Abstract
Bidens pilosa is claimed to be useful for immune or anti-inflammatory disorders; however, little scientific evidence has been published concerning its function. In this paper, immune disease mouse models were used to study the function of a butanol fraction of B.pilosa. We demonstrated treatment with the butanol fraction of B.pilosa ameliorated Th1 cell-mediated autoimmune diabetes in nonobese diabetic (NOD) mice but caused deterioration of Th2 cell-mediated airway inflammation induced by ovalbumin (OVA) in BALB/c mice. We next showed that Th2 cytokines (IL-4 and/or IL-5) increased but Th1 cytokine (IFN-γ) decreased following injections with the butanol fraction of B.pilosa in both mouse strains. Accordingly, Th2 cytokine-regulated IgE production in mouse serum increased following treatment with this fraction. Finally, we found that the butanol fraction of B.pilosa inhibited Th1 cell differentiation but promoted Th2 cell differentiation. Taken together, the butanol fraction of B.pilosa has a dichotomous effect on helper T cell-mediated immune disorders, plausibly via modulation of T cell differentiation.
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References
A.K. Abbas K.M. Murphy A. Sher (1996) ArticleTitleFunctional diversity of helper T lymphocytes Nature 383 787–793 Occurrence Handle10.1038/383787a0 Occurrence Handle1:CAS:528:DyaK28XmsF2qsLY%3D Occurrence Handle8893001
L. Castano G.S. Eisenbarth (1990) ArticleTitleType-I diabetes: a chronic autoimmune disease of human, mouse, and rat Annu. Rev. Immunol. 8 647–679
J.D. Katz C. Benoist D. Mathis (1995) ArticleTitleT helper cell subsets in insulin-dependent diabetes Science 268 1185–1188 Occurrence Handle1:CAS:528:DyaK2MXlvVyqsL8%3D Occurrence Handle7761837
H. Toyoda B. Formby (1998) ArticleTitleContribution of T cells to the development of autoimmune diabetes in the NOD mouse model Bioessays 20 750–757
S.H. Gavett X. Chen F. Finkelman M. Wills-Karp (1994) ArticleTitleDepletion of murine CD4+ T lymphocytes prevents antigeninduced airway hyperreactivity and pulmonary eosinophilia Am. J. Respir. Cell. Mol. Biol. 10 587–593
E. Hamelmann A. Oshiba J. Loader G.L. Larsen G. Gleich J. Lee E.W. Gelfand (1997) ArticleTitleAntiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization Am. J. Respir. Crit. Care Med. 155 819–825
E. Hamelmann K. Takeda A. Haczku G. Cieslewicz L. Shultz Q. Hamid Z. Xing J. Gauldie E.W. Gelfand (2000) ArticleTitleInterleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice Am. J. Respir. Cell Mol. Biol. 23 327–334
S.P. Hogan A. Koskinen K.I. Matthaei I.G. Young P.S. Foster (1998) ArticleTitleInterleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice Am. J. Respir. Crit. Care. Med. 157 210–218
J.A. Gonzalo C.M. Lloyd L. Kremer E. Finger A.C. Martinez M.H. Siegelman M. Cybulsky J.C. Gutierrez-Ramos (1996) ArticleTitleEosinophil recruitment to the lung in a murine model of allergic inflammation The role of T cells, chemokines, and adhesion receptors. J. Clin. Invest. 98 2332–2345
E. Hamelmann K. Takeda J. Schwarze A.T. Vella C.G. Irvin E.W. Gelfand (1998) ArticleTitleDevelopment of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes Am. J. Respir. Cell. Mol. Biol. 21 480–489
J.A. MacLean A. Sauty A.D. Luster J.M. Drazen G.T. De Sanctis (1999) ArticleTitleAntigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice Am. J. Respir. Cell. Mol. Biol. 20 379–387
K. Takeda E. Hamelmann A. Joetham L.D. Shultz G.L. Larsen C.G. Irvin E.W. Gelfand (1997) ArticleTitleDevelopment of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice J. Exp. Med. 186 449–454
M. Wills-Karp (1999) ArticleTitleImmunologic basis of antigen-induced airway hyperresponsiveness Annu. Rev. Immunol. 17 255–281
M.G. Brandao A.U. Krettli L.S. Soares C.G. Nery H.C. Marinuzzi (1997) ArticleTitleAntimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds J. Ethnopharmacol. 57 131–138
H.W. Chih C.C. Lin K.S. Tang (1995) ArticleTitleAnti-inflammatory activity of Taiwan folk medicine ‘ham-hong-chho’ in rats Am. J. Chin. Med. 23 273–278
P. Geissberger U. Sequin (1991) ArticleTitleConstituents of Bidens pilosa L. : do the components found so far explain the use of this plant in traditional medicine? Acta Trop. 48 251–261
A.K. Jager A. Hutchings J. Staden Particlevan (1996) ArticleTitleScreening of Zulu medicinal plants for prostaglandin-synthesis inhibitors J. Ethnopharmacol. 52 95–100
R.L. Pereira T. Ibrahim L. Lucchetti A.J. da Silva V.L. Goncalvesde Moraes (1999) ArticleTitleImmunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L Immunopharmacology 43 31–37
T. Rabe J. Staden Particlevan (1997) ArticleTitleAntibacterial activity of South African plants used for medicinal purposes J. Ethnopharmacol. 56 81–87
R.P. Ubillas C.D. Mendez S.D. Jolad J. Luo S.R. King T.J. Carlson D.M. Fort (2000) ArticleTitleAntihyperglycemic acetylenic glucosides from Bidens pilosa Planta Med. 66 82–83
S.L. Chang C.L. Chang Y.M. Chiang R.H. Hsieh C.R. Tzeng T.K. Wu H.K. Sytwu L.F. Shyur W.C. Yang (2004) ArticleTitlePolyacetylenic compounds and butanol fraction from Bidens pilosacan modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice Planta Med. 70 1045–1051
A. Iwata K. Nishio R.K. Winn E.Y. Chi W.R. Henderson SuffixJr. J.M. Harlan (2003) ArticleTitleA broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model J. Immunol. 170 3386–3391
A. Mathew J.A. MacLean E. DeHaan A.M. Tager F.H. Green A.D. Luster (2001) ArticleTitleSignal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation J. Exp. Med. 193 1087–1096
M. Grattan Q.S. Mi C. Meagher T.L. Delovitch (2002) ArticleTitleCongenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci Diabetes 51 215–223
J.D. Peterson B. Pike M. McDuffie K. Haskins (1994) ArticleTitleIslet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice J. Immunol. 153 2800–2806
E.S. Hwang A. Choi I.C. Ho (2002) ArticleTitleTranscriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1 J. Immunol. 169 248–253
W.C. Yang K.A. Ching C.D. Tsoukas L.J. Berg (2001) ArticleTitleTec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain J. Immunol. 166 387–395
S. Sreenan A.J. Pick M. Levisetti A.C. Baldwin W. Pugh K.S. Polonsky (1999) ArticleTitleIncreased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse Diabetes 48 989–996 Occurrence Handle1:CAS:528:DyaK1MXjtFSgsbs%3D Occurrence Handle10331402
M.G. Valorani M.I. Hawa L.R. Buckley A. Afeltra F. Cacciapaglia P. Pozzilli (2004) ArticleTitleThe natural history of insulin content in the pancreas of female and male non-obese diabetic mouse: implications for trials of diabetes prevention in humans Diabetes Metab. Res. Rev. 20 394–398
R.H. DeKruyff L.V. Rizzo D.T. Umetsu (1993) ArticleTitleInduction of immunoglobulin synthesis by CD4+ T cell clones Semin Immunol. 5 421–430
N. Kai K. Motojima T. Tsunoda T. Kanematsu (1993) ArticleTitlePrevention of insulitis and diabetes in nonobese diabetic mice by administration of FK506 Transplantation 55 936–940
D.F. Mayer S.S. Kushwaha (2003) ArticleTitleTransplant immunosuppressant agents and their role in autoimmune rheumatic diseases Curr. Opin. Rheumatol. 15 219–225
S. Kawamoto Y. Nitta F. Tashiro A. Nakano E. Yamato H. Tahara K. Tabayashi J. Miyazaki (2001) ArticleTitleSuppression of T(h)1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10 Int. Immunol. 13 685–694
K.S. Ko M. Lee J.J. Koh S.W. Kim (2001) ArticleTitleCombined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice Mol. Ther. 4 313–316
S. Trembleau G. Penna S. Gregori M.K. Gately L. Adorini (1997) ArticleTitleDeviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes Eur. J. Immunol 27 2330–2339
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Chang, C.LT., Kuo, HK., Chang, SL. et al. The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. J Biomed Sci 12, 79–89 (2005). https://doi.org/10.1007/s11373-004-8172-x
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DOI: https://doi.org/10.1007/s11373-004-8172-x