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AGE

, 37:38 | Cite as

Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial

  • H. MacphersonEmail author
  • R. Rowsell
  • K. H. M. Cox
  • A. Scholey
  • A. Pipingas
Article

Abstract

A number of randomised controlled trials have indicated that multivitamin/mineral supplementation for a period of 4 weeks or greater can enhance mood and cognition. To date, no studies have investigated whether a single multivitamin dose can benefit mental function in older adults. This study investigated the acute effects of a single multivitamin and mineral and herbal (MVMH) supplement versus placebo on self ratings of mood and the performance of an effortful computerised cognitive battery in a sample of 76 healthy women aged 50–75 years. Mood was assessed using the depression anxiety stress scale (DASS), state trait anxiety inventory–state anxiety scale and visual analogue scales (VAS). Mood was rated at 1 h post supplementation and again after the competition of the cognitive assessments at 2 h post supplementation. It was demonstrated that the MVMH supplement improved overall DASS mood ratings; however, the most prominent effects appeared to be a reduction in ratings of perceived mental stress. These findings were confirmed using visual analogue scales, with these measures also demonstrating MVMH-related increased ratings of calmness. There were no benefits of the MVMH to mood ratings of depression and performance was not enhanced on the cognitive battery. Supplementation with a single multivitamin, mineral and herbal supplement reduces stress several hours after intake in healthy older people.

Keywords

Multivitamin Multivitamin/mineral Mood Cognition Stress Elderly 

References

  1. Alpert JE, Mischoulon D, Nierenberg AA, Fava M (2000) Nutrition and depression: focus on folate. Nutrition 16:544–546PubMedCrossRefGoogle Scholar
  2. Baldewicz TT, Goodkin K, Blaney NT, Shor-Posner G, Kumar M, Wilkie FL, Baum MK, Eisdorfer C (2000) Cobalamin level is related to self-reported and clinically rated mood and to syndromal depression in bereaved HIV-1+ and HIV-1- homosexual men. J Psychosom Res 48:177–185PubMedCrossRefGoogle Scholar
  3. Benton D (2002) Selenium intake, mood and other aspects of psychological functioning. Nutr Neurosci 5:363–374PubMedCrossRefGoogle Scholar
  4. Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Psychol 47:211–218CrossRefGoogle Scholar
  5. Bottiglieri T (2005) Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 29:1103–1112PubMedCrossRefGoogle Scholar
  6. Brownie S (2006) Why are elderly individuals at risk of nutritional deficiency? Int J Nurs Pract 12:110–118PubMedCrossRefGoogle Scholar
  7. Carroll D, Ring C, Suter M, Willemsen G (2000) The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology 150:220–225PubMedCrossRefGoogle Scholar
  8. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12:189–198CrossRefGoogle Scholar
  9. Grima NA, Pase MP, Macpherson H, Pipingas A (2012) The effects of multivitamins on cognitive performance: a systematic review and meta-analysis. J Alzheimers Dis 29:561–569PubMedGoogle Scholar
  10. Harris E, Kirk J, Rowsell R, Vitetta L, Sali A, Scholey AB, Pipingas A (2011) The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol 26:560–567PubMedCrossRefGoogle Scholar
  11. Harris E, Kirk J, Vitetta L, Macpherson H, Sali A, Pipingas A (2012) Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in a group of older males: a randomised, placebo controlled trial. Hum Psychopharmacol 27:370–377PubMedCrossRefGoogle Scholar
  12. Haskell CF, Scholey AB, Jackson PA, Elliott JM, Defeyter MA, Greer J, Robertson BC, Buchanan T, Tiplady B, Kennedy DO (2008) Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals. Br J Nutr 100:1086–1096PubMedCrossRefGoogle Scholar
  13. Haskell CF, Robertson B, Jones E, Forster J, Jones R, Wilde A, Maggini S, Kennedy DO (2010) Effects of a multi-vitamin/mineral supplement on cognitive function and fatigue during extended multi-tasking. Hum Psychopharmacol 25:448–461PubMedCrossRefGoogle Scholar
  14. Huskisson E, Maggini S, Ruf M (2007) The influence of micronutrients on cognitive function and performance. J Int Med Res 35:1–19PubMedCrossRefGoogle Scholar
  15. Kaplan BJ, Crawford SG, Field CJ, Simpson JSA (2007) Vitamins, minerals, and mood. Psychol Bull 133:747–760PubMedCrossRefGoogle Scholar
  16. Kemeny ME (2003) The psychobiology of stress. Curr Dir Psychol Sci 12:124–129CrossRefGoogle Scholar
  17. Kennedy DO, Haskell CF, Robertson B, Reay J, Brewster-Maund C, Luedemann J, Maggini S, Ruf M, Zangara A, Scholey AB (2008) Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guarana (Paullinia cupana). Appetite 50:506–513PubMedCrossRefGoogle Scholar
  18. Kennedy DO, Veasey R, Watson A, Dodd F, Jones E, Maggini S, Haskell CF (2010) Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology 211:1–14CrossRefGoogle Scholar
  19. Levenson CW (2006) Zinc: the new antidepressant? Nutr Rev 64:39–42PubMedCrossRefGoogle Scholar
  20. Long SJ, Benton D (2013) Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosomatic Med 75:144–153CrossRefGoogle Scholar
  21. Lovibond SH LP (1995) Manual for the Depression Anxiety Stress Scales. In: Foundation P (ed), Sydney, AustraliaGoogle Scholar
  22. Lovibond SH, Lovibond PF (1995) Manual for the Depression Anxiety Stress Scales. Psychology Foundation, Sydney, AustraliaGoogle Scholar
  23. Macpherson H, Ellis KA, Sali A, Pipingas A (2012) Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement—a randomised controlled trial. Psychopharmacology 220:351–365PubMedCrossRefGoogle Scholar
  24. Maki KC, Ndife LI, Kelley KM, Lawless AL, Brooks JR, Wright SB, Shields JM, Dicklin MR (2012) Absorption of folic acid from a softgel capsule compared to a standard tablet. J Acad Nutr Diet 112:1062–1067PubMedCrossRefGoogle Scholar
  25. Malouf R, Grimley Evans J, Areosa Sastre A (2003) Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database of Systematic ReviewsGoogle Scholar
  26. Nelson HE, Willison J (1991) National Adult Reading Test (NART) test manual, Second Edition ednGoogle Scholar
  27. Pipingas A, Camfield DA, Stough C, Cox KH, Fogg E, Tiplady B, Sarris J, White DJ, Sali A, Wetherell MA, Scholey AB (2013) The effects of multivitamin supplementation on mood and general well-being in healthy young adults. A laboratory and at-home mobile phone assessment. Appetite 69:123–136PubMedCrossRefGoogle Scholar
  28. Pipingas A, Camfield DA, Stough C, Scholey AB, Cox KHM, White D, Sarris J, Sali A, Macpherson H (2014) Effects of multivitamin, mineral and herbal supplement on cognition in younger adults and the contribution of B group vitamins. Hum Psychopharmacol 29:73–82PubMedCrossRefGoogle Scholar
  29. Schlebusch L, Bosch BA, Polglase G, Kleinschmidt I, Pillay BJ, Cassimjee MH (2000) A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J 90:1216–1223PubMedGoogle Scholar
  30. Scholey A, Harper S, Kennedy DO (2001) Cognitive demand and blood glucose. Physiol Behav 73:585–592PubMedCrossRefGoogle Scholar
  31. Scholey A, Bauer I, Neale C, Savage K, Camfield D, White D, Maggini S, Pipingas A, Stough C, Hughes M (2013) Acute effects of different multivitamin mineral preparations with and without guaraná on mood, cognitive performance and functional brain activation. Nutrients 5:3589–3604PubMedCentralPubMedCrossRefGoogle Scholar
  32. Speilberger CD, Gorsuch RL, Lushene RE (1969) STAI. Manual for the state-trait anxiety inventory. Consulting Psychologists Press, Palo AltoGoogle Scholar
  33. Stough C, Scholey A, Lloyd J, Spong J, Myers S, Downey LA (2011) The effect of 90 day administration of a high dose vitamin B-complex on work stress. Hum Psychopharmacol 26:470–476PubMedCrossRefGoogle Scholar
  34. Summers WK, Martin RL, Cunningham M, Deboynton VL, Marsh GM (2010) Complex antioxidant blend improves memory in community-dwelling seniors. J Alzheimer's Dis 19:429–439Google Scholar
  35. Tolmunen T, Voutilainen S, Hintikka J, Rissanen T, Tanskanen A, Viinamaki H, Kaplan GA, Salonen JT (2003) Dietary folate and depressive symptoms are associated in middle-aged Finnish men. J Nutr 133:3233–3236PubMedGoogle Scholar
  36. White DJ, Camfield DA, Maggini S, Pipingas A, Silberstein R, Stough C, Scholey A (2014) The effect of a single dose of multivitamin and mineral combinations with and without guarana on functional brain activity during a continuous performance task. Nutr NeurosciGoogle Scholar
  37. Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC (2006) Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatric Psychiatry 14:1032–1040CrossRefGoogle Scholar

Copyright information

© American Aging Association 2015

Authors and Affiliations

  • H. Macpherson
    • 1
    • 2
    Email author
  • R. Rowsell
    • 1
  • K. H. M. Cox
    • 1
  • A. Scholey
    • 1
  • A. Pipingas
    • 1
  1. 1.Centre for Human PsychopharmacologySwinburne UniversityMelbourneAustralia
  2. 2.Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Faculty of HealthDeakin UniversityBurwoodAustralia

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