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Long-term exposure to air pollution and anti-mullerian hormone rate of decline: a population-based cohort study in Tehran, Iran

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Abstract

Anti-mullerian hormone (AMH) concentration is a marker of ovarian reserve that decreases with age. However, a decrease in AMH may occur more rapidly under the influence of environmental factors. The present study investigated the association between long-term exposure to ambient air pollutants with serum concentrations of AMH and the AMH rate of decline. This study included 806 women with median age of 43 years (interquartile range: 38–48) participating in the Tehran Lipid and Glucose Study (TLGS) that were followed from 2005 to 2017. The AMH concentration and the demographic, anthropometric, and personal health parameters of the study participants were obtained from the TLGS cohort database. Air pollutant data were collected from the monitoring stations and the individual exposures were estimated by previously developed land use regression (LUR) models. Multiple linear regression analysis was used to estimate linear relationships between the air pollutant exposures and serum concentration of AMH and with the AMH declination rate. The results show no statistically significant associations between exposures to any of the air pollutants (including PM10, PM2.5, SO2, NO, NO2, NOX, and benzene, toluene, ethylbenzene, p-xylene, m-xylene, o-xylene (BTEX), and total BTEX) with serum concentration of AMH. Compared to the first tertile, no statistically significant associations were observed between the second or third tertiles of air pollutants, with the AMH rate of decline. In this study, we did not find significant association between air pollution and AMH in middle age women in Tehran, Iran. Future work may study such associations in younger women.

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Data availability

All data generated or analyzed during this study are included in this published article and datasets used in this research are available upon request from the corresponding author.

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Acknowledgements

The authors acknowledge the Shahid Beheshti University of Medical Sciences for financially supporting this research. H.A. was supported by the Clinical and Translational Science Awards (CTSA) grant UL1TR004419 from the National Center for Advancing Translational Sciences, National Institutes of Health.

Funding

This study was funded by Shahid Beheshti University of Medical Sciences, Tehran, Iran (grant number#43003530).

Author information

Authors and Affiliations

  1. Air Quality and Climate Change Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Zahra Namvar, Anoushiravan Mohseni-Bandpei & Abbas Shahsavani

  2. Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Zahra Namvar, Anoushiravan Mohseni-Bandpei & Abbas Shahsavani

  3. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Heresh Amini

  4. Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA

    Heresh Amini

  5. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam Mousavi & Fahimeh Ramezani Tehrani

  6. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Maryam Mousavi

  7. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Philip K. Hopke

  8. Institute for a Sustainable Environment, Clarkson University, Potsdam, NY, USA

    Philip K. Hopke

  9. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Elahe Shahhosseini

  10. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fariba Khodagholi

  11. Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Seyed Saeed Hashemi

  12. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fereidoun Azizi

Authors
  1. Zahra Namvar
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  2. Anoushiravan Mohseni-Bandpei
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  3. Abbas Shahsavani
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  7. Elahe Shahhosseini
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  11. Fahimeh Ramezani Tehrani
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Contributions

Zahra Namvar: design, conceptualization, writing—original draft. Anoushiravan Mohseni-Bandpei: conceptualization, writing—reviewing and editing. Abbas Shahsavani: conceptualization, supervision, writing—reviewing and editing. Heresh Amini: methodology, modeling, exposure assessment, writing—reviewing and editing. Maryam Mousavi: formal analysis, writing—reviewing and editing. Philip K. Hopke: methodology, writing—reviewing and editing. Elahe Shahhosseini: data collection, writing—reviewing and editing. Fariba Khodagholi: writing—reviewing and editing. Seyed Saeed Hashemi: methodology, formal analysis. Fereidoun Azizi: data collection. Fahimeh Ramezani Tehrani: project administration, design, conceptualization, writing—reviewing and editing.

Corresponding author

Correspondence to Fahimeh Ramezani Tehrani.

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Ethics code (IR.SBMU.ENDOCRINE.REC.1401.110) was approved by the ethics committee of Shahid Beheshti University of Medical Sciences.

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The authors declare no competing interests.

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Namvar, Z., Mohseni-Bandpei, A., Shahsavani, A. et al. Long-term exposure to air pollution and anti-mullerian hormone rate of decline: a population-based cohort study in Tehran, Iran. Environ Sci Pollut Res 30, 86987–86997 (2023). https://doi.org/10.1007/s11356-023-28394-z

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