Abstract
Fipronil is a broad potent insecticide that belongs to the phenylpyrazole chemical family. Its action mode acting in the presynaptic and postsynaptic blocking the chlorine ions by the neurotransmitters GABA. It is considered highly toxic, and in some countries, its use has been prohibited. The objective of this review is to perform a scientometric analysis for global measurement of the research on the insecticide fipronil. All information in this study was searched in the Web of Science (WoS) database in December 2021. The search was carried using the term “fipronil.” Thus, 2362 studies were selected. Most selected articles showed toxicity effects of fipronil on non-target organisms, analytical methods to detect the insecticide, environmental degradation processes, and efficiency in reducing insects through its use. The H index for this dataset was 91. The cooperation network of the authors among countries showed the USA as the most notorious, with 30.6% of studies, followed by China (15.7%) and Brazil (10.9%). There are many studies on the toxicity of fipronil in bees, forms of degradation, and effectiveness of this insecticide. The present work presents suggestions pointed out in the articles for further research and highlights the importance of studies involving fipronil, as well as studies of alternative pest control.
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Data availability
All data supporting this study are extracted from published papers and are available from the corresponding author on reasonable request.
References
Aliouane Y, el Hassani AK, Gary V, Armengaud C, Lambin M, Gauthier M (2009) Subchronic exposure of honeybees to sublethal doses of pesticides: effects on behavior. Environ Toxicol Chem 28:113–122. https://doi.org/10.1897/08-110.1
Aria M, Cuccurullo C (2017) bibliometrix: an R-tool for comprehensive science mapping analysis. J Informet 11:959–975. https://doi.org/10.1016/j.joi.2017.08.007
Awad MA, Ahmed ZSO, AbuBakr HO, Elbargeesy G, Moussa MHG (2021a) Oxidative stress, apoptosis and histopathological alterations in brain stem and diencephalon induced by subacute exposure to fipronil in albino rats. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-021-15537-3
Awad MA, Ahmed ZSO, AbuBakr HO, Elbargeesy G, Moussa MHG (2021b) Fipronil induced oxidative stress in neural tissue of albino rat with subsequent apoptosis and tissue reactivity. Acta Histochem 123. https://doi.org/10.1016/j.acthis.2021b.151764
Azam A, Ahmed A, Wang H, Wang YE, Zhang ZT (2021) Knowledge structure and research progress in wind power generation (WPG) from 2005 to 2020 using CiteSpace based scientometric analysis. J Clean Prod 295. https://doi.org/10.1016/j.jclepro.2021.126496
Bloomquist JR (2003) Ion channels as targets for insecticides. Ann Rev Entomol 41:163–190, <Go to WoS>://WOS:000680791700014
Bobé A, Meallier P, Cooper J-F, Coste CM (1998) Kinetics and mechanisms of abiotic degradation of fipronil (hydrolysis and photolysis). J Agric Food Chem 46:2834–2839
Bobe A, Meallier P, Cooper JF, Coste CM (1998) Kinetics and mechanisms of abiotic degradation of fipronil (hydrolysis and photolysis). J Agric Food Chem 46:2834–2839. https://doi.org/10.1021/jf970874d
Bonmatin JM, Giorio C, Girolami V, Goulson D, Kreutzweiser DP, Krupke C, Liess M, Long E, Marzaro M, Mitchell EAD, Noome DA, Simon-Delso N, Tapparo A (2015) Environmental fate and exposure; neonicotinoids and fipronil. Environ Sci Pollut Res 22:35–67. https://doi.org/10.1007/s11356-014-3332-7
Bovi TS, Zaluski R, Orsi RO (2018) Toxicity and motor changes in Africanized honey bees (Apis mellifera L.) exposed to fipronil and imidacloprid. An Acad Bras Ciencias 90:239–245. https://doi.org/10.1590/0001-3765201820150191
Buckingham SD, Biggin PC, Sattelle BM, Brown LA, Sattelle DB (2005) Insect GABA receptors: Splicing, editing, and targeting by antiparasitics and insecticides. Mol Pharmacol 68:942–951. https://doi.org/10.1124/mol.105.015313
Cappelini LTD, Alberice JV, Eugenio PFM, Pozzi E, Urbaczek AC, Diniz LGR, Carrilho E, Carrilho E, Vieira EM (2018) Burkholderia thailandensis: the main bacteria biodegrading fipronil in fertilized soil with assessment by a QuEChERS/GC-MS method. J Braz Chem Soc 29: 1934–1943. https://doi.org/10.21577/0103-5053.20180069
Casida JE, Durkin KA (2013) Neuroactive insecticides: targets, selectivity, resistance, and secondary effects. Ann Rev Entomol 58(58):99–117. https://doi.org/10.1146/annurev-ento-120811-153645
Castilhos D, Bergamo GC, Gramacho KP, Goncalves LS (2019) Bee colony losses in Brazil: a 5-year online survey. Apidologie 50:263–272. https://doi.org/10.1007/s13592-019-00642-7
Chagnon M, Kreutzweiser D, Mitchell EA, Morrissey CA, Noome DA, Van der Sluijs JP (2015) Risks of large-scale use of systemic insecticides to ecosystem functioning and services. Environ Sci Pollut Res 22:119–134. https://doi.org/10.1007/s11356-014-3277-x
Chauzat MP, Faucon JP, Martel AC, Lachaize J, Cougoule N, Aubert M (2006) A survey of pesticide residues in pollen loads collected by honey bees in France. J Econ Entomol 99:253–262, <Go to ISI>://WOS:000236813800001
Chen C (2014) The CiteSpace Manual. Coll Comput Inform 1:1–84
Chen CM, Hu ZG, Liu SB, Tseng H (2012) Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace. Expert Opin Biol Ther 12:593–608. https://doi.org/10.1517/14712598.2012.674507
Chen C (2020) How to Use CiteSpace. 2015–2020
Cochran RC, Yu L, Krieger RI, Ross JH (2015) Postapplication fipronil exposure following use on pets. J Toxicol Environ Health A 78:1217–1226. https://doi.org/10.1080/15287394.2015.1076363
de Morais CR, Travencolo BAN, Carvalho SM, Beletti ME, Santos VSV, Campos CF, de Campos EO, Pereira BB, Naves MPC, de Rezende AAA, Spano MA, Vieira CU, Bonetti AM (2018) Ecotoxicological effects of the insecticide fipronil in Brazilian native stingless bees Melipona scutellaris (Apidae: Meliponini). Chemosphere 206:632–642. https://doi.org/10.1016/j.chemosphere.2018.04.153
Decourtye A, Devillers J, Genecque E, Le Menach K, Budzinski H, Cluzeau S, Pham-Delegue MH (2005) Comparative sublethal toxicity of nine pesticides on olfactory learning performances of the honeybee Apis mellifera. Arch Environ Contam Toxicol 48:242–250. https://doi.org/10.1007/s00244-003-0262-7
Deiu AS, Ondarza PM, Miglioranza KSB, de la Torre FR (2021) Multibiomarker responses and bioaccumulation of fipronil in Prochilodus lineatus exposed to spiked sediments: Oxidative stress and antioxidant defenses. Pestic Biochem Physiol 177. https://doi.org/10.1016/j.pestbp.2021.104876
Eadie A, Vasquez IC, Liang XF, Wang XH, Souders CL, El Chehouri J, Hoskote R, Feswick A, Cowie AM, Loughery JR, Martyniuk CJ (2020) Residual molecular and behavioral effects of the phenylpyrazole pesticide fipronil in larval zebrafish (Danio rerio) following a pulse embryonic exposure. Comp Biochem Physiol Part D Genomics Proteomics 36. https://doi.org/10.1016/j.cbd.2020.100743
FAO FaAO (2019) Pesticides use
Ffrench-Constant RH, Williamson MS, Davies TGE, Bass C (2016) Ion channels as insecticide targets. J Neurogenet 30:163–177. https://doi.org/10.1080/01677063.2016.1229781
Gant DB, Chalmers AE, Wolff MA, Hoffman HB, Bushey DF (1998) Fipronil: action at the GABA receptor. Pesticides and the duture: minimizing chronic exposure of humans and the environment. 147–156, <Go to ISI>://WOS:000076756800014
Ghisi ND, Zuanazzi NR, Fabrin TMC, Oliveira EC (2020) Glyphosate and its toxicology: a scientometric review. Sci Total Environ 733:15. https://doi.org/10.1016/j.scitotenv.2020.139359
Gibbons D, Morrissey C, Mineau P (2015) A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife. Environ Sci Pollut Res 22:103–118. https://doi.org/10.1007/s11356-014-3180-5
Gripp HS, Freitas JS, Almeida EA, Bisinoti MC, Moreira AB (2017) Biochemical effects of fipronil and its metabolites on lipid peroxidation and enzymatic antioxidant defense in tadpoles (Eupemphix nattereri: Leiuperidae). Ecotoxicol Environ Saf 136:173–179. https://doi.org/10.1016/j.ecoenv.2016.10.027
Gunasekara AS, Truong T, Goh KS, Spurlock F, Tjeerdema RS (2007) Environmental fate and toxicology of fipronil. J Pestic Sci 32:189–199. https://doi.org/10.1584/jpestics.R07-02
Gupta RC, Anadón A (2018) Fipronil, Veterinary toxicology. Elsevier, pp. 533–538
Hainzl D, Casida JE (1996) Fipronil insecticide: novel photochemical desulfinylation with retention of neurotoxicity. Proc Natl Acad Sci USA 93:12764–12767. https://doi.org/10.1073/pnas.93.23.12764
Hainzl D, Cole LM, Casida JE (1998) Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct. Chem Res Toxicol 11:1529–1535. https://doi.org/10.1021/tx980157t
Hirsch JE (2005) An index to quantify an individual’s scientific research output. Proc Natl Acad Sci USA 102:16569–16572. https://doi.org/10.1073/pnas.0507655102
Holder PJ, Jones A, Tyler CR, Cresswell JE (2018) Fipronil pesticide as a suspect in historical mass mortalities of honey bees. Proc Natl Acad Sci USA 115:13033–13038. https://doi.org/10.1073/pnas.1804934115
Kucukguzel SG, Senkardes S (2015) Recent advances in bioactive pyrazoles. Eur J Med Chem 97:786–815. https://doi.org/10.1016/j.ejmech.2014.11.059
Li MH, Li PY, Wang L, Feng MY, Han LJ (2015) Determination and Dissipation of Fipronil and Its Metabolites in Peanut and Soil. J Agric Food Chem 63:4435–4443. https://doi.org/10.1021/jf5054589
Li XJ, Li HM, Ma W, Guo Z, Li XQ, Song SJ, Tang H, Li XM, Zhang QH (2019) Development of precise GC-EI-MS method to determine the residual fipronil and its metabolites in chicken egg. Food Chem 281:85–90. https://doi.org/10.1016/j.foodchem.2018.12.041
Liu W (2019) The data source of this study is Web of Science Core Collection? Not enough. Scientometrics 121:1815–1824
Liu Y, Zhao EC, Zhu WT, Gao HX, Zhou ZQ (2009) Determination of four heterocyclic insecticides by ionic liquid dispersive liquid-liquid microextraction in water samples. J Chromatogr A 1216:885–891. https://doi.org/10.1016/j.chroma.2008.11.076
Mota-Sanchez D, Wise JC (2019) The arthropod pesticide resistance database. Michigan State University, Michigan State University
Mullin CA, Frazier M, Frazier JL, Ashcraft S, Simonds R, vanEngelsdorp D, Pettis JS (2010) High levels of miticides and agrochemicals in North American apiaries: implications for honey bee health. PLoS ONE 5. https://doi.org/10.1371/journal.pone.0009754
Munoz-Capponi EA, Silva-Aguayo G, Rodriguez-Maciel JC, Rondanelli-Reyes MJ (2018) Sublethal exposure to fipronil affects the morphology and development of honey bees, Apis mellifera. Bull Insectol 71: 121–130, <Go to ISI>://WOS:000430811100016
Nunes A, Schmitz C, Moura S, Maraschin M (2021) The influence of recent Brazilian policy and legislation on increasing bee mortality. Res Soc Dev 10:e36910414157–e36910414157
Oliveira Filho LCI, Baretta D (2016) Por que devemos nos importar com os colêmbolos edáficos? Sci Agrar 17:21–40
PAN (2022): Pesticide Action Network
Pires CSS, Pereira FdM, Lopes MTdR, Nocelli RCF, Malaspina O, Pettis JS, Teixeira ÉW (2016) Enfraquecimento e perda de colônias de abelhas no Brasil: há casos de CCD? Pesq Agrop Brasileira 51:422–442
Pisa LW, Amaral-Rogers V, Belzunces LP, Bonmatin JM, Downs CA, Goulson D, Kreutzweiser DP, Krupke C, Liess M, McField M, Morrissey CA, Noome DA, Settele J, Simon-Delso N, Stark JD, Van der Sluijs JP, Van Dyck H, Wiemers M (2015) Effects of neonicotinoids and fipronil on non-target invertebrates. Environ Sci Pollut Res 22:68–102. https://doi.org/10.1007/s11356-014-3471-x
Qin FL, Zhu Y, Ao TQ, Chen T (2021) The development trend and research frontiers of distributed hydrological models-visual bibliometric analysis based on CiteSpace. Water 13. https://doi.org/10.3390/w13020174
Reich H, Triacchini GA, European Food Safety A (2018) Occurrence of residues of fipronil and other acaricides in chicken eggs and poultry muscle/fat. EFSA J 16. https://doi.org/10.2903/j.efsa.2018.5164
Saka M, Tada N (2021) Acute and chronic toxicity tests of systemic insecticides, four neonicotinoids and fipronil, using the tadpoles of the western clawed frog Silurana tropicalis. Chemosphere 270. https://doi.org/10.1016/j.chemosphere.2020.129418
Sanchez-Bayo F, Goulson D, Pennacchio F, Nazzi F, Goka K, Desneux N (2016) Are bee diseases linked to pesticides? — a brief review. Environ Int 89–90:7–11. https://doi.org/10.1016/j.envint.2016.01.009
Schaaf AA (2015) Valoración de impacto ambiental por pesticidas agrícolas. Obs Medioambiental 18:87
Seydi E, Mehrpouya L, Sadeghi H, Rahimi S, Pourahmad J (2019) Toxicity of fipronil on rat heart mitochondria. Toxin Rev 40:1338–1346. https://doi.org/10.1080/15569543.2019.1700382
Seydi E, Mehrpouya L, Sadeghi H, Rahimi S, Pourahmad J (2021) Luteolin attenuates Fipronil-induced neurotoxicity through reduction of the ROS-mediated oxidative stress in rat brain mitochondria. Pestic Biochem Physiol 173. https://doi.org/10.1016/j.pestbp.2021.104785
Sgolastra F, Medrzycki P, Bortolotti L, Maini S, Porrini C, Simon-Delso N, Bosch J (2020) Bees and pesticide regulation: lessons from the neonicotinoid experience. Biol Cons 241. https://doi.org/10.1016/j.biocon.2019.108356
Shakya M, Kumar S, Fular A, Upadhaya D, Sharma AK, Bisht N, Nandi A, Ghosh S (2020) Emergence of fipronil resistant Rhipicephalus microplus populations in Indian states. Exp Appl Acarol 80:591–602. https://doi.org/10.1007/s10493-020-00481-7
Simon-Delso N et al (2015) Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites. Environ Sci Pollut Res 22:5–34. https://doi.org/10.1007/s11356-014-3470-y
Stork NE (2018) How Many species of insects and other terrestrial arthropods are there on Earth? Annu Rev Entomol 63(63):31–45. https://doi.org/10.1146/annurev-ento-020117-043348
Tingle CCD, Rother JA, Dewhurst CF, Lauer S, King WJ (2003) Fipronil: environmental fate, ecotoxicology, and human health concerns. Rev Environ Contam Toxicol 176:1–66, <Go to ISI>://WOS:000179880300001
Tomazini R, Saia FT, van der Zaan B, Grosseli GM, Fadini PS, de Oliveira RGM, Gregoracci GB, Mozetto A, van Vugt-Lussenburg BMA, Brouwer A, Langenhoff AAM (2021) Biodegradation of fipronil: transformation products, microbial characterisation and toxicity assessment. Water Air Soil Pollut 232. https://doi.org/10.1007/s11270-021-05071-w
Ucar A, Parlak V, Ozgeris FB, Yeltekin AC, Alak G, Atamanalp M (2020) Determination of fipronil toxicity by different biomarkers in gill and liver tissue of rainbow trout (Oncorhynchus mykiss). In Vitro Cell Dev Biol-Anim 56:543–549. https://doi.org/10.1007/s11626-020-00480-3
Vidau C, Diogon M, Aufauvre J, Fontbonne R, Vigues B, Brunet JL, Texier C, Biron DG, Blot N, El Alaoui H, Belzunces LP, Delbac F (2011) Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae. PLoS ONE 6. https://doi.org/10.1371/journal.pone.0021550
Wazir S, Shad SA (2022) Development of fipronil resistance, fitness cost, cross-resistance to other insecticides, stability, and risk assessment in Oxycarenus hyalinipennis (Costa). Sci Total Environ 803. https://doi.org/10.1016/j.scitotenv.2021.150026
Wei GY (2019) A bibliometric analysis of the top five economics journals during 2012–2016. J Econ Surv 33:25–59. https://doi.org/10.1111/joes.12260
Weidinger A, Kozlov AV (2015) Biological activities of reactive oxygen and nitrogen species: oxidative stress versus signal transduction. Biomolecules 5:472–484. https://doi.org/10.3390/biom5020472
Weston DP, Lydy MJ (2014) Toxicity of the Insecticide fipronil and its degradates to benthic macroinvertebrates of urban streams. Environ Sci Technol 48:1290–1297. https://doi.org/10.1021/es4045874
Wilson TG (2001) Resistance of Drosophila to toxins. Annu Rev Entomol 46:545–571. https://doi.org/10.1146/annurev.ento.46.1.545
Yu DJ, Xu ZS, Pedrycz W, Wang WR (2017) Information sciences 1968–2016: a retrospective analysis with text mining and bibliometric. Inf Sci 418:619–634. https://doi.org/10.1016/j.ins.2017.08.031
Zhang Y, Li C, Ji XH, Yun CL, Wang ML, Luo XG (2020) The knowledge domain and emerging trends in phytoremediation: a scientometric analysis with CiteSpace. Environ Sci Pollut Res 27:15515–15536. https://doi.org/10.1007/s11356-020-07646-2
Acknowledgements
The authors thank the Coordination for the Improvement of Higher Education Personnel (CAPES) — Brazil, the National Council for Scientific and Technological Development (CNPq — National Council for Scientific and Technological Development) — Brazil, and the Federal Technological University of Paraná (UTFPR) and to Fernanda Moreira Delavy. The authors would like to thank the Multiuser Core Laboratory of Biological Analysis and Molecular Biology (BioMol) at Universidade Tecnológica Federal do Paraná (UTFPR), Campus Dois Vizinhos.
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The access to data bases was funded by Brazilian government — Coordination for the Improvement of Higher Education Personnel (CAPES).
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Sandrieli Gonçalves: data curation; formal analysis; investigation; methodology; resources; software; visualization; writing — original draft. Marina W. Vasconcelos: data curation; formal analysis; investigation; methodology; resources; software; validation; visualization; writing — original draft. Thais Fernandes Mendonça Motta: supervision; writing — review and editing. Juliana Marceli Hofma Lopes: data curation, visualization, writing — review and editing. Larissa Juliane Guimaraes: data curation, visualization, writing — original draft. Karina S.B. Miglioranza: supervision; writing — review and editing. Nédia C. Ghisi: conceptualization; methodology, project administration; resources; funding acquisition; supervision; writing — review and editing. All authors read and approved the final manuscript.
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Gonçalves, S., Vasconcelos, M.W., Mota, T.F.M. et al. Identifying global trends and gaps in research on pesticide fipronil: a scientometric review. Environ Sci Pollut Res 29, 79111–79125 (2022). https://doi.org/10.1007/s11356-022-21135-8
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DOI: https://doi.org/10.1007/s11356-022-21135-8