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Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

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Abstract

Effort toward reproduction is often thought to negatively influence health and survival. Reproduction has been shown to influence metabolism, but the pathways and mechanisms have yet to be thoroughly elucidated. In the current experiments, our aim was to dissect the role of young and old ovarian tissues in the response to oxidative stress, through changes in liver oxidative stress response proteins. Liver proteins were analyzed in control mice at 4, 13, and 27 months of age and compared to 23-month-old mice which received young ovarian tissue transplants (intact or follicle-depleted) at 13 months of age. In control mice, of the 29 oxidative stress response proteins measured, 31% of the proteins decreased, 52% increased, and 17% were unchanged from 13 to 27 months. The greatest changes were seen during the period of reproductive failure, from 4 to 13 months of age. In transplanted mice, far more proteins were decreased from 13 to 23 months (93% in follicle-containing young ovary recipients; 62% in follicle-depleted young ovary recipients). Neither transplant group reflected changes seen in control mice between 13 and 27 months. Estradiol levels in transplant recipient mice were not increased compared with age-matched control mice. The current results suggest the presence of a germ cell- and estradiol-independent ovarian influence on aging-associated changes in the response to oxidative stress, which is manifest differently in reproductive-aged adults and post-reproductive-aged mice. The results presented here separate chronological and ovarian aging and the influence of estradiol in the response to aging-associated oxidative stress and support a novel, estradiol-independent role for the ovary in female health and survival.

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The data presented in the work are available from the corresponding author upon request.

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Acknowledgements

The authors thank Dr. Aaron Olsen, Mrs. Lisa DeSoi, and Nate Johnson for their help with the mice and Dr. Miguel Brieño-Enríquez and Dr. Suzannah Williams for the discussions and contributions regarding ovarian structure and function. Additionally, the authors thank the Utah Science Technology and Research Initiative (USTAR), the USDA ARS Poisonous Plant Research Laboratory, Utah State University, and the Utah State University, College of Veterinary Medicine and the Department of Animal, Dairy, and Veterinary Sciences.

Funding

Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under award number R15AG061795 to J.B.M. and R56AG074499 to M.M.M and J.B.M. This work was also supported by the Nathan Shock Center Pilot Funding Program and the Oklahoma Nathan Shock Center core facility under award number P30 AG050911, the Utah Agricultural Experiment Station, grant number UTA01159, Utah State University, and by the College of Veterinary Medicine, Department of Animal, Dairy and Veterinary Sciences, Utah State University.

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Authors and Affiliations

  1. College of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University, Logan, UT, 84322, USA

    Tristin L. King, Kaden B. Underwood, Kindra K. Hansen & Jeffrey B. Mason

  2. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Michael T. Kinter

  3. Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas-RS, Brazil

    Augusto Schneider

  4. College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA

    Michal M. Masternak

  5. Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland

    Michal M. Masternak

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  1. Tristin L. King
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  2. Kaden B. Underwood
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  3. Kindra K. Hansen
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  4. Michael T. Kinter
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  5. Augusto Schneider
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  6. Michal M. Masternak
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  7. Jeffrey B. Mason
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Corresponding author

Correspondence to Jeffrey B. Mason.

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Ethics approval

Animals were housed, and procedures were performed in an American Association for Accreditation of Laboratory Animal Care (AAALAC) approved facility in accordance with the National Institutes of Health and Animal Use guidelines. Animal care protocols were developed under the National Research Council guidelines found in the Guide for the Care and Use of Laboratory Animals. Protocols were approved by the Utah State University Institutional Animal Care and Use Committee (IACUC-10222).

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King, T.L., Underwood, K.B., Hansen, K.K. et al. Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice. GeroScience 46, 1159–1173 (2024). https://doi.org/10.1007/s11357-023-00865-8

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