Aurisano N, Huang L, Mila i Canals L, Jolliet O, Fantke P (2021) Chemicals of concern in plastic toys. Environ. Int. 146:106194. https://doi.org/10.1016/j.envint.2020.106194
CAS
Article
Google Scholar
Chiu WA, Slob W (2015) A unified probabilistic framework for dose-response assessment of human health effects. Environ. Health Perspect. 123:1241–1254. https://doi.org/10.1289/ehp.1409385
Article
Google Scholar
Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli G (2018) Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. Environ. Health Perspect. 126:1–14. https://doi.org/10.1289/EHP3368
Article
Google Scholar
Crenna E, Jolliet O, Collina E, Sala S, Fantke P (2020) Characterizing honey bee exposure and effects from pesticides for chemical prioritization and life cycle assessment. Environ. Int. 138:105642. https://doi.org/10.1016/j.envint.2020.105642
CAS
Article
Google Scholar
Csiszar SA, Ernstoff AS, Fantke P, Meyer DE, Jolliet O (2016) High-throughput exposure modeling to support prioritization of chemicals in personal care products. Chemosphere 163:490–498. https://doi.org/10.1016/j.chemosphere.2016.07.065
CAS
Article
Google Scholar
Csiszar SA, Ernstoff AS, Fantke P, Jolliet O (2017) Stochastic modeling of near-field exposure to parabens in personal care products. J. Expos. Sci. Environ. Epidemiol. 27:152–159. https://doi.org/10.1038/jes.2015.85
CAS
Article
Google Scholar
EC (2008) Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 Commission of the European Communities Brussels 1355
Ernstoff A, Niero M, Muncke J, Trier X, Rosenbaum RK, Hauschild M, Fantke P (2019) Challenges of including human exposure to chemicals in food packaging as a new exposure pathway in life cycle impact assessment Int. J. Life Cycle Assess. 24:543–552. https://doi.org/10.1007/s11367-018-1569-y
CAS
Article
Google Scholar
Ernstoff AS, Fantke P, Csiszar SA, Henderson AD, Chung S, Jolliet O (2016) Multi-pathway exposure modelling of chemicals in cosmetics with application to shampoo. Environ. Int. 92–93:87–96. https://doi.org/10.1016/j.envint.2016.03.014
CAS
Article
Google Scholar
Ernstoff AS, Fantke P, Huang L, Jolliet O (2017) High-throughput migration modelling for estimating exposure to chemicals in food packaging in screening and prioritization tools. Food Chem. Toxicol. 109:428–438. https://doi.org/10.1016/j.fct.2017.09.024
CAS
Article
Google Scholar
Fantke P, Jolliet O, Apte JS, Cohen AJ, Evans JS, Hänninen OO, Hurley F, Jantunen MJ, Jerrett M, Levy JI, Loh MM, Marshall JD, Miller BG, Preiss P, Spadaro JV, Tainio M, Tuomisto JT, Weschler CJ, McKone TE (2015) Health effects of fine particulate matter in life cycle impact assessment: conclusions from the Basel guidance workshop. Int. J. Life Cycle Assess. 20:276–288. https://doi.org/10.1007/s11367-014-0822-2
CAS
Article
Google Scholar
Fantke P, Ernstoff AS, Huang L, Csiszar SA, Jolliet O (2016) Coupled near-field and far-field exposure assessment framework for chemicals in consumer products. Environ. Int. 94:508–518. https://doi.org/10.1016/j.envint.2016.06.010
CAS
Article
Google Scholar
Fantke P, Jolliet O (2016) Life cycle human health impacts of 875 pesticides. Int. J. Life Cycle Assess. 21:722–733. https://doi.org/10.1007/s11367-015-0910-y
CAS
Article
Google Scholar
Fantke P, Jolliet O, Apte JS, Hodas N, Evans J, Weschler CJ, Stylianou KS, Jantunen M, McKone TE (2017) Characterizing aggregated exposure to primary particulate matter: recommended intake fractions for indoor and outdoor sources. Environ. Sci. Technol. 51:9089–9100. https://doi.org/10.1021/acs.est.7b02589
CAS
Article
Google Scholar
Fantke P, Aurisano N, Backhaus T, Bulle C, Chapman PM, Cooper CA, De Zwart D, Dwyer R, Ernstoff A, Golsteijn L, Henderson A, Holmquist H, Jolliet O, Kirchhübel N, Nordheim E, Otte N, Owsianiak M, Peijnenburg W, Posthuma L, Roos S, Saouter E, Schowanek D, van Straalen N, Vijver M, Hauschild M (2018a) Toward harmonizing ecotoxicity characterization in life cycle impact assessment. Environ. Toxicol. Chem. 37:2955–2971. https://doi.org/10.1002/etc.4261
CAS
Article
Google Scholar
Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, Miller A, Paoli G, Price P, Rhomberg L, Shen B, Shin H-M, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE (2018b) Advancements in life cycle human exposure and toxicity characterization. Environ. Health Perspect. 126:125001. https://doi.org/10.1289/EHP3871
CAS
Article
Google Scholar
Fantke P, Aylward L, Chiu W, Gouin T, Jolliet O, Judson R, Rhomberg L, McKone TE (2019a) Human toxicity. In: Frischknecht R, Jolliet O (eds) Global Guidance on Environmental Life Cycle Impact Assessment Indicators, vol 2. UNEP/SETAC Life Cycle Initiative. Paris, France, pp 80–103
Google Scholar
Fantke P, Illner N (2019) Goods that are good enough: introducing an absolute sustainability perspective for managing chemicals in consumer products. Curr. Opin. Green Sustain. Chem. 15:91–97. https://doi.org/10.1016/j.cogsc.2018.12.001
Article
Google Scholar
Fantke P, McKone TE, Tainio M, Jolliet O, Apte JS, Stylianou KS, Illner N, Marshall JD, Choma EF, Evans JS (2019b) Global effect factors for exposure to fine particulate matter. Environ. Sci. Technol. 53:6855–6868. https://doi.org/10.1021/acs.est.9b01800
CAS
Article
Google Scholar
Fantke P, Aurisano N, Provoost J, Karamertzanis PG, Hauschild M (2020a) Toward effective use of REACH data for science and policy. Environ. Int. 135:105336. https://doi.org/10.1016/j.envint.2019.105336
Article
Google Scholar
Fantke P, Huang L, Overcash M, Griffing E, Jolliet O (2020b) Life cycle based alternatives assessment (LCAA) for chemical substitution. Green Chem. 22:6008–6024. https://doi.org/10.1039/D0GC01544J
CAS
Article
Google Scholar
Frischknecht R, Fantke P, Tschümperlin L, Niero M, Antón A, Bare J, Boulay A-M, Cherubini F, Hauschild MZ, Henderson A, Levasseur A, McKone TE, Michelsen O, Mila y Canals L, Pfister S, Ridoutt B, Rosenbaum RK, Verones F, Vigon B, Jolliet O, (2016) Global guidance on environmental life cycle impact assessment indicators: progress and case study. Int. J. Life Cycle Assess. 21:429–442. https://doi.org/10.1007/s11367-015-1025-1
Article
Google Scholar
Frischknecht R, Jolliet O (2019) Global Guidance on Environmental Life Cycle Impact Assessment Indicators:, vol 2. UNEP/SETAC Life Cycle Initiative, Paris, France
Google Scholar
Gentil C, Fantke P, Mottes C, Basset-Mens C (2020) Challenges and ways forward in pesticide emission and toxicity characterization modeling for tropical conditions. Int J Life Cycle Assess 25:1290–1306. https://doi.org/10.1007/s11367-019-01685-9
CAS
Article
Google Scholar
Hauschild MZ, Huijbregts MAJ, Jolliet O, MacLeod M, Margni MD, van de Meent D, Rosenbaum RK, McKone TE (2008) Building a model based on scientific consensus for life cycle impact assessment of chemicals: the search for harmony and parsimony. Environ. Sci. Technol. 42:7032–7037. https://doi.org/10.1021/es703145t
CAS
Article
Google Scholar
Hay SI, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, Abdulkader RS, Abdulle AM, Abebo TA, Abera SF et al (2017) Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet 390:1260–1344. https://doi.org/10.1016/S0140-6736(17)32130-X
Article
Google Scholar
Hodas N, Loh M, Shin H-M, Li D, Bennett D, McKone TE, Jolliet O, Weschler CJ, Jantunen M, Lioy P, Fantke P (2016) Indoor inhalation intake fractions of fine particulate matter: review of influencing factors. Indoor Air 26:836–856. https://doi.org/10.1111/ina.12268
CAS
Article
Google Scholar
Holmquist H, Fantke P, Cousins I, Owsianiak M, Liagkouridis I, Peters G (2020) An (eco)toxicity life cycle impact assessment framework for per- and polyfluoroalkyl substances. Environ. Sci. Technol. 54:6224–6234. https://doi.org/10.1021/acs.est.9b07774
CAS
Article
Google Scholar
Huang L, Jolliet O (2016) A parsimonious model for the release of chemicals encapsulated in products. Atmos. Environ. 127:223–235. https://doi.org/10.1016/j.atmosenv.2015.12.001
CAS
Article
Google Scholar
Huang L, Ernstoff A, Fantke P, Csiszar S, Jolliet O (2017) A review of models for near-field exposure pathways of chemicals in consumer products. Sci. Total Environ. 574:1182–1208. https://doi.org/10.1016/j.scitotenv.2016.06.118
CAS
Article
Google Scholar
Huang L, Anastas N, Egeghy P, Vallero DA, Jolliet O, Bare J (2019) Integrating exposure to chemicals in building materials during use stage. Int. J. Life Cycle Assess. 24:1009–1026. https://doi.org/10.1007/s11367-018-1551-8
CAS
Article
Google Scholar
Huijbregts MAJ, Rombouts LJA, Ragas AMJ, van de Meent D (2005) Human-toxicological effect and damage factors of carcinogenic and noncarcinogenic chemicals for life cycle impact assessment. Integr. Environ. Assess. Manage. 1:181–244. https://doi.org/10.1897/2004-007R.1
CAS
Article
Google Scholar
Jolliet O, Frischknecht R, Bare J, Boulay A-M, Bulle C, Fantke P, Gheewala S, Hauschild M, Itsubo N, Margni M, McKone T, Mila y Canals L, Postuma L, Prado V, Ridoutt B, Sonneman G, Rosenbaum R, Seager T, Struis J, van Zelm R, Vigon B, Weisbrod A, (2014) Global guidance on environmental life cycle impact assessment indicators: findings of the scoping phase. Int. J. Life Cycle Assess. 19:962–967. https://doi.org/10.1007/s11367-014-0703-8
Article
Google Scholar
Jolliet O, Ernstoff AS, Csiszar SA, Fantke P (2015) Defining product intake fraction to quantify and compare exposure to consumer products. Environ. Sci. Technol. 49:8924–8931. https://doi.org/10.1021/acs.est.5b01083
CAS
Article
Google Scholar
Jolliet O, Antón A, Boulay A-M, Cherubini F, Fantke P, Levasseur A, McKone TE, Michelsen O, Milà i Canals L, Motoshita M, Pfister S, Verones F, Vigon B, Frischknecht R, (2018) Global guidance on environmental life cycle impact assessment indicators: impacts of climate change, fine particulate matter formation, water consumption and land use. Int. J. Life Cycle Assess. 23:2189–2207. https://doi.org/10.1007/s11367-018-1443-y
CAS
Article
Google Scholar
Jolliet O, Huang L, Hou P, Fantke P (2021) High throughput risk and impact screening of chemicals in consumer products. Risk Anal. https://doi.org/10.1111/risa.13604
Kirchhübel N, Fantke P (2019) Getting the chemicals right: toward characterizing toxicity and ecotoxicity impacts of inorganic substances. J. Cleaner Prod. 227:554–565. https://doi.org/10.1016/j.jclepro.2019.04.204
CAS
Article
Google Scholar
Kjeldsen P, Christensen TH (2001) A simple model for the distribution and fate of organic chemicals in a landfill: MOCLA. Waste Manage. Res. 19:201–216. https://doi.org/10.1177/0734242x0101900303
CAS
Article
Google Scholar
Margni MD, Pennington DW, Bennett DH, Jolliet O (2004) Cyclic exchanges and level of coupling between environmental media: intermedia feedback in multimedia fate models. Environ. Sci. Technol. 38:5450–5457. https://doi.org/10.1021/es049716a
CAS
Article
Google Scholar
Owsianiak M, Fantke P, Posthuma L, Saouter E, Vijver M, Backhaus T, Schlekat T, Hauschild M (2019) Ecotoxicity. In: Frischknecht R, Jolliet O (eds) Global Guidance on Environmental Life Cycle Impact Assessment Indicators, vol 2. UNEP/SETAC Life Cycle Initiative. Paris, France, pp 138–172
Google Scholar
Ring CL, Arnot J, Bennett DH, Egeghy P, Fantke P, Huang L, Isaacs KK, Jolliet O, Phillips K, Price PS, Shin H-M, Westgate JN, Setzer RW, Wambaugh JF (2019) Consensus modeling of median chemical intake for the U.S. population based on predictions of exposure pathways. Environ. Sci. Technol. 53:719–732. https://doi.org/10.1021/acs.est.8b04056
CAS
Article
Google Scholar
Rosenbaum RK, Bachmann TM, Gold LS, Huijbregts MAJ, Jolliet O, Juraske R, Koehler A, Larsen HF, MacLeod M, Margni MD, McKone TE, Payet J, Schuhmacher M, van de Meent D, Hauschild MZ (2008) USEtox - the UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in life cycle impact assessment. Int. J. Life Cycle Assess. 13:532–546. https://doi.org/10.1007/s11367-008-0038-4
CAS
Article
Google Scholar
Rosenbaum RK, Huijbregts MAJ, Henderson AD, Margni M, McKone TE, van de Meent D, Hauschild MZ, Shaked S, Li DS, Gold LS, Jolliet O (2011) USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties. Int. J. Life Cycle Assess. 16:710–727. https://doi.org/10.1007/s11367-011-0316-4
CAS
Article
Google Scholar
Rosenbaum RK, Meijer A, Demou E, Hellweg S, Jolliet O, Lam NL, Margni M, McKone TE (2015) Indoor air pollutant exposure for life cycle assessment: regional health impact factors for households. Environ. Sci. Technol. 49:12823–12831. https://doi.org/10.1021/acs.est.5b00890
CAS
Article
Google Scholar
Salomon JA, Haagsma JA, Davis A, de Noordhout CM, Polinder S, Havelaar AH, Cassini A, Devleesschauwer B, Kretzschmar M, Speybroeck N, Murray CJL, Vos T (2015) Disability weights for the Global Burden of Disease 2013 study. Lancet Global Health 3:e712–e723. https://doi.org/10.1016/S2214-109X(15)00069-8
Article
Google Scholar
Saouter E, Aschberger K, Fantke P, Hauschild MZ, Bopp SK, Kienzler A, Paini A, Pant R, Secchi M, Sala S (2017a) Improving substance information in USEtox®, Part 1: discussion on data and approaches for estimating freshwater ecotoxicity effect factors. Environ. Toxicol. Chem. 36:3450–3462. https://doi.org/10.1002/etc.3889
CAS
Article
Google Scholar
Saouter E, Aschberger K, Fantke P, Hauschild MZ, Kienzler A, Paini A, Pant R, Radovnikovic A, Secchi M, Sala S (2017b) Improving substance information in USEtox®, Part 2: data for estimating fate and ecosystem exposure factors. Environ. Toxicol. Chem. 36:3463–3470. https://doi.org/10.1002/etc.3903
CAS
Article
Google Scholar
Shin HM, Ernstoff AS, Arnot JA, Wetmore B, Csiszar SA, Fantke P, Zhang X, McKone TE, Jolliet O, Bennett DH (2015) Risk-based high-throughput chemical screening and prioritization using exposure models and in vitro bioactivity assays. Environ. Sci. Technol. 49:6760–6771. https://doi.org/10.1021/acs.est.5b00498
CAS
Article
Google Scholar
Stanaway JD, Afshin A, Gakidou E, Lim SS, Abate D, Abate KH, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F et al (2018) Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392:1923–1994. https://doi.org/10.1016/S0140-6736(18)32225-6
Article
Google Scholar
Steingrimsdottir MM, Petersen A, Fantke P (2018) A screening framework for pesticide substitution in agriculture. J. Cleaner Prod. 192:306–315. https://doi.org/10.1016/j.jclepro.2018.04.266
CAS
Article
Google Scholar
UN (2020) United Nations Sustainable Development Goals
UNEP (2015) Strategic approach to international chemicals management. United Nations Environment Programme, Geneva, Switzerland
Google Scholar
US-EPA, (1991) Guidelines for developmental toxicity risk assessment. United States - Environmental Protection Agency, Washington, D.C.
Google Scholar
Verones F, Bare J, Bulle C, Frischknecht R, Hauschild M, Hellweg S, Henderson A, Jolliet O, Laurent A, Liao X, Lindner JP, de Souza DM, Michelsen O, Patouillard L, Pfister S, Posthuma L, Prado V, Ridoutt B, Rosenbaum RK, Sala S, Ugaya C, Vieira M, Fantke P (2017) LCIA framework and cross-cutting issues guidance within the UNEP-SETAC Life Cycle Initiative. J. Cleaner Prod. 161:957–967. https://doi.org/10.1016/j.jclepro.2017.05.206
Article
Google Scholar
Wang G, Huang L, Nguyen V, Jolliet O (2016) Human exposure to household cleaning products: application of a two-field model, The International Society of Exposure Science 26th Annual Meeting, 9–13 October, 2016. The Netherlands, Utrecht, pp 825–826
Google Scholar
Westh TB, Hauschild MZ, Birkved M, Jørgensen MS, Rosenbaum RK, Fantke P (2015) The USEtox story: a survey of model developer visions and user requirements. Int. J. Life Cycle Assess. 20:299–310. https://doi.org/10.1007/s11367-014-0829-8
Article
Google Scholar
WHO (2014) Guidance document on evaluating and expressing uncertainty in hazard characterization. World Health Organization, Geneva, Switzerland
Google Scholar
WHO (2017) Guidance document on evaluating and expressing uncertainty in hazard characterization, 2nd edn. World Health Organization, Geneva, Switzerland
Google Scholar
Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I (2014) Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environ. Health Perspect. 122:499–505. https://doi.org/10.1289/ehp.1307539
Article
Google Scholar
Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA (2018) Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Eviron. Health Perspect. 126:057008. https://doi.org/10.1289/EHP2998
Article
Google Scholar
Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ (2013) Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ. Health Perspect. 121:23–31. https://doi.org/10.1289/ehp.1205687
Article
Google Scholar