, Volume 30, Issue 4, pp 187–199 | Cite as

Design of aging intervention studies: the NIA interventions testing program

  • N. L. NadonEmail author
  • R. Strong
  • R. A. Miller
  • J. Nelson
  • M. Javors
  • Z. D. Sharp
  • J. M. Peralba
  • D. E. Harrison


The field of biogerontology has made great strides towards understanding the biological processes underlying aging, and the time is ripe to look towards applying this knowledge to the pursuit of aging interventions. Identification of safe, inexpensive, and non-invasive interventions that slow the aging process and promote healthy aging could have a significant impact on quality of life and health care expenditures for the aged. While there is a plethora of supplements and interventions on the market that purport to slow aging, the evidence to validate such claims is generally lacking. Here we describe the development of an aging interventions testing program funded by the National Institute on Aging (NIA) to test candidate interventions in a model system. The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program.


Anti-aging Lifespan Longevity Mice 



This work was support by grants from the National Institutes of Health U01-AG-022307 (R.S.), U01-AG-022303 (R.A.M.) and U01-AG-022308 (D.E.H.).


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Copyright information

© American Aging Association, Media, PA, USA 2008

Authors and Affiliations

  • N. L. Nadon
    • 1
    Email author
  • R. Strong
    • 2
    • 4
    • 9
  • R. A. Miller
    • 5
  • J. Nelson
    • 3
    • 4
  • M. Javors
    • 6
  • Z. D. Sharp
    • 7
  • J. M. Peralba
    • 7
  • D. E. Harrison
    • 8
  1. 1.Biology of Aging ProgramNational Institute on AgingBethesdaUSA
  2. 2.Department of PharmacologyUniversity of Texas Health Sciences CenterSan AntonioUSA
  3. 3.Department of PhysiologyUniversity of Texas Health Sciences CenterSan AntonioUSA
  4. 4.Barshop Aging InstituteUniversity of Texas Health Sciences CenterSan AntonioUSA
  5. 5.Department of Pathology and Geriatrics CenterUniversity of Michigan and VA Medical CenterAnn ArborUSA
  6. 6.Department of PsychiatryUniversity of Texas Health Sciences CenterSan AntonioUSA
  7. 7.Department of Molecular MedicineUniversity of Texas Health Sciences CenterSan AntonioUSA
  8. 8.Jackson LaboratoriesBar HarborUSA
  9. 9.South Texas Veterans Health Care SystemSan AntonioUSA

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