Abstract
Polysaccharides that are naturally sourced have enormous promise as wound dressings, due to their wider availability and reasonable cost and good biocompatibility. Furthermore, nanosilver extensively applied in wound treatment is attributed to its broad spectrum of antimicrobial effects and lesser drug resistance. Consequently, wound dressings in corporating nanosilver have attracted wide-scale interest in wound healing, and nanosilver-functionalized polysaccharide-based wound dressings present an affordable option for healing of chronic wounds. This review encompasses preparation methods, classification, and antibacterial performances of nanosilver wound dressings. The prospective research arenas of nanosilver-based wound polysaccharide dressings are also elaborated. The review attempts to include a summary of the most recent advancements in silver nanotechnology as well as guidance for the investigation of nanosilver-functionalized polysaccharide-based wound dressings.
Similar content being viewed by others
Data availability
Not applicable.
Abbreviations
- WHS:
-
Wound Healing Society
- Hh:
-
Hedgehog
- CS:
-
Chitosan
- FDA:
-
Food and Drug Administration
- MW:
-
Molecular weight
- CDs:
-
Cyclodextrins
- GAG:
-
Glycosaminoglycan
- HSV:
-
Herpes simplex virus
- NPs:
-
Nanoparticles
- Ag-NPs:
-
Silver nanoparticles
- MMP:
-
Matrix metalloproteinase
- PS-AgNPs:
-
Polysaccharides silver nanoparticles
- NHEK:
-
Natural human epidermal keratinocytes
- SSD:
-
Silver sulfadiazine
- PEH:
-
Polyelectrolyte hydrogels
References
Abouelkheir SS, Kamara MS, Atia SM, Amer SA, Youssef MI, Abdelkawy RS et al (2020) Novel research on nanocellulose production by a marine Bacillus velezensis strain SMR: a comparative study. Sci Rep 10(1):1–14
Ahmed F, Arbab AA, Jatoi AW, Khatri M, Memon N, Khatri Z, Kim IS (2017) Ultrasonic-assisted deacetylation of cellulose acetate nanofibers: a rapid method to produce cellulose nanofibers. UltrasonSonochem 36:319–325
Alberti T, Coelho SD, Voytena A, Pitz H, de Pra M, Mazzarino L et al (2017) Nanotechnology: a promising tool towards wound healing. Curr Pharm Des 23(24):3515–3528
Albino S, Vieira T, Silva JC (2022) Silver nanoparticles formation and PVP crosslinking using UV-radiation. Mater Proc 8(1):86
Alizadeh L, Zarebkohan A, Salehi R, Ajjoolabady A, Rahmati-Yamchi M (2019) Chitosan-based nanotherapeutics for ovarian cancer treatment. J Drug Target 27(8):839–852
Allard J, Mogilner A (2013) Traveling waves in actin dynamics and cell motility. CurrOpin Cell Biol 25(1):107–115
Apasuthirat A, Rungsilp S (2015) US Patent Application No 14/402503
Baltzis D, Eleftheriadou I, Veves A (2014) Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights. Adv Ther 31(8):817–836
Banks SR, Enck K, Wright M, Opara EC, Welker ME (2019) Chemical modification of alginate for controlled oral drug delivery. J Agric Food Chem 67(37):10481–10488
Bapat RA, Chaubal TV, Joshi CP, Bapat PR, Choudhury H, Pandey M et al (2018) An overview of application of silver nanoparticles for biomaterials in dentistry. Mater Sci Engg C 91:881–898
Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M (2014) Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 22(5):569–578
Bioster AS (2021) Traumacel FAM trium in the post-market surveillance phase. NCT05177874
BuganzaTepole A, Kuhl E (2016) Computational modeling of chemo-bio-mechanical coupling: a systems-biology approach toward wound healing. Comput Methods Biomech Biomed Engg 19(1):13–30
Burgert L, Hrdina R, Velebny V, Abdel-Lattif AM, Sulakova R, Sobotka L, et al (2015) Methods and compositions for wound healing. US patent application No 14/400111
Buruaga-Ramiro C, Valenzuela SV, Valls C, Roncero MB, Pastor FJ, Díaz P, Martinez J (2020) Development of an antimicrobial bioactive paper made from bacterial cellulose. Int J BiolMacromol 158:587–594
Carrion CC, Nasrollahzadeh M, Sajjadi M, Jaleh B, Soufi GJ, Iravani S (2021) Lignin lipid protein hyaluronic acid starch cellulose gum pectin alginate and chitosan-based nanomaterials for cancer nanotherapy: challenges and opportunities. Int J BiolMacromol 178:193–228
Chen S, Chen H, Tian J, Wang Y, Xing L, Wang J (2013) Chemical modification antioxidant and α-amylase inhibitory activities of corn silk polysaccharides. CarbohydrPolym 98(1):428–437
Chen C, Wu W, Xu X, Zhang L, Liu Y, Wang K (2014a) Chain conformation and anti-tumor activity of derivatives of polysaccharide from RhizomaPanacisJaponici. CarbohydrPolym 105:308–316
Chen Y, Zhang H, Wang Y, Nie S, Li C, Xie M (2014b) Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities. Food Chem 156:279–288
Chen Y, Yao F, Ming K, Wang D, Hu Y, Liu J (2016) Polysaccharides from traditional Chinese medicines: extraction purification modification and biological activity. Molecules 21(12):1705
Chen K, Sivaraj D, Davitt MF, Leeolou MC, Henn D, Steele SR et al (2022) Pullulan-collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings. Wound Repair Regen 30(3):397–408
Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016) Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol 7:30
Concórdio-Reis P, Pereira CV, Batista MP, Sevrin C, Grandfils C, Marques AC et al (2020) Silver nanocomposites based on the bacterial fucose-rich polysaccharide secreted by Enterobacter A47 for wound dressing applications: synthesis characterization and in vitro bioactivity. Int J BiolMacromol 163:959–969
Dev SK, Choudhury PK, Srivastava R, Sharma M (2019) Antimicrobial anti-inflammatory and wound healing activity of polyherbal formulation. Biomed Pharmacother 111:555–567
Devaraj V, Bose B (2019) Morphological state transition dynamics in EGF-induced epithelial to mesenchymal transition. J Clin Med 8(7):911
Donati I, Marsich E, Travan A, Paoletti S (2011) Wound dressing comprising bio - cellulose and silver nanoparticles. US Patent Application No 13/055349
Du X, Zhang J, Lv Z, Ye L, Yang Y, Tang Q (2014) Chemical modification of an acidic polysaccharide (TAPA1): from Tremella aurantialba and potential biological activities. Food Chem 143:336–340
Duan H, Donovan M, Foucher A, Schultze X, Lecommandoux S (2018) Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition. Sci Rep 8(1):1–9
Duda M (2020) US Patent No 10639469 Washington DC: US Patent and Trademark Office
El-Deeb NM, Abo-Eleneen MA, Al-Madboly LA, Sharaf MM, Othman SS, Ibrahim OM, Mubarak MS (2020) Biogenically synthesized polysaccharides-capped silver nanoparticles: immunomodulatory and antibacterial potentialities against resistant Pseudomonas aeruginosa. Front BioengBiotechnol 8:643
Eng Kean Yeong (2014) To study the effect of β-glucans on wound healing. NCT02078128
Fan R, Zhu C, Qiu D, Mao G, Zeng J (2020) Activation of RAW264 7 macrophages by an acidic polysaccharide derived from Citrus grandis ‘Tomentosa.’ Int J BiolMacromol 156:1323–1329
Fontana F, Mori M, Riva F, Makila E, Liu D, Salonen J et al (2016) Platelet lysate-modified porous silicon microparticles for enhanced cell proliferation in wound healing applications. ACS Appl Mater Interfaces 8(1):988–996
Foy M, Anézo O, Saule S, Planque N (2017) PRL-3/PTP4A3 phosphatase regulates integrin β1 in adhesion structures during migration of human ocular melanoma cells. Exp Cell Res 353(2):88–99
Franková J, Pivodová V, Vágnerová H, Juráňová J, Ulrichová J (2016) Effects of silver nanoparticles on primary cell cultures of fibroblasts and keratinocytes in a wound-healing model. J ApplBiomaterFunct Mater 14(2):137–142
Fuenzalida PJ, Goycoolea MF (2015) Polysaccharide-protein nanoassemblies: novel soft materials for biomedical and biotechnological applications. Curr Protein Pept Sci 16(2):89–99
Fumakia M, Ho EA (2016) Nanoparticles encapsulated with LL37 and serpin A1 promotes wound healing and synergistically enhances antibacterial activity. Mol Pharm 13(7):2318–2331
Garcia-Orue I, Santos-Vizcaino E, Etxabide A, Uranga J, Bayat A, Guerrero P et al (2019) Development of bioinspired gelatin and gelatin/chitosan bilayer hydrofilms for wound healing. Pharmaceutics 11(7):314
Ghosh S, Turner RJ (2021) Nanomicrobiology: emerging trends in microbial synthesis of nanomaterials and their applications. Front Microbiol 12:751693
Gomathysankar S, Halim AS, Yaacob NS (2014) Proliferation of keratinocytes induced by adipose-derived stem cells on a chitosan scaffold and its role in wound healing a review. Arch Plast Surg 41(05):452–457
Gonzalez ACDO, Costa TF, Andrade ZDA, Medrado ARAP (2016) Wound healing-a literature review. Anbras Dermatol 91:614–620
Guo R, Chen M, Ding Y, Yang P, Wang M, Zhang H, et al (2022) Polysaccharides as potential anti-tumor biomacromolecules—a review. Front Nutr 9:9838179
Hashimoto Y, Mukai SA, Sasaki Y, Akiyoshi K (2018) Nanogel tectonics for tissue engineering: protein delivery systems with nanogel chaperones. Adv Health Mater 7(23):1800729
Hurlow J, Couch K, Laforet K, Bolton L, Metcalf D, Bowler P (2015) Clinical biofilms: a challenging frontier in wound care. Adv Wound Care 4(5):295–301
Jahromi MAM, Zangabad PS, Basri SMM, Zangabad KS, Ghamarypour A, Aref AR et al (2018) Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing. Adv Drug Deliv Rev 123:33–64
Jung HY, Bae IY, Lee S, Lee HG (2011) Effect of the degree of sulfation on the physicochemical and biological properties of Pleurotuseryngii polysaccharides. Food Hydrocoll 25(5):1291–1295
Junker JP, Kamel RA, Caterson EJ, Eriksson E (2013) Clinical impact upon wound healing and inflammation in moist wet and dry environments. Adv Wound Care 2(7):348–356
Kanwal S, Joseph TP, Owusu L, Xiaomeng R, Meiqi L, Yi X (2018) A polysaccharide isolated from Dictyophoraindusiata promotes recovery from antibiotic-driven intestinal dysbiosis and improves gut epithelial barrier function in a mouse model. Nutrients 10(8):1003
Karaki N, Aljawish A, Humeau C, Muniglia L, Jasniewski J (2016) Enzymatic modification of polysaccharides: Mechanisms properties and potential applications: A review. Enzyme Microb Technol 90:1–18
Kazachenko AS, Malyar YN, Vasilyeva NY, Borovkova VS, Issaoui N (2021) Optimization of guar gum galactomannan sulfation process with sulfamic acid. Biomass Convers Biorefin 11(5):1–10
Khuntia A, Martorell M, Ilango K, Bungau SG, Radu AT, Behl T, Sharifi-Rad J (2022) Theoretical evaluation of Cleome species’ bioactive compounds and therapeutic potential: a literature review. Biomed Pharmacother 151:113161
Kirtane AR, Verma M, Karandikar P, Furin J, Langer R, Traverso G (2021) Nanotechnology approaches for global infectious diseases. Nat Nanotechnol 16(4):369–384
Krylova NV, Ermakova SP, Lavrov VF, Leneva IA, Kompanets GG, Iunikhina OV et al (2020) The comparative analysis of antiviral activity of native and modified fucoidans from brown algae Fucus evanescens in vitro and in vivo. Mar Drugs 18(4):224
Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Nina PB et al (2021) Futuristic non-antibiotic therapies to combat antibiotic resistance: a review. Front Microbiol 12:609459
Kurita O, Miyake Y, Yamazaki E (2012) Chemical modification of citrus pectin to improve its dissolution into water. CarbohydrPolym 87(2):1720–1727
Li S, Shah NP (2014) Antioxidant and antibacterial activities of sulphated polysaccharides from Pleurotuseryngii and Streptococcus thermophilus ASCC 1275. Food Chem 165:262–270
Li S, Xiong Q, Lai X, Li X, Wan M, Zhang J et al (2016) Molecular modification of polysaccharides and resulting bioactivities. Compr Rev Food Sci Food Saf 15(2):237–250
Li J, He J, Huang Y (2017) Role of alginate in antibacterial finishing of textiles. Int J BiolMacromol 94:466–473
Li XX, Dong JY, Li YH, Zhong J, Yu H, Yu QQ et al (2020) Fabrication of Ag–ZnO@ carboxymethyl cellulose/K-carrageenan/graphene oxide/konjac glucomannan hydrogel for effective wound dressing in nursing care for diabetic foot ulcers. ApplNanosci 10(3):729–738
Ligacheva AA, Sherstoboev EY, Danilets MG, Trofimova ES, Krivoshchekov SV, Gur’ev AM et al (2020) Study of immunotropic properties of water-soluble polysaccharides isolated from Conium maculatum grass. Bull Exp Biol Med 170(2):203–206. https://doi.org/10.1007/s10517-020-05033-y
Liu H, Wang J, Zhou W, Wang Y, Yang L (2013) Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice. J Ethnopharmacol 146(3):773–793
Liu Z, Xu D, Xia N, Zhao X, Kong F, Wang S, Fatehi P (2018) Preparation and application of phosphorylated xylan as a flocculant for cationic ethyl violet dye. Polymers 10(3):317
Liu H, Li F, Luo P (2019) Effect of carboxymethylation and phosphorylation on the properties of polysaccharides from Sepia esculenta ink: antioxidation and anticoagulation in vitro. Mar Drugs 17(11):626
Liu D, Ma X, Ji Y, Chen R, Zhou S, Yao H et al (2022) Bioresponsivenanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms. Bioact Mater 14:1–14
Liu M, Xu W, Su M, Fan P (2020) REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells. Biol Res 53:41
Ma L, Chen H, Zhang Y, Zhang N, Fu L (2012) Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus. CarbohydrPolym 89(2):371–378
McAnulty JF, Murphy C, Abbott N (2014) US Patent No 8709393 Washington DC: US Patent and Trademark Office
Mehwish HM, Liu G, Rajoka MSR, Cai H, Zhong J, Song X et al (2021) Therapeutic potential of Moringa oleifera seed polysaccharide embedded silver nanoparticles in wound healing. Int J BiolMacromol 184:144–158
Miao T, Wang J, Zeng Y, Liu G, Chen X (2018) Polysaccharide-based controlled release systems for therapeutics delivery and tissue engineering: from bench to bedside. Adv Sci 5(4):1700513
Millar NL, Gilchrist DS, Akbar M, Reilly JH, Kerr SC, Campbell AL et al (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nat Commun 6(1):1–13
Mohammadinejad R, Kumar A, Ranjbar-Mohammadi M, Ashrafizadeh M, Han SS, Khang G, Roveimiab Z (2020) Recent advances in natural gum-based biomaterials for tissue engineering and regenerative medicine: a review. Polymers 12(1):176
Mohammed ASA, Naveed M, Jost N (2021) Polysaccharides; classification chemical properties and future perspective applications in fields of pharmacology and biological medicine (a review of current applications and upcoming potentialities). J Polym Environ 29(8):2359–2371
Monsuur HN, Boink MA, Weijers EM, Roffel S, Breetveld M, Gefen A et al (2016) Methods to study differences in cell mobility during skin wound healing in vitro. J Biomech 49(8):1381–1387
Mourdikoudis S, Pallares RM, Thanh NT (2018) Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties. Nanoscale 10(27):12871–12934
Mundsinger K, Müller A, Beyer R, Hermanutz F, Buchmeiser MR (2015) Multifilament cellulose/chitin blend yarn spun from ionic liquids. CarbohydrPolym 131:34–40
Narayanan N, Jiang C, Wang C, Uzunalli G, Whittern N, Chen D et al (2020) Harnessing fiber diameter-dependent effects of myoblasts toward biomimetic scaffold-based skeletal muscle regeneration. Front BioenggBiotechnol 8:203
Nawaz A, Zaman SS, Sikandar S, Zeeshan R, Zulfiqar S, Mehmood N et al (2022) Heparin-loaded alginate hydrogels: characterization and molecular mechanisms of their angiogenic and anti-microbial potential. Materials 15(19):6683
Nour S, Baheiraei N, Imani R, Khodaei M, Alizadeh A, Rabiee N et al (2019) A review of accelerated wound healing approaches: biomaterial-assisted tissue remodeling. J Mater Sci Mater Med 30(10):1–15
Nqakala ZB, Sibuyi NRS, Fadaka AO, Meyer M, Onani MO, Madiehe AM (2021) Advances in nanotechnology towards development of silver nanoparticle-based wound-healing agents. Int J Mol Sci 22(20):11272
Omer AM, Tamer TM, Khalifa RE, Eltaweil AS, Agwa MM, Sabra S et al (2021) Formulation and antibacterial activity evaluation of quaternizedaminochitosan membrane for wound dressing applications. Polymers 13(15):2428
Ortega MA, Fraile-Martínez O, García-Montero C, Álvarez-Mon MA, Chaowen C, Ruiz-Grande F et al (2021) Understanding chronic venous disease: a critical overview of its pathophysiology and medical management. J Clin Med 10(15):3239
Pachuau L (2015) Recent developments in novel drug delivery systems for wound healing. Expert Opin Drug Deliv 12(12):1895–1909
Pazyar N, Houshmand G, Yaghoobi R, Hemmati AA, Zeineli Z, Ghorbanzadeh B (2019) Wound healing effects of topical vitamin K: a randomized controlled trial. Indian J Pharmacol 51(2):88
Petkova MD, Tkačik G, Bialek W, Wieschaus EF, Gregor T (2019) Optimal decoding of cellular identities in a genetic network. Cell 176(4):844–855
Qiu A, Wang Y, Zhang G, Wang H (2022) Natural polysaccharide-based nanodrug delivery systems for treatment of diabetes. Polymers 14(15):3217
Rajendran NK, Kumar SSD, Houreld NN, Abrahamse H (2018) A review on nanoparticle based treatment for wound healing. J Drug Deliv Sci Technol 44:421–430
Rakita A, Nikolić N, Mildner M, Matiasek J, Elbe-Bürger A (2020) Re-epithelialization and immune cell behaviour in an ex vivo human skin model. Sci Rep 10(1):1–11
Rao KM, Kumar A, Haider A, Han SS (2016) Polysaccharides based antibacterial polyelectrolyte hydrogels with silver nanoparticles. Mater Lett 184:189–192
Rath G, Hussain T, Chauhan G, Garg T, Goyal AK (2016) Development and characterization of cefazolin loaded zinc oxide nanoparticles composite gelatin nanofiber mats for postoperative surgical wounds. Mater Sci Eng C 58:242–253
Roshidi MDA, Fen YW, Daniyal WMEMM, Omar NAS, Zulholinda M (2019) Structural and optical properties of chitosan–poly (amidoamine): dendrimer composite thin film for potential sensing Pb2+ using an optical spectroscopy. Optik 185:351–358
Sachdeva R, Fleming T, Schumacher D, Homberg S, Stilz K, Mohr F et al (2019) Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels. Cell Calcium 78:66–75
Saghazadeh S, Rinoldi C, Schot M, Kashaf SS, Sharifi F, Jalilian E et al (2018) Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev 127:138–166
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A et al (2013) The way Wnt works: components and mechanism. Growth Factors 31(1):1–31
Sajjad W, Khan T, Ul-Islam M, Khan R, Hussain Z, Khalid A, Wahid F (2019) Development of modified montmorillonite-bacterial cellulose nanocomposites as a novel substitute for burn skin and tissue regeneration. CarbohydrPolym 206:548–556
Sanchis-Gomar F, Arnau-Moyano M, Daimiel L, Lippi G, Leischik R, Vallecillo N et al (2021) Circulating microRNAs fluctuations in exercise-induced cardiac remodeling: a systematic review Am J. Transl Res 13(12):13298
Santos R, Gomes D, Macedo H, Barros D, Tibério C, Veiga AS et al (2016) Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates. J Med Microbiol 65(10):1092–1099
Sarder R, Piner E, Rios DC, Chacon L, Artner MA, Barrios N, Argyropoulos D (2022) Copolymers of starch a sustainable template for biomedical applications: a review. CarbohydrPolym 278:118973
Saxena SK, Nyodu R, Kumar S, Maurya VK (2020) Current advances in nanotechnology and medicine. In: Saxena S, Khurana S (eds) NanoBioMedicine. Springer, Singapore, pp 3–16. https://doi.org/10.1007/978-981-32-9898-9_1
Shankar PD, Shobana S, Karuppusamy I, Pugazhendhi A, Ramkumar VS, Arvindnarayan S, Kumar G (2016) A review on the biosynthesis of metallic nanoparticles (gold and silver): using bio-components of microalgae: Formation mechanism and applications. Enzyme Microb Technol 95:28–44
Sharma V, Gautam DNS, Radu AF, Behl T, Bungau SG, Vesa CM (2022) Reviewing the traditional/modern uses, phytochemistry, essential oils/extracts and pharmacology of embelia ribes burm. Antioxidants 11(7):1359
Shrivastav A, Mishra AK, Ali SS, Ahmad A, Abuzinadah MF, Khan NA (2018) In vivo models for assesment of wound healing potential: a systematic review. Wound Med 20:43–53
Singh D, Han SS, Shin EJ (2014) Polysaccharides as nanocarriers for therapeutic applications. J Biomed Nanotechnol 10(9):2149–2172
Sinha S, Astani A, Ghosh T, Schnitzler P, Ray B (2010) Polysaccharides from Sargassum tenerrimum: structural features chemical modification and anti-viral activity. Phytochemistry 71(2–3):235–242
Soto-Cruz J, Mukwaya V, Naz M, Zhang P, López-Brenes MJ, Sáenz-Arce G et al (2022) Polysaccharide/lipid nanoconjugates as alternative building blocks for highly biocompatible microcapsules. Langmuir 38(31):9556–9566
Spallotta F, Cencioni C, Straino S, Sbardella G, Castellano S, Capogrossi MC et al (2013) Enhancement of lysine acetylation accelerates wound repair. CommunIntegr Biol 6(5):e25466
Stettler H, Kurka P, Wagner C, Sznurkowska K, Czernicka O, Böhling A et al (2017) A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults and tolerability in healthy infants. J Dermatolog Treat 28(3):251–257
Sun Y, Ma X, Hu H (2021) Marine polysaccharides as a versatile biomass for the construction of nano drug delivery systems. Mar Drugs 19(6):345
Taghipour YD, Hokmabad VR, Bakhshayesh D, Rahmani A, Asadi N, Salehi R, Nasrabadi HT (2020) The application of hydrogels based on natural polymers for tissue engineering. Curr Med Chem 27(16):2658–2680
Thiruvoth FM, Mohapatra DP, Kumar D, Chittoria SRK, Nandhagopal V (2015) Current concepts in the physiology of adult wound healing. PlastAesthet Res 2:250–256
Thuy TTT, Ly BM, Van TTT, Van Quang N, Tu HC, Zheng Y et al (2015) Anti-HIV activity of fucoidans from three brown seaweed species. CarbohydrPolym 115:122–128
Ting-Chang C (2019) EGF-loaded chitosan to facilitate healing and prevent scar formation of cesarean wound. NCT04211597
Tiwari G, Yadav D, Singh B, Kumar A, Wal P, Tiwari R (2022) Development and assessment of phytophospholipid nanovesicular systems for treatment of diabetic neuropathy. Pharmacognosy Res 14(4):360–368
Toppo FA, Pawar RS (2015) Novel drug delivery strategies and approaches for wound healing managements. J Crit Rev 2(2):12À20
Traore YL, Fumakia M, Gu J, Ho EA (2018) Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery. Jbiomater Appl 32(8):1119–1126
Tummino ML, Tolardo V, Malandrino M, Sadraei R, Magnacca G, Laurenti E (2020) A way to close the loop: physicochemical and adsorbing properties of soybean hulls recovered after soybean peroxidase extraction. Front Chem 8:763
Uddin TM, Chakraborty AJ, Khusro A, Zidan BRM, Mitra S, Emran TB et al (2021) Antibiotic resistance in microbes: History mechanisms therapeutic strategies and future prospects. J Infect Public Health 14(12):1750–1766
Ud-Din S, Bayat A (2017) Non-animal models of wound healing in cutaneous repair: in silico in vitro ex vivo and in vivo models of wounds and scars in human skin. Wound Repair Regen 25(2):164–176
Vasconcelos AFD, Dekker RF, Barbosa AM, Carbonero ER, Silveira JL, Glauser B et al (2013) Sulfonation and anticoagulant activity of fungal exocellular β-(1→ 6):-D-glucan (lasiodiplodan). CarbohydrPolym 92(2):1908–1914
Velnar T, Gradisnik L (2018) Tissue augmentation in wound healing: the role of endothelial and epithelial cells. Med Arch 72(6):444
Vitali F, Mulas F, Marini P, Bellazzi R (2013) Network-based target ranking for polypharmacological therapies. J Biomed Inform 46(5):876–881
Wal P, Saraswat N, Vig H (2022) A detailed insight onto the molecular and cellular mechanism of action of the antifungal drugs used in the treatment of superficial fungal infections. Curr Drug Ther 17(3):148–159
Wal P, Wal A, Pal RS, Pal Y, Saraswat N (2021) An ayurvedic based dermal treatment for skin sanitization. Open Dermatol J 15(1):59–64
Wan W, Guhados G (2015) US Patent No 9200086 Washington DC: US Patent and Trademark Office
Wang H, Dai T, Li S, Zhou S, Yuan X, You J et al (2018) Scalable and cleavable polysaccharide nanocarriers for the delivery of chemotherapy drugs. Acta Biomater 72:206–216
Wang J, Li Y, Nie G (2021) Multifunctional biomolecule nanostructures for cancer therapy. Nat Rev Mater 6(9):766–783
Wasef LG, Shaheen HM, El-Sayed YS, Shalaby TI, Samak DH, El-Hack A et al (2020) Effects of silver nanoparticles on burn wound healing in a mouse model. Biol Trace Elem Res 193(2):456–465
Wen Y, Oh JK (2014) Recent strategies to develop polysaccharide-based nanomaterials for biomedical applications. Macromol Rapid Commun 35(21):1819–1832
Wilhelm KP, Wilhelm D, Bielfeldt S (2017) Models of wound healing: an emphasis on clinical studies. Skin Res Technol 23(1):3–12
Xie G, Diehl AM (2013) Evidence for and against epithelial-to-mesenchymal transition in the liver. Am J Physiol Gastrointest Liver Physiol 305(12):G881–G890
Xu Y, Wu YJ, Sun PL, Zhang FM, Linhardt RJ, Zhang AQ (2019) Chemically modified polysaccharides: synthesis characterization structure activity relationships of action. Int J BiolMacromol 132:970–977
Yadav SK, Singla R, Kumari A (2019) Nanocomposite materials based on metallic NPs stabilized with branched polysaccharides. US Patent No 10426809 Washington DC: US Patent and Trademark Office
Yadi M, Mostafavi E, Saleh B, Davaran S, Aliyeva I, Khalilov R et al (2018) Current developments in green synthesis of metallic nanoparticles using plant extracts: a review. Artif Cells NanomedBiotechnol 46(sup3):S336–S343
Yamazaki T, Mukouyama YS (2018) Tissue specific origin development and pathological perspectives of pericytes. Front Cardiovasc Med 5:78
Yan JK, Pei JJ, Ma HL, Wang ZB (2015) Effects of ultrasound on molecular properties structure chain conformation and degradation kinetics of carboxylic curdlan. CarbohydrPolym 121:64–70
Yang J, Yang H (2021) Non-antibiotic therapy for Clostridioides difficile infection: a review. Crit Rev Clin Lab Sci 56(7):493–509
Yang X, Shi X, D’arcy R, Tirelli N, Zhai G (2018) Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases. J Control Release 272:114–144
Yazdi MK, Ganjali MR, Zarrintaj P, Bagheri B, Kim YC, Saeb MR (2021) Ionically gelled carboxymethyl polysaccharides for drug delivery. ionically gelled biopolysaccharide based systems in drug delivery. Springer, Singapore, pp 93–103
Ye H, Cheng J, Yu K (2019) In situ reduction of silver nanoparticles by gelatin to obtain porous silver nanoparticle/chitosan composites with enhanced antimicrobial and wound-healing activity. Int J BiolMacromol 121:633–642
Yu X, Zhou C, Yang H, Huang X, Ma H, Qin X, Hu J (2015) Effect of ultrasonic treatment on the degradation and inhibition cancer cell lines of polysaccharides from Porphyrayezoensis. CarbohydrPolym 117:650–656
Zhang N, Chen H, Ma L, Zhang Y (2013) Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties. Int J BiolMacromol 54:209–215
Zhang M, Su N, Huang Q, Zhang Q, Wang Y, Li J, Ye M (2017) Phosphorylation and antiaging activity of polysaccharide from Trichosanthes peel. J Food Drug Anal 25(4):976–983
Zhang Y, Wang X, Zhang Y, Liu Y, Wang D, Yu X et al (2021) Endothelial cell migration regulated by surface topography of poly (ε-caprolactone): nanofibers. ACS Biomater Sci Eng 7(10):4959–4970
Zhang Z, Wang X, Zhao M, Qi H (2014) O-acetylation of low-molecular-weight polysaccharide from Enteromorpha linza with antioxida activity. Int J Biol Macromol 69:39–45
Zhang X, Xu R, Hu X, Luo G, Wu J, He WA (2015) systematic and quantitative method for wound-dressing evaluation. Burns Trauma 3:1–8
Zhang J, Shachaf C (2018) Sock for treatment of foot and leg wounds, methods of use and manufacture. US Patent No 10064793 Washington DC: US Patent and Trademark Office
Acknowledgements
The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number ISP22-10.
Funding
This research was funded by Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia through the project number ISP22-10.
Author information
Authors and Affiliations
Contributions
PW, KP, SM, and TB: Conceived the study and wrote the first draft of the paper; MK, SM and HAA: Data compilation; GK and AK: Editing; TB and SM: Proof Read.
Corresponding author
Ethics declarations
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publish
All the authors have approved the manuscript for publication.
Competing interests
The authors’ declare no competing interests.
Additional information
Responsible Editor: Lotfi Aleya
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Mohan, S., Wal, P., Pathak, K. et al. Nanosilver-functionalized polysaccharides as a platform for wound dressing. Environ Sci Pollut Res 30, 54385–54406 (2023). https://doi.org/10.1007/s11356-023-26450-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-023-26450-2