Abstract
Hexaflumuron has been globally registered over 2 decades to control the pests in brassicaceous vegetables, while data on its dissipation and residues in turnip and cauliflower is scarce. Herein, field trials were carried out at six representative experimental sites to study the dissipation behaviors and terminal residues of hexaflumuron in turnip and cauliflower. The residual amounts of hexaflumuron were extracted using a modified QuEChERS and analyzed with liquid chromatography-tandem mass spectrometry (HPLC–MS/MS), the chronic dietary risk to Chinese populations was evaluated, and the maximum residue limit (MRL) in cauliflower, turnip tubers, and turnip leaves was calculated by the OECD MRL calculator. The single first-order kinetics model was the best-fitted kinetics model for hexaflumuron dissipation in cauliflower. The indeterminate order rate equation and first-order multi-compartment kinetic model were the best formulae for hexaflumuron dissipation in turnip leaves. The half-lives of hexaflumuron ranged from 0.686 to 1.35 and 2.41 to 6.71 days in cauliflower and turnip leaves, respectively. The terminal residues of hexaflumuron in turnip leaves of 0.321–9.59 mg/kg were much higher than in turnip tubers of < 0.01–0.708 mg/kg and cauliflower of < 0.01–1.49 mg/kg at sampling intervals of 0, 5, 7, and 10 days. The chronic dietary risk of hexaflumuron in the preharvest interval of 7 days was lower than 100% and much higher than 0.01%, indicating acceptable but nonnegligible health hazards for Chinese consumers. Therefore, MRL values of hexaflumuron were proposed as 2, 0.8, and 10 mg/kg in cauliflower, turnip tubers, and turnip leaves, respectively.
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References
Anastassiades M, Lehotay SJ, Stajnbaher D, Schenck FJ (2003) Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J AOAC Int 86(2):412–431
Cano-Lamadrid M, Nowicka P, Hernández F, Carbonell-Barrachina AA, Wojdyło A (2018) Phytochemical composition of smoothies combining pomegranate juice (Punica granatum L) and Mediterranean minor crop purées (Ficus carica, Cydonia oblonga, and Ziziphus jujube). J Sci Food Agric 98(15):5731–5741
Chen S, Cai L, Zhang H, Zhang Q, Song J, Zhang Z, Deng Y, Liu Y, Wang X, Fang H (2021) Deposition distribution, metabolism characteristics, and reduced application dose of difenoconazole in the open field and greenhouse pepper ecosystem. Agric Ecosyst Environ 313:107370
Di S, Wang Y, Xu H, Wang X, Yang G, Chen C, Yang X, Qian Y (2021) Comparison the dissipation behaviors and exposure risk of carbendazim and procymidone in greenhouse strawberries under different application method: individual and joint applications. Food Chem 354:129502
Ebeling M, Hammel K (2020) Evaluating plant residue decline data with KinGUII and TREC: results from case studies involving also non-SFO kinetic models. Environ Sci Eur 32:16
European Commission (2022) Analytical quality control and method validation procedures for pesticide residue analysis in food and feed, SANTE/11312/2021. https://www.eurl-pesticides.eu/userfiles/file/EurlALL/SANTE_11312_2021.pdf. Accessed 23 May 2023
Fantke P, Juraske R (2013) Variability of pesticide dissipation half-lives in plants. Environ Sci Technol 47(8):3548–3562
Fantke P, Gillespie BW, Juraske R, Jolliet O (2014) Estimating half-lives for pesticide dissipation from plants. Environ Sci Technol 48(15):8588–8602
Farha WZ, Abd El-Aty AM, Rahman MM, Jeong JH, Shin H, Wang J, Shin S, Shim J (2018) Analytical approach, dissipation pattern and risk assessment of pesticide residue in green leafy vegetables: a comprehensive review. Biomed Chromatogr 32:e4134
Feng X, Pan L, Wang C, Zhang H (2017) Residue analysis and risk assessment of pyrethrins in open field and greenhouse turnips. Environ Sci Pollut Res 25:877–886
Ge Q, Mei J, Chen S, Zhang Q, Xue Y, Yu Y, Fang H (2020) Deposition, dissipation, and minimum effective dosage of the fungicide carbendazim in the pepper-field ecosystem. Pest Manag Sci 76:907–916
Hassanen EI, Hussien AM, Mehanna S, Ibrahim MA, Hassan N (2022a) Comparative assessment on the probable mechanisms underlying the hepatorenal toxicity of commercial imidacloprid and hexaflumuron formulations in rats. Environ Sci Pollut Res 29:29091–29104
Hassanen EI, Hussien AM, Hassan N, Ibrahim MA, Mehanna S (2022b) A comprehensive study on the mechanistic way of hexaflumuron and hymexazol induced neurobehavioral toxicity in rats. Neurochem Res 47:3051–3062
Huang F, Guo Z, Chen L, Xu Z, Liu Y, Yang C (2010) Dissipation and evaluation of hexaflumuron residues in Chinese cabbage grown in open fields. J Agri Food Chem 58(8):4839–4843
Jin SG (2008) The Tenth Report of Nutrition and Health Status for China Residents: Nutrition and Health Status of Annual 2002. People’s Medical Publishing House, Beijing
Ju C, Zhang H, Yao S, Dong S, Cao D, Wang F, Fang H, Yu Y (2019) Uptake, translocation, and subcellular distribution of azoxystrobin in wheat plant (Triticum aestivum L.). J Agri Food Chem 67:6691–6699
Ju C, Li X, He S, Shi L, Yu S, Wang F, Xu S, Cao D, Fang H, Yu Y (2020) Root uptake of imidacloprid and propiconazole is affected by root composition and soil characteristics. J Agri Food Chem 68:15381–15389
Lan T, Yang G, Li J, Chi D, Zhang K (2022) Residue, dissipation and dietary intake risk assessment of tolfenpyrad in four leafy green vegetables under greenhouse conditions. Food Chem X 13:100241
Li F, Piao X, Qin D, Luo Y, Liao X, Ji Y (2020) Innovative practice of pesticide residue risk management on minor crops. Pestic Sci Adm 41(6):1–7 (in Chinese)
Li F, Dong F, Yang J, Luo Y, Gao X, Piao X, Shan W, Huang X (2022a) Current status and the prospect of pesticide application risk management on minor crops. Modern Agrochemicals 21(5):1–6 (in Chinese)
Li J, Lan T, Yang G, Mu S, Zhang K (2022b) Enantioselective evaluation of the chiral fungicide mandipropamid: dissipation, distribution and potential dietary intake risk in tomato, cucumber, Chinese cabbage and cowpea. Ecotoxicol Environ Saf 232:113260
Liu Q, Gao H, Yi X, Tian S, Liu X (2022) Root uptake pathways and cell wall accumulation mechanisms of organophosphate esters in wheat (Triticum Aestivum L.). J Agri Food Chem 70:11892–11900
Liu J, Cheng J, Zhou C, Ma L, Chen X, Li Y, Sun X, Yan X, Geng R, Wan Q, Yu X (2023) Uptake kinetics and subcellular distribution of three classes of typical pesticides in rice plants. Sci Total Environ 858:159826
López-López T, Martínez-vidal JL, Gil-García MD, Martínez-galera M, Rodríguez-Lallena JA (2004) Benzoylphenylurea residues in peppers and zucchinis grown in greenhouses: determination of decline times and pre-harvest intervals by modelling. Pest Manag Sci 60(2):183–190
Mao J, Liu B, Guo D, Jian W (2011) The residue and degradation of hexaflumuron in soil and cotton. Soil Environ Sci 20(2):364–367 (in Chinese)
Mei J, Ge Q, Han L, Zhang H, Long Z, Cui Y, Hua R, Yu Y, Fang H (2019) Deposition, distribution, metabolism and reduced application dose of thiamethoxam in a pepper-planted ecosystem. J Agri Food Chem 67:11848–11859
Ministry of Agriculture and Rural Affairs of the People’s Republic of China (2004) Guideline on pesticide residue trials, NY/T788-2004. Qual Saf Agro-Prod 4:29–33 (in Chinese)
Noaishi MA, Abd HH, Abdulrahman SA (2019) Evaluation of the repeated exposure of hexaflumuron on liver and spleen tissues and its mutagenicity ability in male Albino rat. Egypt J Hosp Med 76:4545–4552
OECD (2011) Maximum residue limit calculator. https://www.oecd.org/env/ehs/pesticides-biocides/oecdmaximumresiduelimitcalculator.htm Accessed 15 February 2023
Ranke J, Wöltjen J, Meinecke S (2018) Comparison of software tools for kinetic evaluation of chemical degradation data. Environ Sci Eur 30(1):17
Sandín-España P, Mateo-Miranda M, López-Goti C, Seris-Barrallo E, Alonso-Prados JL (2022) Analysis of pesticide residues by QuEChERS method and LC-MS/MS for a new extrapolation of maximum residue levels in persimmon minor crop. Molecules 27(5):1517
Soler C, James KJ, Picó Y (2007) Capabilities of different liquid chromatography tandem mass spectrometry systems in determining pesticide residues in food. Application to estimate their daily intake. J Chromatogr A 1157(1–2):73–84
Song J, Zheng Z, Fang H, Li T, Wu Z, Qiu M, Shen H, Mei J, Xu L (2023) Deposition and dissipation of difenoconazole in pepper and soil and its reduced application to control pepper anthracnose. Ecotoxicol Environ Saf 252:114591
Sun C, Zhang H, Tang T, Qian M, Yuan Y, Zhang Z (2012) Comparison of greenhouse and field degradation behaviour of isoprocarb, hexaflumuron and difenoconazole in Perilla frutescens. Bull Environ Contam Toxicol 89(4):868–872
Tanani MA, Hasaballah A, Hussein RM (2022) Assessment of the perturbation induced by chitin synthesis inhibitors lufenuron, flufenoxuron and hexaflumuron in the house fly, Musca domestica vicina (Diptera: Muscidae). JoBAZ 83:29
Wang Z, Di S, Qi P, Xu H, Zhao H, Wang X (2020) Dissipation, accumulation and risk assessment of fungicides after repeated spraying on greenhouse strawberry. Sci Total Environ 758:144067
Wang R, Yang Y, Deng Y, Hu D, Lu P (2022) Multiresidue analysis and dietary risk assessment of pesticides in eight minor vegetables from Guizhou, China. Food Chem 380:131863
Xu J, Long X, Ge S, Li M, Chen L, Hu D, Zhang Y (2019) Deposition amount and dissipation kinetics of difenoconazole and propiconazole applied on banana with two commercial spray adjuvants. RSC Adv 9:19780–19790
Xu Z, Li L, Xu Y, Wang S, Zhang X, Tang T, Yu J, Zhao H, Wu S, Zhang C, Zhao X (2021) Pesticide multi-residues in Dendrobium officinale Kimura et Migo: method validation, residue levels, and dietary exposure risk assessment. Food Chem 343:128490
Yu P, Li Y, Zou L, Liu B, Xiang L, Zhao H, Li H, Cai Q, Hou X, Mo CH, Wong MH, Li QX (2021) Variety-selective rhizospheric activation, uptake, and subcellular distribution of perfluorooctanesulfonate (PFOS) in lettuce (Lactuca sativa L.). Environ Sci Technol 55:8730–8741
Zhang D, Tang J, Zhang G, Wu X, Sun Q, Jia C, Shi T, Fang H, Wu X, Li H, Hua R (2021) Deposition, dissipation, metabolism and dietary risk assessment of chlorothalonil in open field-planted cabbage. J Food Compos Anal 102:104008
Zhou L, Guo L, Liang L, Feng Y, Zhang A, Pan J, Wu Y (2020) Residue and dietary intake risk assessment of hexaflumuron in Chinese chives. Pest Sci Adm 41(1):23–28 (in Chinese)
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Bizhang Dong: material preparation, data collection, analysis, and manuscript draft and review. Jiye Hu: study conception and design, manuscript review, and supervision. All authors read and approved the final manuscript.
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Dong, B., Hu, J. Dissipation patterns, residue analysis, and risk evaluation of hexaflumuron in turnip and cauliflower under Chinese growth conditions. Environ Sci Pollut Res 30, 85534–85544 (2023). https://doi.org/10.1007/s11356-023-28011-z
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DOI: https://doi.org/10.1007/s11356-023-28011-z