Fig. 1

Association between PCSK9 expression and overall survival in breast and ovarian cancer. A) Kaplan–Meier curves illustrate the association between high expression of PCSK9 and improved OS in the full cohort of breast cancer patients in the RNA-seq dataset. B) Elevated expression of PCSK9 was associated with improved OS in the Luminal B subtype of GSE96058 cohort breast cancer patients. C) PCSK9 is significantly overexpressed in breast-invasive carcinoma compared to normal breast tissue samples. D) Increased expression of PCSK9 was associated with improved prognosis among ovarian cancer patients in the RNA-seq dataset. E) Investigating gene expression differences across ovarian serous cystadenocarcinomas and normal ovarian tissue revealed a significantly increased PCSK9 expression in the tumor samples. HR, hazard ratio