Abstract
The influence of tobacco smoke has been a controversial and very questionable subject within the field of neurological behaviours. To examine the dose–response relationships between tobacco smoke and neurological performance, we investigated whether mitochondrial DNA copy number (mtDNAcn) mediates these relationships. We used restricted cubic spline models to estimate the dose–response relationships. A mediation model was also used to detect the mediating effect. Increased cotinine was negatively associated with auditory memory scores and a 0.51 decrease in mtDNAcn. MtDNAcn acts as a mediator between cotinine and auditory memory. Tobacco smoke levels were inversely associated with mtDNAcn and neurobehavioural changes, and there was a mediation effect between cotinine levels and auditory memory by mtDNAcn.
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Data availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- AD:
-
Alzheimer’s disease
- 3HC:
-
Trans-3-Hydroxycotinine
- mtDNAcn:
-
Mitochondrial DNA copy number
- POMSA:
-
Anger-hostility
- POMSC:
-
Confusion-bewilderment
- POMSD:
-
Depression-dejection
- POMSF:
-
Fatigue-inertia
- POMST:
-
Tension-anxiety
- POMSV:
-
Vigor-activity
- DSP:
-
Total digit span
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Funding
This study was funded by the National Natural Science Foundation of China (81673143, 81072279, and 30800899), Shanxi Province Natural Science Foundation (2010021034–3 and 2015011128), and the Research Project Supported by Shanxi Scholarship Council (2016–057).
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Huimin Wang: writing—original draft, methodology, formal analysis, writing—review and editing. Mengmeng Fu: writing—original draft, methodology, formal analysis, writing—review and editing. Yifei Ma: project administration, writing—review and editing. Chengjuan Liu: investigation, data curation, resources, writing—review and editing. Min Wu: investigation, writing—review and editing. Jisheng Nie: funding acquisition, conceptualization, supervision, project administration, writing—review and editing.
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Wang, H., Fu, M., Ma, Y. et al. Tobacco smoke exposure and mitochondrial DNA copy number on neurobehavioural performance: A community study. Environ Sci Pollut Res 29, 84180–84190 (2022). https://doi.org/10.1007/s11356-022-20921-8
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DOI: https://doi.org/10.1007/s11356-022-20921-8