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Avian immunosenescence

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Abstract

Immunosenescence, the aging of the immune system, is well studied in humans. Mammalian immune systems become less capable of fighting pathogens and individuals become more susceptible to infection and cancer in their elder years. Little is currently published on avian immunosenescence even though avian immune function has been well characterized and birds have been critical models in the study of immunology. The value of birds in the study of aging has been well established. Evidence demonstrates a decline in cell-mediated and (or) humoral immune function with age in four species: the barn swallow, collared flycatcher, ruff and Japanese quail. These studies suggest that birds may experience age-related changes in immune function similar to humans. Therefore, avian aging models should be evaluated for changes in immune function and comparisons made between short- and long-lived birds. Specifically, data on age-related changes in innate immunity are lacking for birds and should be characterized. These data will strengthen the use of avian models for the study of aging.

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References

  • Apanius V and Nesbit ICT (2003) Serum immunoglobulin G levels in very old common terns Sterna hirundo. Exp Gerontol 38(7): 761–764

    Article  CAS  PubMed  Google Scholar 

  • Balthazart J and Adkins-Regan E (2002) Sexual differentiation of brain and behavior in birds. In: Pfaff D (ed) Hormones, Brain and Behavior, Vol. 4, p 881. Academic, San Diego CA

    Google Scholar 

  • Chen CH and Six A et al. (1996) T Cell Receptors and T Cell Development. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Cichón M and Sendecka J et al. (2003) Age-related decline in humoral immune function in collared flycatchers. J Evol Biol 16(6): 1205–1210

    PubMed  Google Scholar 

  • Fairbrother A, Smits J and Grasman KA (2004) Avian immunotoxicology. J Toxicol Environ Health, B 7: 105–137

    CAS  Google Scholar 

  • Funk PE and Thompson CB (1996) Current concepts in chicken B cell development. Immunology and developmental biology of the chicken. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Glick B (1977) The bursa of Fabricius and immunoglobulin synthesis. Int Rev Cytol 48: 345–402

    CAS  PubMed  Google Scholar 

  • Glick B (2000) Immunophysiology. Sturkie's Avian Physiology. G. C. Whittow. Academic, San Diego

    Google Scholar 

  • Holmes DJ and Ottinger MA (2003) Birds as long-lived animal models for the study of aging. Exp Gerontol 38: 1365–1375

    CAS  PubMed  Google Scholar 

  • Janeway CA and Travers P (1997) Immunobiology: the immune system in health and disease. Taylor and Francis, London

    Google Scholar 

  • Lozano GA and Lank DB (2003) Seasonal trade-offs in cell-mediated immunosenescence in ruffs (Philomachus pugnax). Proc R Soc Lond, B 270: 1203–1208

    Article  Google Scholar 

  • Malaguarnera L, Ferlito L, Imbesi RM, Gulizia GS, Ki Mauro S and Maugeri D et al. (2001) Immunosenescence: a review. Arch Gerontol Geriatr 32: 1–14

    CAS  PubMed  Google Scholar 

  • McCorkle F and Glick B (1979) The effect of aging on immune competence in the chicken:antibody mediated immunity. Poultry Sci 59: 669–672

    Google Scholar 

  • Plackett T and Boehmer E et al. (2004) Aging and innate immune cells. J Leukoc Biol 76: 291–299

    Article  CAS  PubMed  Google Scholar 

  • Potter JM, O'Donnel B, Carman WF, Roberts MA and Stoll DJ (1999) Serological response to influenza vaccination and nutritional and functional status of patients of geriatric medical long term care. Age aging 28: 141–145

    Google Scholar 

  • Reynaud C-A and Weill JC (1996) Postrearrangement Diversification Processes in Gut-Associated Lymphoid Tissues. Immunology and Developmental Biology of the Chicken. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Saino N, Ambrosini R, Martinelli R and Moller AP (2002) Mate fidelity, senescence in breeding performance and reproductive trade-offs in the barn swallow. J Anim Ecol 71: 309–319

    Article  Google Scholar 

  • Saino N and Ferrari RP et al. (2003) Humoral immune response in relation to senescence, sex and sexual ornamentation in the barn swallow (Hirundo rustica). J Evol Biol 16(6): 1127–1134

    Article  CAS  PubMed  Google Scholar 

  • Sayegh CE and Rao MA et al. (1999) Avian B cell development: lessons from transgenic models. Vet Immunol Immunopathol 72: 31

    CAS  PubMed  Google Scholar 

  • Sayegh CE and Demaries SL et al. (2000) The chicken B-cell receptor complex and its role in avian B-cell development. Immunol Rev 175: 187–200

    Google Scholar 

  • Sharma JM (1991) Overview of the avian immune system. Vet Immunol Immunopathol 30: 13

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Animal and Avian Sciences, University of Maryland, Building 142, College Park, MD, 20742, USA

    Emma T. Lavoie

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  1. Emma T. Lavoie
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Correspondence to Emma T. Lavoie.

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Lavoie, E.T. Avian immunosenescence. AGE 27, 281–285 (2005). https://doi.org/10.1007/s11357-005-4561-y

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  • DOI: https://doi.org/10.1007/s11357-005-4561-y

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