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The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation

Journal of the American Aging Association volume 26, pages 55–58 (2003)Cite this article

Abstract

Age-and gender-related changes on reduced glutathione (GSH) level, glutathione peroxidase (GPx) and glutathione reductase (GR) activities in the liver of rat exposed to different dose of whole-body g-ray irradiation were determined. In addition, the effect of administration of exogenous GSH on endogenous GSH levels, GPx and GR activities was investigated. For this aim, male and female rats aged 1 and 5 moths were divided into two groups as g-ray and g-ray+GSH. Both groups were again divided into four groups as irradiated with 2, 4, 6 and 8 Gy doses. GSH level and GPx activity did not change with age while GR activity was decreased with age. Gender-dependent changes in GPx and GR activities were observed, but GSH values were not affect by sex. GSH levels, GPx and GR activities were not observed dose-associated changes of g-irradiation. GSH level and GPx activity in the 8Gy group were increased by GSH. GR activities of old male rats were found to be increased by glutathione in the 6 and 8Gy groups. These results indicate that radiation and administration of exogenous GSH affect gender-and age-dependent GSH level, GPx and GR activities in the rats.

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Affiliations

  1. Department of Biochemistry, The Medical School, Osmangazi University, Eskisehir, 26480, Turkey

    Mine Erden Inal & Asiye Akgün

  2. Department of Biochemistry, The Medical School, Kocatepe University, Afyon, 03200, Turkey

    Ahmet Kahraman

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  1. Mine Erden Inal
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  2. Asiye Akgün
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  3. Ahmet Kahraman
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Correspondence to Ahmet Kahraman.

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Erden Inal, M., Akgün, A. & Kahraman, A. The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation. AGE 26, 55–58 (2003). https://doi.org/10.1007/s11357-003-0005-8

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  • DOI: https://doi.org/10.1007/s11357-003-0005-8

Keywords

  • Glutathione
  • Glutathione Peroxidase
  • Glutathione Reductase
  • Reductase Activity
  • Reduce Glutathione