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ACE polymorphism and use of ACE inhibitors: effects on memory performance

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Abstract

Memory is an important cognition function, being fundamental to the development and independence of individuals. Our aim was to investigate the influence apolipoprotein E (APOE) and angiotensin I-converting enzyme (ACE) polymorphism and ACE inhibitors use, besides their interaction on memory performance of healthy subjects over 50 years. The sample consisted of 205 subjects assessed for five types of episodic memory, using Wechsler Memory Scale-Revised (WMS-R), who answered a questionnaire about drug use and were assessed for the ACE insertion/deletion polymorphism and APOE polymorphism. We found no influence of the APOE gene. The use of ACE inhibitors beneficially influenced learning ability scores (p = 0.02). Besides, I allele carriers of ACE polymorphism showed higher verbal memory scores compared with homozygous DD. Also, we observed an interaction influencing learning ability between the ACE polymorphism and the use of inhibitors, the beneficial influence of the I allele was present only in individuals who make use of ACE inhibitors. We conclude that the ACE gene has influence on memory performance, and that this influence is modulated by ACE inhibitors use.

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Authors and Affiliations

  1. Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil

    Jaqueline B. Schuch, Pamela C. Constantin, Vanessa K. da Silva, Camila Korb & Fabiana M. de Andrade

  2. Institute of Human Sciences, Letters and Arts, Universidade Feevale, Novo Hamburgo, RS, Brazil

    Daiani P. Bamberg, Luciana A. Tisser & Fabiana M. de Andrade

  3. Basic Health Sciences Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Tatiane J. da Rocha & Marilu Fiegenbaum

  4. Psychology Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Alcyr de Oliveira Jr

  5. Pró-Reitoria de Pesquisa e Inovação – PROPI, sala 201 F, Universidade Feevale, RS 239, no. 2755, Novo Hamburgo, RS, 93352-000, Brazil

    Fabiana M. de Andrade

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  1. Jaqueline B. Schuch
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  2. Pamela C. Constantin
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Correspondence to Fabiana M. de Andrade.

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Schuch, J.B., Constantin, P.C., da Silva, V.K. et al. ACE polymorphism and use of ACE inhibitors: effects on memory performance. AGE 36, 1515–1522 (2014). https://doi.org/10.1007/s11357-014-9646-z

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  • DOI: https://doi.org/10.1007/s11357-014-9646-z

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