Abstract
Heavy metal exposure has been reported to be correlated with lipid profile alteration and dyslipidemia. While the associations between serum cobalt (Co) with lipid profile levels and risk of dyslipidemia have not been explored in elderly population, and the underlying mechanisms remain unclear. All eligible 420 elderly people were recruited in three communities of Hefei City in this cross-sectional study. Peripheral blood samples and clinical information were collected. The level of serum Co was detected through ICP-MS. The biomarkers for systemic inflammation (TNF-α) and lipid peroxidation (8-iso-PGF2α) were measured with ELISA. Each 1-unit increase of serum Co was related with 0.513 mmol/L, 0.196 mmol/L, 0.571 mmol/L, and 0.303 g/L in TC, TG, LDL-C, and ApoB, respectively. Multivariate linear and logistic regression analyses indicated that the prevalence of elevated TC, elevated LDL-C, and elevated ApoB were gradually increased according to tertiles of serum Co concentration (all P trend < 0.001). The risk of dyslipidemia was positively correlated with serum Co (OR = 3.500; 95% CI 1.630 ~ 7.517). Moreover, the levels of TNF-α and 8-iso-PGF2α were gradually risen in parallel with elevating serum Co. The elevation of TNF-α and 8-iso-PGF2α partially mediated Co-caused elevation of TC and LDL-C. Environmental Co exposure is associated with elevated lipid profile levels and dyslipidemia risk among elderly population. Systemic inflammation and lipid peroxidation partially mediate the associations of serum Co with dyslipidemia.
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Funding
This work was supported by National Natural Science Foundation of China (82100078), Natural Science Foundation of the Anhui Higher Education Institutions of China (2020ZR1292B002) and Scientific Research of Health Commission in Anhui Province (AHWJ2021b094).
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Jia-Hui Huang: conceptualization, methodology, investigation, writing — original draft, visualization, supervision, and funding acquisition. Li Tao: conceptualization, methodology, and resources. Yi Wu: methodology, software, and data curation. Wei He: methodology, software, and data curation. Jun-Xian Wang: methodology, software, data curation, resources, and project administration. Xi Chen: conceptualization, validation, formal analysis, investigation, writing — review and editing, visualization, and project administration. Lin Fu: conceptualization, validation, investigation, writing — review and editing, visualization, project administration, and funding acquisition. All the authors contributed to the development of the manuscript, read, and approved the final manuscript.
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Huang, JH., Tao, L., Wu, Y. et al. Cobalt exposure and dyslipidemia in elderly population: the mediating role of systemic inflammation and lipid peroxidation. Environ Sci Pollut Res 30, 50402–50411 (2023). https://doi.org/10.1007/s11356-023-25910-z
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DOI: https://doi.org/10.1007/s11356-023-25910-z