Abstract
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine disruptor. DEHP can be absorbed into the human body through the air, food, water, and skin. After entering the human body, DEHP is rapidly converted to mono(2-ethylhexyl) phthalate (MEHP) with greater toxicity than DEHP. An increasing number of studies indicates that DEHP or MEHP can damage the thyroid tissue and disrupt the function, but the mechanisms remain unclear. This article reviews the toxicity of DEHP on thyroid structures and functions and summarizes the potential mechanisms to provide evidence for preventing the thyroid-related diseases.
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This study was supported by the National Natural Science Foundation of China (Grant No. 81972996, 81573184).
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XZ and WQ conducted the articles’ collection and drafted the manuscript. QX, XL, and LZ contributed to discussion and revision. LY is the corresponding author for this article. All authors read and approved the final manuscript.
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Zhang, X., Qi, W., Xu, Q. et al. Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications. Environ Sci Pollut Res 29, 1634–1644 (2022). https://doi.org/10.1007/s11356-021-17027-y
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DOI: https://doi.org/10.1007/s11356-021-17027-y