Table 2 Identification of plasma metabolites at baseline and at 3-year follow-up

l-Valine

C₅H₁₁NO₂

118.0789

−6.0

13.0 ± 0.45

15.3 ± 0.53

1.140

0.001

0.2058

Pyrroline hydroxycarboxylic acid

C₅H₇NO₃

130.0425

−6.4

3.30 ± 0.10

2.54 ± 0.10

0.737

<0.001

0.2809

l − Tryptophan

C₁₁H₁₂N₂O₂

205.0898

−7.6

32.1 ± 1.56

31.4 ± 1.64

0.944

0.704

0.8036

Linoleyl carnitine

C₂₅H₄₅NO₄

424.3348

−4.4

25.6 ± 1.09

21.9 ± 1.29

0.845

0.009

1.4369

LysoPC (16:0)

C₂₄H₅₀NO₇P

496.3324

−6.0

718.7 ± 16.2

778.1 ± 27.1

1.064

0.028

6.2029

LysoPC (18:0)

C₂₆H₅₄NO₇P

524.3637

−6.2

545.9 ± 15.0

574.0 ± 17.0

1.043

0.231

4.6709

LysoPC (18:2)

C₂₆H₅₀NO₇P

520.3325

−5.9

467.8 ± 11.4

510.6 ± 14.4

1.081

0.004

4.6890

LysoPC (18:3)

C₂₆H₄₈NO₇P

518.3168

−6.2

12.5 ± 0.66

14.8 ± 0.98

1.152

0.068

0.4923

LysoPC (20:4)

C₂₈H₅₀NO₇P

544.3325

2.5

54.7 ± 3.56

66.1 ± 6.38

1.175

0.021

1.4186

LysoPC (20:5)

C₂₈H₄₈NO₇P

542.3168

−0.7

39.1 ± 1.52

45.4 ± 1.32

1.134

0.002

1.1194

LysoPC (22:5)

C₃₀H₅₂NO₇P

570.3481

−8.3

1.88 ± 0.18

2.56 ± 0.22

1.272

0.002

0.0565

LysoPC (22:6)

C₃₀H₅₀NO₇P

568.3325

3.6

48.3 ± 1.36

53.0 ± 1.16

1.083

0.007

0.5201

LysoPE (18:0)

C₂₃H₄₈NO₇P

482.3168

−7.4

8.88 ± 0.50

10.7 ± 0.43

1.176

0.004

0.2748

LysoPE (22:6)

C₂₇H₄₄NO₇P

526.2855

−5.8

28.1 ± 0.77

31.5 ± 0.98

1.107

0.003

0.5602

Total LysoPC

–

–

–

8.59 ± 1.23

6.51 ± 0.83

0.713

0.001

–

Unknown 1

–

417.3290

−7.3

–

–

0.100

–

0.5015

Unknown 2

–

585.2634

−8.5

–

-

1.720

-

0.5597