Effects of the antioxidant turmeric on lipoprotein peroxides: Implications for the prevention of atherosclerosis
- 141 Downloads
Extracts from the rhyzome of Curcuma longa are widely used as food additives in India and other Asiatic and Central American countries. It has been shown that these extracts (“turmeric”), as well as “curcumin” and related phenolic compounds isolated from Curcuma, have a powerful antioxidant action when tested in in vitro systems. Moreover, previous research from our laboratories has shown significant decreases in the levels of lipid peroxides in the blood of both mice and human subjects administered “turmeric.” Our present research complements the previous data, showing that a daily intake of turmeric equivalent to 20 mg of the phenolic antioxidant curcumin for 60 days decreases the high levels of peroxidation of both the HDL and the LDL, in vivo, in 30 healthy volunteers ranging in age from 40 to 90 years. The effect was quite striking in the persons with high baseline values of peroxidized compounds in these lipoproteins, while no apparent change took place in the persons having low baseline values.
In view of current concepts on the atherogenic role played by peroxidized HDL, and especially by peroxidized LDL, as inducers of foam and smooth cell proliferation in the arterial wall, this preliminary experiment suggests that the Curcuma phenolic antioxidants, because of their high antioxidant activity and lack of toxicity, might be a useful complement to standard hypo-lipidemic drugs in the prevention and treatment of atherosclerosis.
KeywordsAtherosclerosis atherogenesis lipoperoxides LDL turmeric curcuma
Unable to display preview. Download preview PDF.
- 1.Cummins, E.M., Hayward, M.D., and Saito, S.: Differentials in active life expectancy in the older population of the United States. J. Gerontol., Social Sciences, 51B: S111–120, 1996.Google Scholar
- 3.Harman, D.: Free radical theory of aging: role of free radicals in the origination and evolution of life, aging and disease processes, in Free Radicals, Aging and Degenerative Diseases, edited by Johnson, J. E., Jr., Walford, R, Harman, D. and Miquel, J., New York, Alan R Liss, 1986, pp. 3–49.Google Scholar
- 10.Weber, H. and Miquel, J.: Antioxidant supplementation and longevity. In Nutritional Aspects of Aging, edited by Chen, L., Boca Raton, CRC Press, Vol. 1, 1986, pp. 42–49.Google Scholar
- 12.Miquel, J., Martínez, M., Diez, A., De Juan, E., Soler, A., Ramirez, A., Laborda, J. and Carrión, M.: Effects of turmeric on blood and liver lipoperoxide levels of mice: lack of toxicity. Age 18: 171–174, 1995.Google Scholar
- 13.Ramirez-Boscá, A., Soler, A., Carrión Gutiérrez, M.A., Laborda Alvarez, A. and Quintanilla Almagro, E.: Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age 18: 167–169, 1995.Google Scholar
- 22.Povear, H., Santos, C., Gammaro, R., Camara, M., and Oliveira Lima, A.: Peroxidized LDL: a new risk factor in atherosclerosis. Presented at the “International Congress on Free Radicals and Aging,” Paris, 26–28 September 1991.Google Scholar
- 24.Harman, D.: Atherosclerosis: oxidation of serum lipoproteins and its relationship to pathogenesis. Clin Res. 8: 108, 1960.Google Scholar
- 25.Yagi, K., Ohkawa, H., Ohishi, N., Yamashita, M., and Nakashima, T.: Lesion of aortic intima caused by intravenous administration of linoleic acid hydroperoxide. J. Appl. Biochem. 3: 58–67, 1981.Google Scholar
- 26.Yagi, K.: Serum lipid peroxide levels in subjects having certain diseases and aging. In CRC Handbook of Free Radicals and Antioxidants in Biomedicine, Vol. 1, edited by Miquel, J., Quintanilha, A. and Weber, H., Boca Ratón, CRC Press, 1989, pp. 223–230.Google Scholar
- 27.Santos, M. T., Valles, J. and Aznar, J.: Plasma lipid peroxides in patients with vascular disease and in middle-aged normal subjects with a high risk of atherosclerosis. In CRC Handbook of Free Radicals and Antioxidants in Biomedicine, edited by Miquel, J., Quintanilha, A. and Weber, H., Boca Raton, CRC Press, 1989, pp. 237–254.Google Scholar
- 31.Johnson, E.J.: Aging and carotene nutriture. Age 16: 59–66, 1993.Google Scholar