Skip to main content
Log in

The AGE Presents Introduction to Geroscience video lecture series

  • Methods Paper
  • Published:
GeroScience Aims and scope Submit manuscript

Abstract

The AGE Presents Introduction to Geroscience video lecture series is a collection of high-quality didactic video lectures and associated teaching materials focused on foundational topics in aging biology. The videos are made freely available on YouTube and are targeted toward an audience familiar with concepts learned in the first year of a college undergraduate biology/biomedical major. Members of the American Aging Association also receive the original lecture slides and lecture notes, with additional course materials to be developed in the future. We expect that these lectures will enhance understanding of geroscience among the general public while also providing tools that educators can use in the classroom for high school, undergraduate, and graduate level curricula.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Sierra F, Kohanski RA. Geroscience Offers a New Model for Investigating the Links Between Aging Biology and Susceptibility to Aging-Related Chronic Diseases Public Policy & Aging Report. 2013;23:7–9. https://doi.org/10.1093/ppar/23.4.7.

    Article  Google Scholar 

  2. Sierra F, Kohanski R. Geroscience and the trans-NIH Geroscience Interest Group. GSIG Geroscience. 2017;39:1–5. https://doi.org/10.1007/s11357-016-9954-6.

    Article  PubMed  Google Scholar 

  3. Kaeberlein M. It is Time to Embrace 21st-Century Medicine. Public Policy & Aging Report. 2019;29(4):111–5. https://doi.org/10.1093/ppar/prz022.

    Article  Google Scholar 

  4. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging Cell. 2013;153:1194–217. https://doi.org/10.1016/j.cell.2013.05.039.

    Article  CAS  Google Scholar 

  5. Kaeberlein M. Translational geroscience: A new paradigm for 21st century medicine. Transl Med Aging. 2017;1(1):1–4. https://doi.org/10.1016/j.tma.2017.09.004.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature. 2013;493(7432):338–45. https://doi.org/10.1038/nature11861.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018;87:295–322. https://doi.org/10.1146/annurev-biochem-062917-012239.

    Article  CAS  PubMed  Google Scholar 

  8. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–36.

    Article  CAS  PubMed  Google Scholar 

  9. Kong CM, Lee XW, Wang X. Telomere shortening in human diseases. FEBS J. 2013;280:3180–93. https://doi.org/10.1111/febs.12326.

    Article  CAS  PubMed  Google Scholar 

  10. Allis CD, Jenuwein T. The molecular hallmarks of epigenetic control. Nat Rev Genet. 2016;17:487–500. https://doi.org/10.1038/nrg.2016.59.

    Article  CAS  PubMed  Google Scholar 

  11. Liu Z, Kuo P-L, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study PLOS Medicine. 2019;15: e1002718. https://doi.org/10.1371/journal.pmed.1002718.

    Article  Google Scholar 

  12. Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19:371–84. https://doi.org/10.1038/s41576-018-0004-3.

    Article  CAS  PubMed  Google Scholar 

  13. Harman D. Aging: a theory based on free radical and radiation chemistry. Journal Gerontol. 1956;11(3):298–300.

    Article  CAS  Google Scholar 

  14. Perez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, Richardson A. Is the oxidative stress theory of aging dead? Biochim Biophys Acta. 2009;1790:1005–14. https://doi.org/10.1016/j.bbagen.2009.06.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010;5:99–118. https://doi.org/10.1146/annurev-pathol-121808-102144.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Baker DJ, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genet. 2004;36(7):744–9.

    Article  CAS  PubMed  Google Scholar 

  17. Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232–6. https://doi.org/10.1038/nature10600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Research Ther. 2019;10(1):68. https://doi.org/10.1186/s13287-019-1165-5.

    Article  CAS  Google Scholar 

  19. Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development. 2016;143(1):3–14. https://doi.org/10.1242/dev.130633.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Zhang H, et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016;352(6292):1436–43. https://doi.org/10.1126/science.aaf2693.

    Article  CAS  PubMed  Google Scholar 

  21. Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012;10:515–9. https://doi.org/10.1016/j.stem.2012.04.002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Park JH, et al. Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells. Exp Mol Med. 2020;52(1):615–28. https://doi.org/10.1038/s12276-020-0374-4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Mattson MP. Hormesis defined Ageing Res Rev. 2008;7:1–7. https://doi.org/10.1016/j.arr.2007.08.007.

    Article  CAS  PubMed  Google Scholar 

  24. Miller HA, Dean ES, Pletcher SD, Leiser SF. Cell non-autonomous regulation of health and longevity. Elife. 2020;10(9):e62659. https://doi.org/10.7554/eLife.62659.

    Article  Google Scholar 

Download references

Acknowledgements

The AGE Presents Introduction to Geroscience lecture series was supported by the Nathan Shock Centers of Excellence in the Basic Biology of Aging at the University of Washington (NIH P30AG013280) and The Jackson Laboratory (NIH P30AG038070). M.B.L. was supported by the National Institutes of Health (NIH) Alzheimer’s Disease Training Program (T32AG052354). C.M.H. was supported by Pennington Biomedical NORC-Nutrition and Metabolic Health Through the Lifespan (NIH P30DK072476).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matt Kaeberlein.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bitto, A., Lee, M.B., Hill, C.M. et al. The AGE Presents Introduction to Geroscience video lecture series. GeroScience 43, 1697–1701 (2021). https://doi.org/10.1007/s11357-021-00403-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11357-021-00403-4

Keywords

Navigation