Abstract
Despite preventive legislation, the popularity and consumption of new psychoactive substances (NPS) have been steadily increasing in recent years. This study provides a rapid and sensitive method for the quantitation and the detection of 56 NPS from surface water. Sample clean-up and pre-concentration were performed by solid-phase extraction (SPE) with Oasis HLB (6 cc/500 mg) cartridge. Following the chromatographic separation with Shim-pack FC-ODS column, the all substances were quantified by liquid chromatography-tandem mass spectrometry. The method was optimized and validated for all NPS. Despite the wide variety of physicochemical properties of the analytes, the recoveries for all compounds studied were in the range of 69–117%. The limit of quantitation (LOQ) ranging from 2.5 to 15 ng/L was reached for reliable and accurate quantification of analytes. The analytical method developed was successfully applied to the surface water samples. While synthetic cannabinoids were not detected, mephedrone from the synthetic cathinone group was detected under the LOQ. This novel method was expected to be a part of future environmental routine analyses as a satisfactory method.
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The datasets generated and/or analyzed during the current study are not publicly available due to the reason why data are not public but are available from the corresponding author on reasonable request.
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Asli Atasoy-Aydin and Evsen Yavuz Guzel carried out the experiments and verified the analytical methods. Nebile Daglioglu supervised the findings of this work and developed the theory. İsmail Ethem Gören wrote the manuscript with support from Nebile Daglioglu and helped in providing revision of the manuscript.
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Atasoy Aydin, A., Gören, İ.E., Yavuz Guzel, E. et al. Method development, validation, and application for simultaneous determination of 56 new psychoactive substances in surface water by LC-MS/MS. Environ Sci Pollut Res 30, 85920–85929 (2023). https://doi.org/10.1007/s11356-023-28495-9
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DOI: https://doi.org/10.1007/s11356-023-28495-9