, Volume 35, Issue 6, pp 2111–2124 | Cite as

Age-related neural correlates of cognitive task performance under increased postural load

  • A. Van ImpeEmail author
  • S. M. Bruijn
  • J. P. Coxon
  • N. Wenderoth
  • S. Sunaert
  • J. Duysens
  • S. P. Swinnen


Behavioral studies suggest that postural control requires increased cognitive control and visuospatial processing with aging. Consequently, performance can decline when concurrently performing a postural and a demanding cognitive task. We aimed to identify the neural substrate underlying this effect. A demanding cognitive task, requiring visuospatial transformations, was performed with varying postural loads. More specifically, old and young subjects performed mental rotations of abstract figures in a seated position and when standing on a force platform. Additionally, functional magnetic resonance imaging (fMRI) was used to identify brain regions associated with mental rotation performance. Old as compared to young subjects showed increased blood oxygenation level-dependent (BOLD) responses in a frontoparietal network as well as activations in additional areas. Despite this overall increased activation, they could still modulate BOLD responses with increasing task complexity. Importantly, activity in left lingual gyrus was highly predictive (r = −0.83, adjusted R 2 = 0.65) of the older subjects' degree of success in mental rotation performance when shifting from a sitting to a standing position. More specifically, increased activation in this area was associated with better performance, once postural load increased.


Aging Postural control Mental rotation Dual-tasking fMRI 



Support for this work was provided through a grant from the Research Fund of the Katholieke Universiteit Leuven, Belgium (OT/71/11) and the Research Foundation-Flanders (G.0721.12). Van Impe A. is funded by a Ph.D. fellowship of the Research Foundation-Flanders. Coxon J.P. is funded by a postdoctoral fellowship of the Research Foundation-Flanders (1224010 N). Bruijn S.M. is funded by a visiting postdoctoral fellowship of the Research Foundation-Flanders (GP.030.10.N).

Supplementary material

11357_2012_9499_MOESM1_ESM.doc (27 kb)
ESM 1 (DOC 27 kb)


  1. Andersson G, Yardley L, Luxon L (1998) A dual-task study of interference between mental activity and control of balance. Am J Otol 19:632–637PubMedGoogle Scholar
  2. Andersson G, Hagman J, Talianzadeh R, Svedberg A, Larsen HC (2002) Effect of cognitive load on postural control. Brain Res Bull 58:135–139PubMedGoogle Scholar
  3. Baltes PB, Baltes MM (1990) Psychological perspectives on successful aging: the model of selective optimization with compensation. In: Baltes MM, Baltes PB (eds) Successful aging: perspectives from the behavioral science. Cambridge University Press, New York, pp 1–34Google Scholar
  4. Beckmann CF, Jenkinson M, Smith SM (2003) General multilevel linear modeling for group analysis in FMRI. NeuroImage 20:1052–1063PubMedGoogle Scholar
  5. Bonda E, Frey S, Petrides M (1996) Evidence for a dorso-medial parietal system involved in mental transformations of the body. J Neurophysiol 76:2042–2048PubMedGoogle Scholar
  6. Brown LA, Sleik RJ, Polych MA, Gage WH (2002) Is the prioritization of postural control altered in conditions of postural threat in younger and older adults? J Gerontol A Biol Sci Med Sci 57:M785–M792PubMedGoogle Scholar
  7. Burgess PW, Quayle A, Frith CD (2001) Brain regions involved in prospective memory as determined by positron emission tomography. Neuropsychologia 39:545–555PubMedGoogle Scholar
  8. Cabeza R (2002) Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging 17:85–100PubMedGoogle Scholar
  9. Cabeza R, Anderson ND, Locantore JK, McIntosh AR (2002) Aging gracefully: compensatory brain activity in high-performing older adults. NeuroImage 17:1394–1402PubMedGoogle Scholar
  10. Cerella J, Poon LW, Fozard JL (1981) Mental rotation and age reconsidered. J Gerontol 36:620–624PubMedGoogle Scholar
  11. Cohen MS, Kosslyn SM, Breiter HC, Di Girolamo GJ, Thompson WL, Anderson AK, Brookheimer SY, Rosen BR, Belliveau JW (1996) Changes in cortical activity during mental rotation: a mapping study using functional MRI. Brain 119:89–100PubMedGoogle Scholar
  12. Corballis MC (1997) Mental rotation and the right hemisphere. Brain Lang 57:100–121PubMedGoogle Scholar
  13. Cornette L, Dupont P, Rosier A, Sunaert S, Van Hecke P, Michiels J, Mortelmans L, Orban GA (1998) Human brain regions involved in direction discrimination. J Neurophysiol 79:2749–2765PubMedGoogle Scholar
  14. Dault MC, Geurts AC, Mulder TW, Duysens J (2001) Postural control and cognitive task performance in healthy participants while balancing on different support-surface configurations. Gait Posture 14:248–255PubMedGoogle Scholar
  15. de Lange FP, Hagoort P, Toni I (2005) Neural topography and content of movement representations. J Cogn Neurosci 17:97–112PubMedGoogle Scholar
  16. Doumas M, Smolders C, Krampe RT (2008) Task prioritization in aging: effects of sensory information on concurrent posture and memory performance. Exp Brain Res 187:275–281PubMedGoogle Scholar
  17. Doumas M, Rapp MA, Krampe RT (2009) Working memory and postural control: adult age differences in potential for improvement task priority and dual tasking. J Gerontol B Psychol Sci Soc Sci 64:193–201PubMedGoogle Scholar
  18. Gaylord SA, Marsh GR (1975) Age differences in the speed of a spatial cognitive process. J Gerontol 30:674–678PubMedGoogle Scholar
  19. Goble DJ, Coxon JP, Van Impe A, De Vos J, Wenderoth N, Swinnen SP (2010) The neural control of bimanual movements in the elderly: brain regions exhibiting age-related increases in activity frequency-induced neural modulation and task-specific compensatory recruitment. Hum Brain Mapp 31:1281–1295PubMedGoogle Scholar
  20. Gogos A, Gavrilescu M, Davison S, Searle K, Adams J, Rossell SL, Bell R, Davis SR, Egan GF (2010) Greater superior than inferior parietal lobule activation with increasing rotation angle during mental rotation: an fMRI study. Neuropsychologia 48:529–535PubMedGoogle Scholar
  21. Grady CL, Yu H, Alain C (2008) Age-related differences in brain activity underlying working memory for spatial and nonspatial auditory information. Cereb Cortex 18:189–199PubMedGoogle Scholar
  22. Gutchess AH, Welsh RC, Hedden T, Bangert A, Minear M, Liu LL, Park DC (2005) Aging and the neural correlates of successful picture encoding: frontal activations compensate for decreased medial-temporal activity. J Cogn Neurosci 17:84–96PubMedGoogle Scholar
  23. Hanes DA, McCollum G (2006) Cognitive–vestibular interactions: a review of patient difficulties and possible mechanisms. J Vestib Res 16:75–91PubMedGoogle Scholar
  24. Harris IM, Egan GF, Sonkkila C, Tochon-Danguy HJ, Paxinos G, Watson JD (2000) Selective right parietal lobe activation during mental rotation: a parametric PET study. Brain 123:65–73PubMedGoogle Scholar
  25. Harris IM, Harris JA, Caine D (2002) Mental-rotation deficits following damage to the right basal ganglia. Neuropsychology 16:524–537PubMedGoogle Scholar
  26. Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI (1991) Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc Natl Acad Sci USA 88:1621–1625PubMedGoogle Scholar
  27. Hedden T, Van Dijk KR, Shire EH, Sperling RA, Johnson KA, Buckner RL (2011) Failure to modulate attentional control in advanced aging linked to white matter pathology. Cereb Cortex 22:1038–1051PubMedGoogle Scholar
  28. Hertzog C, Vernon MC, Rypma B (1993) Age differences in mental rotation task performance: the influence of speed/accuracy tradeoffs. J Gerontol 48:150–156Google Scholar
  29. Heuninckx S, Wenderoth N, Debaere F, Peeters R, Swinnen SP (2005) Neural basis of aging: the penetration of cognition into action control. J Neurosci 25:6787–6796PubMedGoogle Scholar
  30. Heuninckx S, Wenderoth N, Swinnen SP (2008) Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons. J Neurosci 28:91–99PubMedGoogle Scholar
  31. Huxhold O, Li SC, Schmiedek F, Lindenberger U (2006) Dual-tasking postural control: aging and the effects of cognitive demand in conjunction with focus of attention. Brain Res Bull 69:294–305PubMedGoogle Scholar
  32. Jahn K, Deutschlander A, Stephan T, Strupp M, Wiesmann M, Brandt T (2004) Brain activation patterns during imagined stance and locomotion in functional magnetic resonance imaging. NeuroImage 22:1722–1731PubMedGoogle Scholar
  33. Jeka JJ, Allison LK, Kiemel T (2010) The dynamics of visual reweighting in healthy and fall-prone older adults. J Mot Behav 42:197–208PubMedGoogle Scholar
  34. Kerr B, Condon SM, McDonald LA (1985) Cognitive spatial processing and the regulation of posture. J Exp Psychol Hum Percept Perform 11:617–622PubMedGoogle Scholar
  35. Kosslyn SM, Thompson WL, Wraga M, Alpert NM (2001) Imagining rotation by endogenous versus exogenous forces: distinct neural mechanisms. Neuroreport 12:2519–2525PubMedGoogle Scholar
  36. Lacour M, Bernard-Demanze L, Dumitrescu M (2008) Posture control aging and attention resources: models and posture-analysis methods. Neurophysiol Clin 38:411–421PubMedGoogle Scholar
  37. Lajoie Y, Teasdale N, Bard C, Fleury M (1993) Attentional demands for static and dynamic equilibrium. Exp Brain Res 97:139–144PubMedGoogle Scholar
  38. Lamm C, Windischberger C, Moser E, Bauer H (2007) The functional role of dorso-lateral premotor cortex during mental rotation: an event-related fMRI study separating cognitive processing steps using a novel task paradigm. NeuroImage 36:1374–1386PubMedGoogle Scholar
  39. Madden DJ, Spaniol J, Whiting WL, Bucur B, Provenzale JM, Cabeza R, White LE, Huettel SA (2007) Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study. Neurobiol Aging 28:459–476PubMedGoogle Scholar
  40. Mast FW, Merfeld DM, Kosslyn SM (2006) Visual mental imagery during caloric vestibular stimulation. Neuropsychologia 44:101–109PubMedGoogle Scholar
  41. Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113Google Scholar
  42. Osterrieth P (1944) Le teste de copie d'une figure complex: contribution à l'étude de la perception et de la memoire. Arch Psychol 30:206–356Google Scholar
  43. Peiffer AM, Hugenschmidt CE, Maldjian JA, Casanova R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ (2009) Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp 30:228–240PubMedGoogle Scholar
  44. Perennou D (2006) Postural disorders and spatial neglect in stroke patients: a strong association. Restor Neurol Neurosci 24:319–334PubMedGoogle Scholar
  45. Peruch P, Lopez C, Redon-Zouiteni C, Escoffier G, Zeitoun A, Sanjuan M, Deveze A, Magnan J, Borel L (2011) Vestibular information is necessary for maintaining metric properties of representational space: evidence from mental imagery. Neuropsychologia 49:3136–3144PubMedGoogle Scholar
  46. Picard N, Strick PL (2001) Imaging the premotor areas. Curr Opin Neurobiol 11:663–672PubMedGoogle Scholar
  47. Ramnani N, Owen AM (2004) Anterior prefrontal cortex: insights into function from anatomy and neuroimaging. Nat Rev Neuosci 5:184–194Google Scholar
  48. Redfern MS, Jennings JR, Martin C, Furman JM (2001) Attention influences sensory integration for postural control in older adults. Gait Posture 14:211–216PubMedGoogle Scholar
  49. Ronsse R, Puttemans V, Coxon JP, Goble DJ, Wagemans J, Wenderoth N, Swinnen SP (2010) Motor learning with augmented feedback: modality-dependent behavioral and neural consequences. Cereb Cortex 21:1283–1294PubMedGoogle Scholar
  50. Rosen AC, Prull MW, O'Hara R, Race EA, Desmond JE, Glover GH, Yesavage JA, Gabrieli JD (2002) Variable effects of aging on frontal lobe contributions to memory. Neuroreport 13:2425–2428PubMedGoogle Scholar
  51. Rosen AC, Gabrieli JD, Stoub T, Prull MW, O'Hara R, Yesavage J, Toledo-Morrell L (2005) Relating medial temporal lobe volume to frontal fMRI activation for memory encoding in older adults. Cortex 41:595–602PubMedGoogle Scholar
  52. Rottschy C, Eickhoff SB, Schleicher A, Mohlberg H, Kujovic M, Zilles K, Amunts K (2007) Ventral visual cortex in humans: cytoarchitectonic mapping of two extrastriate areas. Hum Brain Mapp 28:1045–1059PubMedGoogle Scholar
  53. Seurinck R, Vingerhoets G, de Lange FP, Achten E (2004) Does egocentric mental rotation elicit sex differences? NeuroImage 23:1440–1449PubMedGoogle Scholar
  54. Shepard RN, Metzler J (1971) Mental rotation of three-dimensional objects. Science 171:701–703PubMedGoogle Scholar
  55. Shumway-Cook A, Woollacott M, Kerns KA, Baldwin M (1997) The effects of two types of cognitive tasks on postural stability in older adults with and without a history of falls. J Gerontol A Biol Sci Med Sci 52:M232–M240PubMedGoogle Scholar
  56. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23(Suppl 1):S208–S219PubMedGoogle Scholar
  57. Sturnieks DL, St George R, Fitzpatrick RC, Lord SR (2008) Effects of spatial and nonspatial memory tasks on choice stepping reaction time in older people. J Gerontol A Biol Sci Med Sci 63:1063–1068PubMedGoogle Scholar
  58. Swan L, Otani H, Loubert PV, Sheffert SM, Dunbar GL (2004) Improving balance by performing a secondary cognitive task. Br J Psychol 95:31–40PubMedGoogle Scholar
  59. Tombu M, Jolicoeur P (2003) A central capacity sharing model of dual-task performance. J Exp Psychol Hum Percept Perform 29:3–18PubMedGoogle Scholar
  60. VanderVelde TJ, Woollacott MH, Shumway-Cook A (2005) Selective utilization of spatial working memory resources during stance posture. Neuroreport 16:773–777PubMedGoogle Scholar
  61. Vingerhoets G, de Lange FP, Vandemaele P, Deblaere K, Achten E (2002) Motor imagery in mental rotation: an fMRI study. NeuroImage 17:1623–1633PubMedGoogle Scholar
  62. Vuillerme N, Nougier V, Teasdale N (2000) Effects of a reaction time task on postural control in humans. Neurosci Lett 291:77–80PubMedGoogle Scholar
  63. Ward NS, Swayne OB, Newton JM (2008) Age-dependent changes in the neural correlates of force modulation: an fMRI study. Neurobiol Aging 29:1434–1446PubMedGoogle Scholar
  64. Wexler M, Kosslyn SM, Berthoz A (1998) Motor processes in mental rotation. Cognition 68:77–94PubMedGoogle Scholar
  65. Wohlschlager A (2001) Mental object rotation and the planning of hand movements. Percept Psychophys 63:709–718PubMedGoogle Scholar
  66. Wohlschlager A, Wohlschlager A (1998) Mental and manual rotation. J Exp Psychol Hum Percept Perform 24:397–412PubMedGoogle Scholar
  67. Woollacott M, Shumway-Cook A (2002) Attention and the control of posture and gait: a review of an emerging area of research. Gait Posture 16:1–14PubMedGoogle Scholar
  68. Woollacott M, Vander Velde T (2008) Non-visual spatial tasks reveal increased interactions with stance postural control. Brain Res 1208:95–102PubMedGoogle Scholar
  69. Wraga M, Thompson WL, Alpert NM, Kosslyn SM (2003) Implicit transfer of motor strategies in mental rotation. Brain Cogn 52:135–143PubMedGoogle Scholar
  70. Zacks JM (2008) Neuroimaging studies of mental rotation: a meta-analysis and review. J Cogn Neurosci 20:1–19PubMedGoogle Scholar
  71. Zwergal A, Linn J, Xiong G, Brandt T, Strupp M, Jahn K (2012) Aging of human supraspinal locomotor and postural control in fMRI. Neurobiol Aging 33:1073–1084PubMedGoogle Scholar

Copyright information

© American Aging Association 2012

Authors and Affiliations

  • A. Van Impe
    • 1
    • 6
    Email author
  • S. M. Bruijn
    • 1
  • J. P. Coxon
    • 1
  • N. Wenderoth
    • 1
  • S. Sunaert
    • 2
  • J. Duysens
    • 1
    • 3
  • S. P. Swinnen
    • 1
    • 4
    • 5
  1. 1.Research Center for Movement Control and Neuroplasticity, K.U. LeuvenLeuvenBelgium
  2. 2.Department of RadiologyUniversity Hospital, K.U. LeuvenLeuvenBelgium
  3. 3.Department of Research, Development and EducationSint-MaartenskliniekNijmegenThe Netherlands
  4. 4.Movement Control and Neuroplasticity Research Group, Group Biomedical SciencesHeverleeBelgium
  5. 5.Leuven Research Institute for Neuroscience & Disease O&N4LeuvenBelgium
  6. 6.Movement Control and Neuroplasticity Research GroupGroup Biomedical SciencesHeverleeBelgium

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