Abstract
Air pollution and its negative effects on health of people have been a global concern. Many studies had found a strong association between air pollutants and risk of death, but few had focused on the effects of six pollutants and rural areas. Our study aimed to investigate the effects of six air pollutants (CO, NO2, O3, PM2.5, PM10, and SO2) on non-accidental and respiratory deaths in rural areas of Anhui Province by adjusting for confounding factors, and to further clarify which populations were susceptible to death associated with air pollution. In the first phase of the analysis, the generalized additive models were combined with the distributed lag non-linear models to evaluate the individual effects of air pollution on death in each area. In the second stage, random-effects models were used to aggregate the associations between air pollutants and mortality risk in nine areas. Overall, six pollutants had the strongest effects on the risk of death on the lag 07 days. The associations between PM2.5 and NO2 and daily non-accidental deaths were strongest, with maximum RR (lag 07): 1.63 (1.37–1.88) and 1.67 (1.37–1.96). The maximum pooled effects of association between six air pollutants and RD were PM2.5, with RR (lag 07): 1.89 (1.45–2.34). PM2.5 and PM10 had significant differences between the elderly and the non-elderly with respectively, RRR: 1.22 (1.04–1.41) and 1.26 (1.11–1.42). In general, we found that six air pollutants were the important risk factors for deaths (deaths from respiratory disease and non-accidental) in rural areas of Anhui Province. PM10 and PM2.5 had a considerable impact on the elderly.
Similar content being viewed by others
Data availability
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
References
Altman DG, Bland JM (2003) Interaction revisited: the difference between two estimates. Br Med J 326:219–219. https://doi.org/10.1136/bmj.326.7382.219
Ambrose JA, Barua RS (2004) The pathophysiology of cigarette smoking and cardiovascular disease. J Am Coll Cardiol 43:1731–1737. https://doi.org/10.1016/j.jacc.2003.12.047
Amini H, Trang Nhung NT, Schindler C, Yunesian M, Hosseini V, Shamsipour M, Hassanvand MS, Mohammadi Y, Farzadfar F, Vicedo-Cabrera AM, Schwartz J, Henderson SB, Künzli N (2019) Short-term associations between daily mortality and ambient particulate matter, nitrogen dioxide, and the air quality index in a Middle Eastern megacity. Environ Pollut 254:113121. https://doi.org/10.1016/j.envpol.2019.113121
Atkinson RW, Kang S, Anderson HR, Mills IC, Walton HA (2014) Epidemiological time series studies of PM2.5 and daily mortality and hospital admissions: a systematic review and meta-analysis. Thorax. 69:660–665. https://doi.org/10.1136/thoraxjnl-2013-204492
Bell ML, Zanobetti A, Dominici F (2013) Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter: a systematic review and meta-analysis. Am J Epidemiol 178:865–876. https://doi.org/10.1093/aje/kwt090
Cakmak S, Dales RE, Rubio MA, Vidal CB (2011) The risk of dying on days of higher air pollution among the socially disadvantaged elderly. Environ Res 111:388–393. https://doi.org/10.1016/j.envres.2011.01.003
Chen J, Hoek G (2020) Long-term exposure to PM and all-cause and cause-specific mortality: a systematic review and meta-analysis. Environ Int 143:105974. https://doi.org/10.1016/j.envint.2020.105974
Chen R, Yin P, Meng X, Liu C, Wang L, Xu X, Ross JA, Tse LA, Zhao Z, Kan H, Zhou M (2017) Fine particulate air pollution and daily mortality. A Nationwide Analysis in 272 Chinese Cities. Am J Respir Crit Care Med 196:73–81. https://doi.org/10.1164/rccm.201609-1862OC
Chen Q, Wang Q, Xu B, Xu Y, Ding Z, Sun H (2021a) Air pollution and cardiovascular mortality in Nanjing, China: evidence highlighting the roles of cumulative exposure and mortality displacement. Chemosphere. 265:129035. https://doi.org/10.1016/j.chemosphere.2020.129035
Chen Z, Fu Q, Mao G, Wu L, Xu P, Xu D, Wang Z, Pan X, Chen Y, Lou X, Mo Z, Wang X, Feng Y (2021b) Increasing mortality caused by chronic obstructive pulmonary disease (COPD) in relation with exposure to ambient fine particulate matters: an analysis in Southeastern China. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-021-14009-y
Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS (2007) The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med 176:370–376. https://doi.org/10.1164/rccm.200611-1627OC
Chuang KJ, Yan YH, Cheng TJ (2010) Effect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach. J Occup Environ Med 52:258–262. https://doi.org/10.1097/jom.0b013e3181ceff7a
Cohen AJ, Brauer M, Burnett R, Anderson HR, Frostad J, Estep K, Balakrishnan K, Brunekreef B, Dandona L, Dandona R, Feigin V, Freedman G, Hubbell B, Jobling A, Kan H, Knibbs L, Liu Y, Martin R, Morawska L, Pope CA 3rd, Shin H, Straif K, Shaddick G, Thomas M, van Dingenen R, van Donkelaar A, Vos T, CJL M, Forouzanfar MH (2017) Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet 389:1907–1918. https://doi.org/10.1016/S0140-6736(17)30505-6
de Paula SU, Braga AL, Giorgi DM, Pereira LA, Grupi CJ, Lin CA, Bussacos MA, Zanetta DM, do Nascimento Saldiva PH, Filho MT (2005) Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of São Paulo, Brazil. Eur Heart J 26:193–200. https://doi.org/10.1093/eurheartj/ehi035
Di Q, Wang Y, Zanobetti A, Wang Y, Koutrakis P, Choirat C, Dominici F, Schwartz JD (2017) Air pollution and mortality in the Medicare population. N Engl J Med 376:2513–2522. https://doi.org/10.1056/NEJMoa1702747
Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE (1993) An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759. https://doi.org/10.1056/NEJM199312093292401
Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM (2006) Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA. 295:1127–1134. https://doi.org/10.1001/jama.295.10.1127
Duan Y, Liao Y, Li H, Yan S, Zhao Z, Yu S, Fu Y, Wang Z, Yin P, Cheng J, Jiang H (2019) Effect of changes in season and temperature on cardiovascular mortality associated with nitrogen dioxide air pollution in Shenzhen, China. Sci Total Environ 697:134051. https://doi.org/10.1016/j.scitotenv.2019.134051
Hoek G, Krishnan RM, Beelen R, Peters A, Ostro B, Brunekreef B, Kaufman JD (2013) Long-term air pollution exposure and cardio- respiratory mortality: a review. Environ Health 12:43. https://doi.org/10.1186/1476-069x-12-43
Huang Z, Lin H, Liu Y, Zhou M, Liu T, Xiao J, Zeng W, Li X, Zhang Y, Ebi KL, Tong S, Ma W, Wang L (2015) Individual-level and community-level effect modifiers of the temperature-mortality relationship in 66 Chinese communities. BMJ Open 5:e009172. https://doi.org/10.1136/bmjopen-2015-009172
Huang K, Ding K, Yang XJ, Hu CY, Jiang W, Hua XG, Liu J, Cao JY, Zhang T, Kan XH, Zhang XJ (2020) Association between short-term exposure to ambient air pollutants and the risk of tuberculosis outpatient visits: a time-series study in Hefei, China. Environ Res 184:109343. https://doi.org/10.1016/j.envres.2020.109343
Kinney PL (2018) Interactions of climate change, air pollution, and human health. Curr Environ Health Rep 5:179–186. https://doi.org/10.1007/s40572-018-0188-x
Li H, Chen R, Meng X, Zhao Z, Cai J, Wang C, Yang C, Kan H (2015) Short-term exposure to ambient air pollution and coronary heart disease mortality in 8 Chinese cities. Int J Cardiol 197:265–270. https://doi.org/10.1016/j.ijcard.2015.06.050
Li D, Wang JB, Zhang ZY, Shen P, Zheng PW, Jin MJ, Lu HC, Lin HB, Chen K (2018) Association between short-term exposure to ambient air pollution and daily mortality: a time-series study in Eastern China. Environ Sci Pollut Res 25:16135–16143. https://doi.org/10.1007/s11356-018-1759-y
Li B, Yang J, Dong H, Li M, Cai D, Yang Z, Zhang C, Wang H, Hu J, Bergmann S, Lin G, Wang B (2021) PM2.5 constituents and mortality from a spectrum of causes in Guangzhou, China. Ecotoxicol Environ Saf 222:112498. https://doi.org/10.1016/j.ecoenv.2021.112498
Lin H, Liu T, Xiao J, Zeng W, Li X, Guo L, Zhang Y, Xu Y, Tao J, Xian H, Syberg KM, Qian ZM, Ma W (2016) Mortality burden of ambient fine particulate air pollution in six Chinese cities: results from the Pearl River Delta study. Environ Int 96:91–97. https://doi.org/10.1016/j.envint.2016.09.007
Liu H, Tian Y, Xu Y, Huang Z, Huang C, Hu Y, Zhang J (2017) Association between ambient air pollution and hospitalization for ischemic and hemorrhagic stroke in China: a multicity case-crossover study. Environ Pollut 230:234–241. https://doi.org/10.1016/j.envpol.2017.06.057
Liu C, Yin P, Chen R, Meng X, Wang L, Niu Y, Lin Z, Liu Y, Liu J, Qi J, You J, Kan H, Zhou M (2018a) Ambient carbon monoxide and cardiovascular mortality: a nationwide time-series analysis in 272 cities in China. Lancet Planet Health 2:e12–e18. https://doi.org/10.1016/S2542-5196(17)30181-X
Liu W, Xu Z, Yang T (2018b) Health effects of air pollution in China. Int J Environ Res Public Health 15:1471. https://doi.org/10.3390/ijerph15071471
Liu Y, Zhao S, Li Y, Song W, Yu C, Gao L, Ran J, He D, Li H (2021) Effect of ambient air pollution on tuberculosis risks and mortality in Shandong, China: a multi-city modeling study of the short- and long-term effects of pollutants. Environ Sci Pollut Res Int 28:27757–27768. https://doi.org/10.1007/s11356-021-12621-6
Miri M, Alahabadi A, Ehrampush MH, Rad A, Lotfi MH, Sheikhha MH, Sakhvidi MJZ (2018) Mortality and morbidity due to exposure to ambient particulate matter. Ecotoxicol Environ Saf 165:307–313. https://doi.org/10.1016/j.ecoenv.2018.09.012
Mokoena KK, Ethan CJ, Yu Y, Shale K, Liu F (2019) Ambient air pollution and respiratory mortality in Xi’an, China: a time-series analysis. Respir Res 20:139. https://doi.org/10.1186/s12931-019-1117-8
Moolgavkar SH, McClellan RO, Dewanji A, Turim J, Luebeck EG, Edwards M (2013) Time-series analyses of air pollution and mortality in the United States: a subsampling approach. Environ Health Perspect 121:73–78. https://doi.org/10.1289/ehp.1104507
Ouyang Y (2013) China wakes up to the crisis of air pollution. Lancet Respir Med 1:12. https://doi.org/10.1016/S2213-2600(12)70065-6
Pelucchi C, Negri E, Gallus S, Boffetta P, Tramacere I, La Vecchia C (2009) Long-term particulate matter exposure and mortality: a review of European epidemiological studies. BMC Public Health 9:453. https://doi.org/10.1186/1471-2458-9-453
Peters A, Döring A, Wichmann HE, Koenig W (1997) Increased plasma viscosity during an air pollution episode: a link to mortality? Lancet. 349:1582–1587. https://doi.org/10.1016/S0140-6736(97)01211-7
Pope CA 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, Thun MJ (2009) Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke. Circulation. 120:941–948. https://doi.org/10.1161/CIRCULATIONAHA.109.857888
Pun VC, Kazemiparkouhi F, Manjourides J, Suh HH (2017) Long-term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults. Am J Epidemiol 186:961–969. https://doi.org/10.1093/aje/kwx166
Qin RX, Xiao C, Zhu Y, Li J, Yang J, Gu S, Xia J, Su B, Liu Q, Woodward A (2017) The interactive effects between high temperature and air pollution on mortality: a time-series analysis in Hefei, China. Sci Total Environ 575:1530–1537. https://doi.org/10.1016/j.scitotenv.2016.10.033
Ren M, Li N, Wang Z, Liu Y, Chen X, Chu Y, Li X, Zhu Z, Tian L, Xiang H (2017) The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses. Sci Rep 7:40482. https://doi.org/10.1038/srep40482
Samoli E, Analitis A, Touloumi G, Schwartz J, Anderson HR, Sunyer J, Bisanti L, Zmirou D, Vonk JM, Pekkanen J, Goodman P, Paldy A, Schindler C, Katsouyanni K (2005) Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project. Environ Health Perspect 113:88–95. https://doi.org/10.1289/ehp.7387
Sun Q, Hong X, Wold LE (2010) Cardiovascular effects of ambient particulate air pollution exposure. Circulation. 121:2755–2765. https://doi.org/10.1161/CIRCULATIONAHA.109.893461
Thabethe NDL, Voyi K, Wichmann J (2021) Association between ambient air pollution and cause-specific mortality in Cape Town, Durban, and Johannesburg, South Africa: any susceptible groups? Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-021-13778-w
Tian YZ, Shi GL, Huang-Fu YQ, Song DL, Liu JY, Zhou LD, Feng YC (2016) Seasonal and regional variations of source contributions for PM10 and PM2.5 in urban environment. Sci Total Environ 557-558:697–704. https://doi.org/10.1016/j.scitotenv.2016.03.107
Tian F, Qi J, Wang L, Yin P, Qian ZM, Ruan Z, Liu J, Liu Y, McMillin SE, Wang C, Lin H, Zhou M (2020) Differentiating the effects of ambient fine and coarse particles on mortality from cardiopulmonary diseases: a nationwide multicity study. Environ Int 145:106096. https://doi.org/10.1016/j.envint.2020.106096
Villeneuve PJ, Goldberg MS, Krewski D, Burnett RT, Chen Y (2002) Fine particulate air pollution and all-cause mortality within the Harvard Six-Cities Study: variations in risk by period of exposure. Ann Epidemiol 12:568–576. https://doi.org/10.1016/S1047-2797(01)00292-7
Wang L, Liu C, Meng X, Niu Y, Lin Z, Liu Y, Liu J, Qi J, You J, Tse LA, Chen J, Zhou M, Chen R, Yin P, Kan H (2018) Associations between short-term exposure to ambient sulfur dioxide and increased cause-specific mortality in 272 Chinese cities. Environ Int 117:33–39. https://doi.org/10.1016/j.envint.2018.04.019
Wang N, Mengersen K, Tong S, Kimlin M, Zhou M, Wang L, Yin P, Xu Z, Cheng J, Zhang Y, Hu W (2019) Short-term association between ambient air pollution and lung cancer mortality. Environ Res 179:108748. https://doi.org/10.1016/j.envres.2019.108748
Wu T, Ma Y, Wu X, Bai M, Peng Y, Cai W, Wang Y, Zhao J, Zhang Z (2019) Association between particulate matter air pollution and cardiovascular disease mortality in Lanzhou, China. Environ Sci Pollut Res Int 26:15262–15272. https://doi.org/10.1007/s11356-019-04742-w
Wu H, You E, Jiang C, Yang Y, Wang L, Niu Q, Lu X, Huang F (2020) Effects of extreme meteorological factors on daily mumps cases in Hefei, China, during 2011-2016. Environ Sci Pollut Res Int 27:4489–4501. https://doi.org/10.1007/s11356-019-07073-y
Xu D, Zhang Y, Sun Q, Wang X, Li T (2021) Long-term PM2.5 exposure and survival among cardiovascular disease patients in Beijing, China. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-021-14043-w
Yan Y, She L, Guo Y, Zhao Y, Zhang P, Xiang B, Zeng J, Yang M, Wang L (2021) Association between ambient air pollution and mortality from chronic obstructive pulmonary disease in Wuhan, China: a population-based time-series study. Environ Sci Pollut Res Int 28:33698–33706. https://doi.org/10.1007/s11356-021-13180-6
Yin P, He G, Fan M, Chiu KY, Fan M, Liu C, Xue A, Liu T, Pan Y, Mu Q, Zhou M (2017) Particulate air pollution and mortality in 38 of China's largest cities: time series analysis. BMJ 356:j667. https://doi.org/10.1136/bmj.j1379
Yu Y, Yao S, Dong H, Wang L, Wang C, Ji X, Ji M, Yao X, Zhang Z (2019) Association between short-term exposure to particulate matter air pollution and cause-specific mortality in Changzhou, China. Environ Res 170:7–15. https://doi.org/10.1016/j.envres.2018.11.041
Zeger SL, Thomas D, Dominici F, Samet JM, Schwartz J, Dockery D, Cohen A (2000) Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect 108:419–426. https://doi.org/10.1289/ehp.00108419
Zhang C, Ding R, Xiao C, Xu Y, Cheng H, Zhu F, Lei R, Di D, Zhao Q, Cao J (2017) Association between air pollution and cardiovascular mortality in Hefei, China: a time-series analysis. Environ Pollut 229:790–797. https://doi.org/10.1016/j.envpol.2017.06.022
Zheng H, Yi W, Ding Z, Xu Z, Ho HC, Cheng J, Hossain MZ, Song J, Fan Y, Ni J, Wang Q, Xu Y, Wei J, Su H (2021) Evaluation of life expectancy loss associated with submicron and fine particulate matter (PM1 and PM2.5) air pollution in Nanjing, China. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-021-15244-z
Zhou M, He G, Fan M, Wang Z, Liu Y, Ma J, Ma Z, Liu J, Liu Y, Wang L, Liu Y (2015) Smog episodes, fine particulate pollution and mortality in China. Environ Res 136:396–404. https://doi.org/10.1016/j.envres.2014.09.038
Zhu F, Ding R, Lei R, Cheng H, Liu J, Shen C, Zhang C, Xu Y, Xiao C, Li X, Zhang J, Cao J (2019) The short-term effects of air pollution on respiratory diseases and lung cancer mortality in Hefei: a time-series analysis. Respir Med 146:57–65. https://doi.org/10.1016/j.rmed.2018.11.019
Acknowledgements
We would like to thank all the subjects who participated in this research. This work was supported by Special Foundation for Science and Technology Development of Central Government Guiding Locals (Contract No. 202007d07050008).
Funding
This work was funded by the Special Foundation for Science and Technology Development of Central Government Guiding Locals (Contract No. 202007d07050008).
Author information
Authors and Affiliations
Contributions
Guoao Li and Fen Huang collaboratively designed the study, both making substantial intellectual contributions. Guoao Li analyzed the data and drafted the manuscript together with Huabing Wu and Qi Zhong, and Fen Huang revised the manuscript. Jialiu He and Wanjun Yang contributed in collecting the data. Jinliang Zhu, Huanhuan Zhao, Hanshuang Zhang, and Zhenyu Zhu all contributed in interpreting the data. Guoao Li and Huabing Wu contributed equally. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The authors declare no competing interests.
Additional information
Responsible Editor: Lotfi Aleya
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Li, G., Wu, H., Zhong, Q. et al. Six air pollutants and cause-specific mortality: a multi-area study in nine counties or districts of Anhui Province, China. Environ Sci Pollut Res 29, 468–482 (2022). https://doi.org/10.1007/s11356-021-15730-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-021-15730-4