumed widely instead of cigarette smoking. The aim of this study was to search the effect of ST use on serum total sialic acid (TSA) and to compare the serum TSA levels in smokers and ST users. The study was performed at the Department of Chemistry-Biochemistry, University of Kahramamaraş Sutcu Imam, Turkey, in 2003. Serum samples obtained from smokers (Group I), Maraş powder users (Group II), and healthy control subjects (Group III) who were nonsmokers and nonusers ST. Individuals who were smokers and ST users were classified into subgroups with respect to amount of consumed cigarette or oral powder. Serum TSA was measured with the Denny’s colorimetric method. The TSA concentrations were significantly higher in the sera of smokers (p < 0.001) and Maraş powder users (p < 0.001) than those of control subjects. The mean serum TSA level was found to be lowest in the control group and highest in the Maraş Powder users. But, there was no significant difference in serum TSA levels between smokers and Maraş powder users (p > 0.05). We can conclude from the results obtained that serum TSA was affected by ST use as seen in smokers. This finding may be an indication of harmful effects of ST use as Maraş powder as well as cigarette smoking.
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E.J. Jensen B. Pedersen R. Frederiksen R. Dahl (1998) ArticleTitleProspective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function Thorax 53 784–789 Occurrence Handle10319062
A.D. Blann U. Kirkpatrick C. Devine S. Naser C.N. Mccollum (1998) ArticleTitleThe influence of acute smoking on leucocytes, platelets and the endothelium Atherosclerosis 141 133–139 Occurrence Handle9863546
M.S. Latha P.L. Vijayammal P.A. Kurup (1991) ArticleTitleChanges in the glycosaminoglycans and glycoproteins in the tissues in rats exposed to cigarette smoke Atherosclerosis 31 49–54
A.M. Idris S.O. Ibrahim E.N. Vasstrand et al. (1998) ArticleTitleThe Swedish Snus and the Sudanese Toombak: are they different? Oral Oncol. 34 558–566 Occurrence Handle9930371
Y. Ozkul H. Donmez A. Erenmemisoglu H. Demirtas N. Imamoglu (1997) ArticleTitleInduction of micronuclei by smokeless tobacco on buccal mucosa cells of habitual users Mutagenesis 12 285–287 Occurrence Handle9237775
InstitutionalAuthorNameIARC International Agency for Research on Cancer (1985) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans NumberInSeries37 Tobacco Habits other than Smoking; Betel Quid and Areca-nut Chewing; and some Related Nitrosamines France
E. Kökoğlu H. Sönmez E. Uslu I. Uslu (1992) ArticleTitleSialic acid levels in various types of cancer Cancer Biochem. Biophys. 13 IssueID1 57–64 Occurrence Handle1343847
M. Crook (1993) ArticleTitleThe determination of plasma or serum sialic acid Clin. Biochem. 26 31–38 Occurrence Handle8448836
G. Lindberg L. Råstam B. Gullberg G.A. Eklund S. Tgörnberg (1991) ArticleTitleSerum sialic acid concentration and smoking: a population based study BMJ 303 1306–1307 Occurrence Handle1747673
G. Lindberg G.A. Eklund B. Gullberg (1991) ArticleTitleSerum sialic acid concentration and cardiovascular mortality BMJ 302 143–146 Occurrence Handle1995133
P. Sillanaukee M. Pönniö I.P. Jaaskelainen (1999) ArticleTitleOccurrence of sialic acids in healthy humans and different disorders Eur J Clin Invest 29 IssueID5 413–425 Occurrence Handle10354198
P.J. Waters E. Lewry C.A. Pennock (1992) ArticleTitleMeasurement of sialic acid in serum and urine: clinical applications and limitations Ann. Clin. Biochem. 29 625–637 Occurrence Handle1489159
K. Erbil J.D. Jones G.G. Klee (1985) ArticleTitleUse and limitations of serum total and lipid-bound sialic acid concentrations as markers for colorectal cancer Cancer 55 404–409 Occurrence Handle3965096
P.C. Denny P.A. Denny S.E. Allerton (1983) ArticleTitleDetermination of sialic acid using 2-thiobarbituric acid in the absence of␣hazardous sodium arsenite Clin. Chim. Acta 131 IssueID3 333–336 Occurrence Handle6688384
D. Aminoff (1961) ArticleTitleMethods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids Biochem. J. 81 384–392 Occurrence Handle13860975
L. Warren (1959) ArticleTitleThe thiobarbituric acid assay of sialic acids J.␣Biol. Chem. 234 1971–1975 Occurrence Handle13672998
M.A. Mendall P. Patel M. Asante L. Ballam J. Morris D.P. Strachan A.J. Camm (1997) ArticleTitleRelation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease Heart 78 273–277 Occurrence Handle9391290
G. Lindberg L. Råstam B. Gullberg A. Lundblad P. Nilsson-Ehle B.S. Hanson (1993) ArticleTitleSerum concentrations of total sialic acid and sialoglycoproteins in relation to coronary heart disease risk markers Atherosclerosis 103 123–129 Occurrence Handle7507325
P.S. Patel G.N. Raval R.M. Rawal Patel G.H. D.B. Balar P.M. Shah D.D. Patel (1994) ArticleTitleAssessing benefits of combining biochemical and immunological markers in patients with lung carcinoma Cancer Lett. 82 129–133 Occurrence Handle8050082
J. Cluette-Brown J. Mulligan K. Doyle S. Hagan T. Osmolski J. Hojnocki (1986) ArticleTitleOral nicotine induces an atherogenic lipoprotein profile Proc. Soc. Exp. Biol. Med. 182 409–413 Occurrence Handle3714724
M.S. Latha P.L. Vijayammal P.A. Kurup (1993) ArticleTitleEffect of nicotine administration on lipid metabolism in rats Indian J. Med. Res. 98 44–49 Occurrence Handle8495991
F. Saitoh M. Noma N. Kawashima (1985) ArticleTitleThe alkaloid contents of sixty nicotine species Phytochemistry 24 477–480
D. Hoffmann M.Y. Djordjevic (1997) ArticleTitleChemical composition and carcinogenicity of smokeless tobacco Adv. Dent. Res. 11 IssueID3 322–329 Occurrence Handle9524432
Department of Health and Human Services. The health consequences of using smokeless tobacco. DHH Publication No.86–2874, Bethesda, MD, National Cancer Institute, 1986
Brunnemann K.D. and Hoffmann D. Chemical composition of smokeless tobacco products. In: Smokeless Tobacco or Health, Vol. 2. National Cancer Institute Monographs, 1992, pp. 96–108
D. Hoffmann J.D. Adams D. Lisk I. Fisenne K.D. Brunnemann (1987) ArticleTitleToxic and carcinogenic agents in dry and moist snuff JNCI 79 IssueID6 1281–1286 Occurrence Handle3480379
M.C. Plucinsky W.M. Riley J.J. Prorok J.A. Alhadeff (1986) ArticleTitleTotal and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement Cancer 58 2680–2685 Occurrence Handle3779617
T. Sata J. Roth C. Zuber B. Stamm P.U. Heitz (1991) ArticleTitleExpression of alpha 2,6-linked sialic acid residues in neoplastic but non in normal human colonic mucosa. A lectin-gold cytochemical study with Sambucus nigra and Maackia amurensis lectins Am. J. Pathol. 139 1435–1448 Occurrence Handle1661075
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Kurtul, N., Çil, M.Y. & Paçacı ı, S.D. Serum total sialic acid levels in smokers and users of smokeless tobacco in form of oral powder (Maraş powder). J Biomed Sci 12, 559–563 (2005). https://doi.org/10.1007/s11373-005-4563-x
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DOI: https://doi.org/10.1007/s11373-005-4563-x