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Larvicidal and repellent activity of N-methyl-1-adamantylamine and oleic acid a major derivative of bael tree ethanol leaf extracts against dengue mosquito vector and their biosafety on natural predator

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Abstract

Aegle marmelos (L.) Correa belongs to the family Rutaceae is generally known as “bael fruit tree” occuring across the south Asian countries. The current investigation screened the main derivatives from crude ethanolic extracts of the Bael tree leaf and evaluated activity effects on the larvae and adults of Aedes aegypti (L.) Dengue vector mosquito and a non-target aquatic predator. The GC-MS results showed that the peak area was found to be profound in N-methyl-1-adamantaneacetamide (N-M 1a) followed by oleic acid (OA) with 63.08 and 11.43% respectively. The larvicidal activity against the fourth instar larvae and the crude Ex-Am showed prominent mortality rate (93.60%) at the maximum dosage of 100 ppm. The mortality rate of N-M 1a and OA was occurred at 10 ppm (97.73%) and 12 ppm (95.4%). The repellent activity was found to be prominent at crude Ex-Am (50 ppm) as compared to the pure compounds (N-m 1a and OA) with maximum protection time up to 210 min. The non-target screening of Ex-Am, N-M 1a, and OA on mosquito predator Tx. splendens showed that they are scarcely toxic even at the maximum dosage of 1000 ppm (34.13%), 100 ppm (27.3%), and 120 ppm (31.3%) respectively. Thus, the present investigation clearly proved that the crude Ex-Am and their major derivatives Nm 1-a and OA showed their acute larval toxicity as well as potential mosquito repellent against the dengue mosquito and eco-safety against the mosquito predator.

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Data availability

The data generated in the current study are available from the corresponding author on request.

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Acknowledgements

M. C. was supported by the Department of Science and Technology, Science and Engineering Research Board (SERB), Government of India (File No. PDF/2016/001185). The authors also extend their appreciation to the researchers supporting project number (RSP-2021/190), King Saud University, Riyadh, Saudi Arabia.

Funding

This research was supported by the Department of Science and Technology, Science and Engineering Research Board (SERB), Government of India (File No. PDF/2016/001185). The authors also extend their appreciation to the Researchers supporting project number (RSP-2021/190), King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Tirunelveli, India

    Muthiah Chellappandian, Sengottayan Senthil-Nathan & Sengodan Karthi

  2. PG and Research Department of Botany, V.O. Chidambaram College, Thoothukudi, Tamil Nadu, 628 008, India

    Muthiah Chellappandian

  3. Department of Biotechnology, St. Peter’s Institute of Higher Education and Research, Chennai, India

    Prabhakaran Vasantha-Srinivasan

  4. Department of Zoology, Post Graduate and Research Centre, Sri Parasakthi College for Women, Tirunelveli, India

    Kandaswamy Kalaivani

  5. United States Department of Agriculture, Agricultural Research Service, U.S. Horticultural Research Laboratory, Fort Pierce, FL, USA

    Wayne Brian Hunter

  6. Department of Botany and Microbiology , College of Science, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia

    Ajmal M. Ali

  7. The Principal, V.O. Chidambaram College, Thoothukudi, Tamil Nadu, 628 008, India

    Chockalingam Veerabahu

  8. Department of Botany and Microbiology, College of Sciences, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia

    Mohamed Soliman Elshikh & Dunia A. Al Farraj

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  1. Muthiah Chellappandian
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  2. Sengottayan Senthil-Nathan
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Contributions

M. C. and S. S. conceived original project idea. M. C., S. K., and P. V. were involved in the collection of samples and experimental work. K. K., W. H., H. A., V. C., M. E., and D. F. prepared the draft copy. All the authors read and approved the final manuscript copy.

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Correspondence to Sengottayan Senthil-Nathan.

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All research performed was approved by the University AAALAC Institutional Animal Care and Use of Laboratory Animals, Committee, Animal Health, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Tirunelveli, India.

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Chellappandian, M., Senthil-Nathan, S., Karthi, S. et al. Larvicidal and repellent activity of N-methyl-1-adamantylamine and oleic acid a major derivative of bael tree ethanol leaf extracts against dengue mosquito vector and their biosafety on natural predator. Environ Sci Pollut Res 29, 15654–15663 (2022). https://doi.org/10.1007/s11356-021-16219-w

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