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The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis

Abstract

We performed a systematic and meta-analysis study to find the association between cadmium (Cd) exposure and blood pressure (BP)/hypertension (HTN) in exposed general populations. We searched main databases for literature published between year 2000 and April 15, 2021. Quality assessment was performed with the Joanna Briggs Institute (JBI) critical appraisal tools. Heterogeneity between studies was determined by I-squared (I2) statistic. The random effects model was used to determine the association between blood and urine Cd levels with hypertension. The overall standard differences in mean for Cd level in hypertensive and control groups were 3.34, 1.79, and 8.09 based on samples from blood, urine, and hair, respectively. The overall standard differences in mean for Cd level in the low and high exposure groups were − 0.795 and − 1.036 based on blood and urinary samples, respectively. Our findings indicate a positive relationship between blood and hair Cd levels and hypertension. We also found that hair is the optimal biological sample to find the relationship between Cd exposure and hypertension for both genders. However, more studies are needed to confirm these findings.

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Abbreviations

Cd:

Cadmium

BP:

Blood pressure

HTN:

Hypertension

JBI:

The Joanna Briggs Institute

ATSDR:

The Agency for Toxic Substances and Disease Registry

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

BCd:

Blood cadmium

UCd:

Urine cadmium

HCd:

Hair cadmium

TCd:

Toenail cadmium

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

SDM:

Standard difference in means

SE:

Standard error

CI:

Confidence interval

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TF and SS involved in the conceptualization, validation of resources, and data extraction. HA, MAZ, TF, AF, AN (Abolfazl Naimabad), and SS performed the writing of the manuscript, SS, AN (Ali Naghizadeh), and MA reviewed and edited the manuscript. All of the authors read and approved the final manuscript.

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Correspondence to Saeed Samarghandian.

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Aramjoo, H., Arab-Zozani, M., Feyzi, A. et al. The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis. Environ Sci Pollut Res 29, 35682–35706 (2022). https://doi.org/10.1007/s11356-021-17777-9

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Keywords

  • Blood pressure
  • Cadmium
  • Environmental exposure
  • High blood pressure
  • Hypertension
  • Meta-analysis