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Obesity and related consequences to ageing

AGE volume 38, Article number: 23 (2016) Cite this article

Abstract

Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.

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Acknowledgments

Support was provided by a grant to LPK from the Foundation for Polish Science, program WELCOME, no. WELCOME/2010-4/3 entitled “Nutrition and ambient temperature during early development can reduce susceptibility to obesity” financed by EU Structural Funds in Poland within the Innovative Economy Program and REFRESH project (FP7-REGPOT-2010-1-264103).

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  1. Institute of Animal Reproduction and Food Research, Polish Academy of Science, ul. Tuwima 10, 10-748, Olsztyn, Poland

    Magdalena Jura & Leslie.P. Kozak

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  1. Magdalena Jura
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  2. Leslie.P. Kozak
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Correspondence to Leslie.P. Kozak.

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Jura, M., Kozak, L. Obesity and related consequences to ageing. AGE 38, 23 (2016). https://doi.org/10.1007/s11357-016-9884-3

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Keywords

  • Metabolic syndrome
  • Lean mass
  • Brown adipose tissue
  • Expandability