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Prenatal air pollution exposure increases the risk of macrosomia: evidence from a prospective cohort study in the coastal area of China

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Abstract

Effects of prenatal ambient air pollution exposure could increase the risk of adverse pregnancy outcomes, which have been well documented by various studies. However, only very few studies investigated the effects on macrosomia. This study investigated the effects of prenatal air pollution exposure on the risk of macrosomia in a coastal city of China. Data of birth outcomes and air pollution in a coastal city in China between November 1, 2013, and December 31, 2017, were collected. Finally, 58,713 eligible births, including 8159 (13.9%) macrosomia and 50554 (86.1%) normal birth weight (NBW) infants, were included in the analysis. Logistic regression analyses were used to evaluate the effects of prenatal air pollution exposure on macrosomia. In the single-pollutant models, each 10 μg/m3 increase of PM2.5, PM10, and SO2 exposures, during the entire pregnancy or three trimesters, were related to elevated risk of macrosomia (adjusted RR, 95% CI) ranging from 1.018 (1.001, 1.035) to 1.314 (1.188, 1.454). In addition, O3 exposure in the first trimester (adjusted RR =1.034, 95% CI 1.009, 1.059) also increased the macrosomia risk. Prenatal PM2.5, PM10, and SO2 exposure could significantly increase the risk of macrosomia. These findings need to be further verified in more studies with multiple coastal cities included.

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Acknowledgements

The authors wish to thank all the investigators in the YMXH system for their help and support of this study.

Funding

This research was supported by the Natural Science Foundation of Anhui Province (No. 2108085MH304), the Project Foundation for the Young Talents in Colleges of Anhui Province (No. gxyq2017003), the Grant for Scientific Research of BSKY from Anhui Medical University (No. XJ201621), the National Natural Science Foundation of China (No. 81872580), and the Student’s Platform for Innovation and Entrepreneurship Training Program of China (No. 201810366031).

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Authors and Affiliations

  1. Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China

    Changlian Li, Liangliang Ju, Mei Yang, Qi Zhang, Shu Sun, Jiyu Cao & Rui Ding

  2. Department of Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China

    Jiyu Cao

Authors
  1. Changlian Li
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  2. Liangliang Ju
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  3. Mei Yang
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  4. Qi Zhang
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  5. Shu Sun
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  6. Jiyu Cao
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  7. Rui Ding
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Contributions

Changlian Li: writing-original draft preparation, formal analysis, data curation. Liangliang Ju: formal analysis, methodology. Mei Yang: formal analysis, methodology. Shu Sun: software, investigation. Qi Zhang: software, investigation. Jiyu Cao: supervision, funding acquisition. Rui Ding: writing- reviewing and editing, conceptualization, project administration

Corresponding authors

Correspondence to Jiyu Cao or Rui Ding.

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Ethics approval and consent to participate

The study was approved by the Institutional Review Board of Anhui Medical University Ethics Committee. All the participants signed informed consents for themselves and their children.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Responsible Editor: Lotfi Aleya

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Li, C., Ju, L., Yang, M. et al. Prenatal air pollution exposure increases the risk of macrosomia: evidence from a prospective cohort study in the coastal area of China. Environ Sci Pollut Res 29, 5144–5152 (2022). https://doi.org/10.1007/s11356-021-16054-z

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