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Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function

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Abstract

The Oklahoma Shock Nathan Shock Center is designed to deliver unique, innovative services that are not currently available at most institutions. The focus of the Center is on geroscience and the development of careers of young investigators. Pilot grants are provided through the Research Development Core to junior investigators studying aging/geroscience throughout the USA. However, the services of our Center are available to the entire research community studying aging and geroscience. The Oklahoma Nathan Shock Center provides researchers with unique services through four research cores. The Multiplexing Protein Analysis Core uses the latest mass spectrometry technology to simultaneously measure the levels, synthesis, and turnover of hundreds of proteins associated with pathways of importance to aging, e.g., metabolism, antioxidant defense system, proteostasis, and mitochondria function. The Genomic Sciences Core uses novel next-generation sequencing that allows investigators to study the effect of age, or anti-aging manipulations, on DNA methylation, mitochondrial genome heteroplasmy, and the transcriptome of single cells. The Geroscience Redox Biology Core provides investigators with a comprehensive state-of-the-art assessment of the oxidative stress status of a cell, e.g., measures of oxidative damage and redox couples, which are important in aging as well as many major age-related diseases as well as assays of mitochondrial function. The GeroInformatics Core provides investigators assistance with data analysis, which includes both statistical support as well as analysis of large datasets. The Core also has developed number of unique software packages to help with interpretation of results and discovery of new leads relevant to aging. In addition, the Geropathology Research Resource in the Program Enhancement Core provides investigators with pathological assessments of mice using the recently developed Geropathology Grading Platform.

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Funding

The services described above are supported by the Oklahoma Nathan Shock Center P30 AG050911 grand and Senior Career Research Awards 1IK6BX005238 (AR) and IK6BX005234 (HVR) from the Department of Veterans Affairs.

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Authors and Affiliations

  1. Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA

    Holly Van Remmen, Benjamin F. Miller, Michael Kinter & Ann Chiao

  2. Biochemistry & Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma, City, OK, USA

    Holly Van Remmen, Willard M. Freeman, Benjamin F. Miller, William E. Sonntag & Arlan Richardson

  3. Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Willard M. Freeman & Jonathan D. Wren

  4. Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Rheal A. Towner

  5. Department of Veterinary Pathology, Center for Veterinary Health Sciences at, Oklahoma State University, Stillwater, OK, USA

    Timothy A. Snider

  6. Oklahoma City VA Medical Center, Oklahoma City, OK, USA

    Arlan Richardson

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Van Remmen, H., Freeman, W.M., Miller, B.F. et al. Oklahoma Nathan Shock Aging Center — assessing the basic biology of aging from genetics to protein and function. GeroScience 43, 2183–2203 (2021). https://doi.org/10.1007/s11357-021-00454-7

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