Abstract
The enantioselective behaviors of chiral pesticides would affect the accuracy of risk assessment. This study evaluated the enantioselectivity of chiral triticonazole (a widely used fungicide) in three kinds of fruits. Firstly, the enantioseparation of triticonazole enantiomers was carried out within 1.2 min utilizing CHIRALPAK OJ-3 column with a mixture of CO2 and methanol (93:7, v/v) using SFC-MS/MS. Secondly, field trials were conducted to clarify the enantioselective degradation and residue of S-( +)-triticonazole and R-(–)-triticonazole in fruits. The initial concentrations of rac-triticonazole were 25.1–93.1 ng/g, and enantioselective degradation was observed in pear, peach, and jujube after 2 h, 10 days, and 3 days, respectively. The degradation of S-( +)-triticonazole was fastest in pear (T1/2, 2.01 days), while the T1/2 of R-(–)-triticonazole was 5.02 days. The residue concentrations of rac-triticonazole were less than the MRL set by EU (10 ng/g) on the 3rd and 21st day in pear and peach, respectively, which were lower than 10 ng/g in jujube on the 30th day (no MRL). Finally, we found that the dietary intake risks of rac-triticonazole in fruits were low for 2–7 age, 20–50 age/female, and 20–50 age/male. The current study could provide complimentary references for the rational usage, MRL formulation, and risk assessment of chiral triticonazole.
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Funding
This study was supported by the Science Technology Project of Zhejiang Province [Grant No. 2020C02023], the National Natural Science Foundation of China [Grant No. 22006137], the Natural Science Foundation of Zhejiang Province [Grant No. LQ21C140002], the National Key Research and Development Program of China [Grant No. 2018YFC1603004], and the project of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products [grant numbers 2010DS700124-ZZ2001 and 2010DS700124-ZZ2009].
Science Technology Project of Zhejiang Province,2020C02023,Xinquan Wang,National Natural Scinence Foundation of China,22006137,Shanshan Di,Natural Science Foundation of Zhejiang Province,LQ21C140002,Shanshan Di,National Key Research and Development Program of China,2018YFC1603004,Yanhua Wang,project of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,2010DS700124-ZZ2001,Xinquan Wang,201DS700124-ZZ2009,Peipei Qi
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Investigation: Chao Guo, Shanshan Di; writing – original draft: Chao Guo, Shanshan Di; visualization: Chao Guo; conceptualization: Xiaolong Chen; validation: Yanhua Wang; data curation: Peipei Qi; resources: Zhiwei Wang; supervision: Huiyu Zhao; formal analysis: Yuanlin Gu; funding acquisition; Hao Xu: writing – review and editing: Yuele Lu; project administration, writing – review and editing: Xinquan Wang.
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Guo, C., Di, S., Chen, X. et al. Evaluation of chiral triticonazole in three kinds of fruits: enantioseparation, degradation, and dietary risk assessment. Environ Sci Pollut Res 29, 32855–32866 (2022). https://doi.org/10.1007/s11356-021-17896-3
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DOI: https://doi.org/10.1007/s11356-021-17896-3