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The antioxidant effects of coenzyme Q10 on albino rat testicular toxicity and apoptosis triggered by bisphenol A

Environmental Science and Pollution Research (2023)Cite this article

Abstract 

Polycarbonate plastics for packaging and epoxy resins are both made with the industrial chemical bisphenol A (BPA). This investigation looked at the histological structure, antioxidant enzymes, and albino rats’ testis to determine how coenzyme Q10 (CoQ10) impacts BPA toxicity. For the experiments, three sets of 18 male adult rats were created: group 1 received no therapy, group 2 acquired BPA, and group 3 got the daily BPA treatment accompanied by coenzyme Q10, 1 h apart. The experimental period ran for 14 days. The biochemical biomarkers catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) were altered as a result of BPA exposure. The testicular histological architecture, which is made up of apoptosis, was also exaggerated. Furthermore, rats given BPA and CoQ10 treatment may experience a diminution in these negative BPA effects. These protective properties of CoQ10 may be correlated with the ability to eliminate oxidizing substances that can harm living species. The outcomes might support the hypothesis that CoQ10 prevented oxidative damage and boosted rats’ stress responses when BPA was introduced. Thus, by shielding mammals from oxidative stress, CoQ10 aids in the growth and development of the animals. BPA is extremely hazardous to humans and can persist in tissues. Human reproductive functions are a worry due to human exposure to BPA, especially for occupational workers who are typically exposed to higher doses of BPA. As a result, in order to reduce the health risks, BPA usage must be minimized across a diverse range of industries, and improper plastic container handling must be prohibited. By giving CoQ10 to patients, BPA’s harmful effects on reproductive structures and functions may be avoided.

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Data availability

Data presented in this study are available upon reasonable request from the corresponding author.

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Acknowledgements

The authors extend their appreciation to the College of Medicine for their assistance in the current study.

Funding

The authors received funding from the Deanship of Scientific Research at King Khalid University for this work (Grant No. G.R.P/189/43).

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, King Khalid University, P.O. 641, Abha, Saudi Arabia

    Refaat A. Eid

  2. Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia

    Alsaleem Mohammed Abadi

  3. Department of Biology, College of Science, King Khalid University, Abha, 61421, Saudi Arabia

    Attalla F. El-Kott

  4. Department of Zoology, College of Science, Damanhour University, Damanhour, 22511, Egypt

    Attalla F. El-Kott

  5. Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia

    Mohamed Samir A. Zaki

  6. Department of Histology and Cell Biology, College of Medicine, Zagazig University, Zagazig, Egypt

    Mohamed Samir A. Zaki

  7. Department of Zoology, College of Science, Fayoum University, Fayoum, Egypt

    Eman M. Abd-Ella

  8. Department of Biology, College of Science and Art, Al-Baha University, Al-Mandaq, Al-Baha, Saudi Arabia

    Eman M. Abd-Ella

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  1. Refaat A. Eid
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Contributions

Conceptualization, R. A. E. and M. S. A. Z.; methodology, R. A. E., E. M. A. and M. S. A. Z.; software, A. M. A.; validation, M. S. A. Z., A. F. E, and R. A. E.; formal analysis, A. F. E. and A. M. A.; investigation, R. A. E., E. M. A.; resources, A. F. E.; data curation, A. M. A.; E. M. A., A. F. E and M. S. A. Z.; writing—original draft preparation, M. S. A. Z., E. M. A., and R. A. E.; writing—review and editing, M. S. A. Z. and R. A. E.; visualization, M. S. A. Z.; supervision, R. A. E.; project administration, R. A. E. and A. M. A.; funding acquisition, A. M. A. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Refaat A. Eid.

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All animal studies followed King Khalid University’s College of Medicine’s rules for using animals in scientific research. These recommendations are based on international guidelines created by the National Institutes of Health for the care and use of laboratory animals (NIH Publications No. 8023, revised 1978).

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Eid, R.A., Abadi, A.M., El-Kott, A.F. et al. The antioxidant effects of coenzyme Q10 on albino rat testicular toxicity and apoptosis triggered by bisphenol A. Environ Sci Pollut Res (2023). https://doi.org/10.1007/s11356-022-24920-7

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Keywords

  • Bisphenol A
  • CoQ10
  • Testis
  • Biochemical markers
  • Light microscopy
  • Ultrastructure
  • Statistics