Abstract
In the current study, we assessed the impact of DMA (dimethylarsinic acid) and MPs (microplastics) interactions in C. elegans over the course of five generations. We found that the redox state of the organisms changed over generations as a result of exposure to both pollutants. From the third generation onward, exposure to MPs reduced GST activity, indicating reduced detoxifying abilities of these organisms. Additionally, dimethylarsinic exposure decreased the growth of organisms in the second, fourth, and fifth generations. In comparison to isolated pollutants, the cumulative effects of co-exposure to DMA and MPs seem to have been more harmful to the organisms, as demonstrated by correlation analysis. These findings demonstrate that DMA, despite being considered less hazardous than its inorganic equivalents, can still have toxic effects on species at low concentrations and the presence of MPs, can worsen these effects.
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Acknowledgements
Juliane Ventura-Lima and José Marìa Monserrat are research productivity fellowship from the Brazilian agency Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), process numbers PQ 313707/2020-0 and PQ 307888/2020-7, respectively. Larissa Müller and Gabriela Soares receives fellowship of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Marcelo Estrella Josende recipient of pos-doctoral fellowship CAPES Program. The authors would like to thank Marcos Gelesky and Tito Cadaval Júnior by characterizations analysis of microplastics. This study was financed by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)- edital 07/2021).
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Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS- Process number: 21/2551-0001968-9).
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Larissa Müller: conceptualization, methodology, validation, formal analysis, investigation, data curation, writing–original draft, writing–review & editing, visualization, project administration.
Marcelo Estrella Josende: formal analysis, investigation, data curation.
Gabriela Corrêa Soares: formal analysis, investigation, data curation.
José Marìa Monserrat: conceptualization, methodology, resources, writing–original draft, writing–review & editing, visualization, supervision, funding acquisition.
Juliane Ventura-Lima: conceptualization, methodology, validation, formal analysis, resources, data curation, project administration, writing–original draft, writing–review & editing, visualization, supervision, funding acquisition.
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Müller, L., Josende, M.E., Soares, G.C. et al. Multigenerational effects of co-exposure to dimethylarsinic acid and polystyrene microplastics on the nematode Caenorhabditis elegans. Environ Sci Pollut Res 30, 85359–85372 (2023). https://doi.org/10.1007/s11356-023-28050-6
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DOI: https://doi.org/10.1007/s11356-023-28050-6